Protein Alignment CG34133 and wdr44

DIOPT Version :10

• Sequence 1: NP_001036772.2
• Gene: CG34133 / 318566
• FlyBaseID: FBgn0083969
• Length: 1108
• Species: Drosophila melanogaster
• Sequence 2: XP_002939709.1
• Gene: wdr44 / 100379800
• XenbaseID: XB-GENE-1007867
• Length: 912
• Species: Xenopus tropicalis
• Alignment Length: 1168
• Identity: 448/1168 - (38%)
• Similarity: 581/1168 - (49%)
• Gaps: 335/1168 - (28%)

  Fly     4 LETDSDSSEEFFDAEDTTPNRHSTLCR-KLPPEVAQEFIFPEPAVRVNAAASSDSDATPIGAGTP 67
            :.:||| :||||||    |...:..|. .:.|..::.||..|....     |.:::...|.....
 Frog     1 MASDSD-TEEFFDA----PEDVNLSCSPAVSPTKSETFILKEEVTH-----SRNAETRNIDLKQD 55

  Fly    68 ATRSPTNSLGARLK----PQDAGVFVEPKPVIGPLGRQRFHELRQCMQNDEDDNPGNTLTPDSQN 128
            .::...:|:....:    .::|...||.||.|       .||               |||.::..
 Frog    56 DSKEIIDSIIEESQKYSDTENAHPVVEEKPEI-------LHE---------------TLTAETSK 98

  Fly   129 SS------------TDGIFTNRSTHPFKV-----IETDAMSIQSMTSLGRVGRILAG-SIDPSAI 175
            :|            |:..|.:....|.:.     :|.|....|.           || |.|||.:
 Frog    99 TSQDLLSNIPELVVTESTFHDGVDDPVQQQIGEHVEPDNSRTQK-----------AGPSADPSYV 152

  Fly   176 SIDRESLASLN-----------AQQQKQQAQQQQQAQPTSSTSSNTPPSVGNTSSGMSTPRVSPK 229
            |...|::..|.           .::.:....|::...|:.....:..|::..:......|...|.
 Frog   153 SSAIENIVDLTQDLKIIEDLKIEEEPEISLIQEENKDPSKHIVEDVLPNIPTSDILEQLPPAKPP 217

  Fly   230 HQQSGKEVAATTTGIPSAASSAQSSGVGSMVLQEPDVIASTKLAQSKTTDSITSSGPV------- 287
            .|                            :..|||::||||           ..||.
 Frog   218 RQ----------------------------ICVEPDIVASTK-----------KPGPTRPPLPIN 243

  Fly   288 ------------APPRRKKKSRNCSISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDFVM 340
                        |||.|||||                   |||.|..|     |.:.: :|.|
 Frog   244 VPPPRPPPPARPAPPPRKKKS-------------------DTDFDRSS-----GFEYQ-KDGF-- 281

  Fly   341 EFESSLNNATSSASNITLTCSSTNTVVSASASTSAASSSLPSTIAIHMRPMVASVTIAGPKLTQS 405
                 |.....|                            |:|                  ||::
 Frog   282 -----LGGGLLS----------------------------PNT------------------LTEN 295

  Fly   406 LGSSSTSVHSKPSPSNSAKSNSAPARVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPSQDE 470
            :...     |:||                      |:|..|..|..||..::   |......|..
 Frog   296 MNRD-----SQPS----------------------LDLASATSGEKVVTAQE---NGKAADGQLS 330

  Fly   471 IERIEKMLMESANRPKLAGTGSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTS 535
            .:.||                  |||..                                |.|::
 Frog   331 CQAIE------------------SLGPQ--------------------------------RPRSN 345

  Fly   536 SGKQLTDFEILEQVPVKNLDTGENMPLSEMRSPPVPEGWNPLSLHILKLTSHLEVIQK---ESDE 597
            ||::|||.|||..|.:|||||||.:||| :....:|.|.|||:|||::.|.  |.:..   :||:
 Frog   346 SGRELTDEEILASVMIKNLDTGEEIPLS-LAEEKLPTGINPLTLHIMRRTK--EYVSNDAAQSDD 407

  Fly   598 ESVIGIPPSIEGQQPDEEELETEDGSRLKKKTARIKRFFGSTMR-----------KTVDKAKSIA 651
            |           .:|...:.|| ||.:||:||.::|:|.|.:::           :.|:|.||:.
 Frog   408 E-----------DKPQPHQSET-DGGKLKQKTTQLKKFLGKSVKRAKHLAEEYGERAVNKVKSVR 460

  Fly   652 SEVSHARHKEDVADIVDAMNPEQNIKIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCG 716
            .||.|....:..:...:.|...:.:|.||:...||||:|.:::.|||||||...|||.||||.||
 Frog   461 DEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFEQIKVVQDLSGEHVGAVWTMKFSHCG 525

  Fly   717 RLLATAGQDKVLRIWVLKDAYPFFQDMRNKYNADQKSSPTPSQESLVSQHS-AEEAIAMAT---A 777
            ||||:||||.|:||||||:|:.:|.:||.|||.:.:.||:||||||.|..| .:..:..||   .
 Frog   526 RLLASAGQDNVVRIWVLKNAFDYFNNMRIKYNTEGRVSPSPSQESLNSSKSDTDGGVYSATDDMD 590

  Fly   778 AEKCTGPFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTA 842
            .:....||...|||.|.|||:||||:|||||||:||||||||||||||||:||||||||||||||
 Frog   591 PDDKNAPFRQVPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFVTA 655

  Fly   843 IAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCI 907
            |||||||||||||||||||||||||||||||||||:||||||||||||||||:.||:|:||||||
 Frog   656 IAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEIDGQTKLITAANFCQNGKHAVIGTYDGRCI 720

  Fly   908 FYNTDQLKYHTQIHVRSTRGKNRIGRKISGIEPMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKG 972
            ||:|:.||||||||||||||:||:||||:||||:|||:||||||||||:||||||||:||.||||
 Frog   721 FYDTEHLKYHTQIHVRSTRGRNRVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG 785

  Fly   973 YLNVSSQIKGSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIKAHNATVTCAI 1037
            .:|.|||||.|||||..||::|||::.:|||.|.||.||.:||||||:|||||||||||.||.||
 Frog   786 CVNSSSQIKASFSHDFTYIVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNAVVTSAI 850

  Fly  1038 FAPHPEAIIKPEPDEISNEKLAHNQPDPLVEQHKKGC-----GYVLVSADFNGAIKVFINKTK 1095
            |||:|..::..   |.|:||...:|.:| ||....|.     ..||:||||.|||||||||.|
 Frog   851 FAPNPGLMVSA---ETSSEKQEGDQAEP-VENIPSGALKSDHTEVLLSADFTGAIKVFINKKK 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	12/36 (33%)
		WD40	704..1046	CDD:475233	256/345 (74%)
		WD40 repeat	707..765	CDD:293791	38/57 (67%)
		WD40 repeat	800..834	CDD:293791	30/33 (91%)
		WD40 repeat	841..878	CDD:293791	36/36 (100%)
		WD40 repeat	885..920	CDD:293791	27/34 (79%)
		WD40 repeat	935..975	CDD:293791	32/39 (82%)
		WD40 repeat	978..1003	CDD:293791	15/24 (63%)
		WD40 repeat	1034..1069	CDD:293791	14/34 (41%)
wdr44	XP_002939709.1	Aim21	<22..>236	CDD:371558	48/290 (17%)
		WD40	512..863	CDD:475233	256/353 (73%)
		WD40 repeat	516..556	CDD:293791	27/39 (69%)
		WD40 repeat	613..647	CDD:293791	30/33 (91%)
		WD40 repeat	654..691	CDD:293791	36/36 (100%)
		WD40 repeat	698..733	CDD:293791	27/34 (79%)
		WD40 repeat	748..788	CDD:293791	32/39 (82%)
		WD40 repeat	792..816	CDD:293791	14/23 (61%)