DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCT2 and mkks

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_021336215.1	Gene:	mkks / 393134	ZFINID:	ZDB-GENE-040426-757	Length:	566	Species:	Danio rerio

Alignment Length:	574	Identity:	115/574 - (20%)
Similarity:	225/574 - (39%)	Gaps:	128/574 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DLVKSTLGPKGMDKILVATGRNAGHVEVTNDGATILRAVGVDNPAAKILV-----DMSRVQDEEV 95
            :::.:..||.|  ::........|||..|:....:|:.:.:..|..|::.     ..:|..|..:
Zfish    31 NILSTAYGPTG--RLKQIHNNVGGHVLTTSTSTALLKRLEMSEPLLKLISTALQHHTTRYSDSGL 93

  Fly    96 GDGTTSVTVL---------ASELLREAEKLVEQKLHPQIIVSGWRQATQVALEALTAAAQDNSSS 151
            ..|..::|::         .|..::..:.||||   ..:.:.|.....:|.:|.        ||.
Zfish    94 FMGIFTLTLIENTKKYGLRTSTAIKVYKHLVEQ---CNVYLKGDSCGCKVPVEF--------SSC 147

  Fly   152 DEKFRNDLLNIARTTLSSK----ILHQHKDFFANLAVDAVM-----RLKGSGELKSIQIIKKSGG 207
            |     .|:.:|.:.::||    :..:.....::|...|.:     ...|:........|...|.
Zfish   148 D-----SLVALAHSMITSKPACMLDSRETQQISSLITQAFLYSIPCNSSGTACFGRTVTIGIEGQ 207

  Fly   208 TLGDSFLDEGFLLDKKPGVHQPQRIENARILIANTPMDTDKIKVFGSSIKVDSLAKIADLEM--- 269
            ::..|.:..|.||| .|.:..|..:|.    :.:.|.   |:.:||.|:..| ::::.|:.:
Zfish   208 SVNHSSVFPGLLLD-VPEMLLPGDLER----LGDGPF---KVVLFGVSLSGD-ISEVGDVALEVH 263

  Fly   270 ----AEKEKMKEKV---DKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADFDGIERLAYCT 327
                .|::.:::.:   ::::|.|.::|..:::::...:....:..|:.||......:|..|..|
Zfish   264 RGLNPERDLLQQLLKIGEQVVKDKVSLFACQKVVHPVLQHYLREHEVVVIERLGLALMEPFAKIT 328

  Fly   328 GGEIVSTFENPSLVKLGECDVIEQVMI---GEDTLLRFSGVKLGEACTIVIRGATQQILDE---- 385
            |...|::..  |||.:....::..:..   |...||:....|.....|:|:....:.:|:|
Zfish   329 GARAVASLF--SLVPMEAYGLVAGLCFQDCGSKKLLQLLSSKHAAISTMVLCHRNETMLEELKVC 391

  Fly   386 ---ADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEA-----------IAI 436
               ..|:.|    ||..|::|...:.||||:|..:||.:......|....|           :|:
Zfish   392 AMTCQRAEH----VLRLTLREPYALLGGGCTETQLATHITHMNQSTAPTTAAALGISHSEFLMAV 452

  Fly   437 EAFARALLSLPTAIADNAGYDSAQLVSELRAGH---------AQGKQTLGLDMELGKVADVREL- 491
            |:|..:||    |:|.:..:|....:.:|..||         .:.|.|.|    .|.:.|...|
Zfish   453 ESFRSSLL----AVALSLEHDGQDCLIDLTYGHRWVMDISSQTEVKHTCG----CGLLEDRSNLE 509

  Fly   492 -----------------------GITESFAVKRQVLMSASEAAEMILRVDNIIR 522
                                   .:.:||:.|...|..|.|.|.::|.|..||:
Zfish   510 KTHLNTACQTFSPVFLENNDTQPKVLDSFSAKLNALNVAVEMASLVLDVKYIIK 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	115/574 (20%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	115/574 (20%)
mkks	XP_021336215.1	Cpn60_TCP1	29..565	CDD:306598	115/574 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810