DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT2 and Cct7

DIOPT Version :9

Sequence 1:	NP_572524.1	Gene:	CCT2 / 31838	FlyBaseID:	FBgn0030086	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001100073.1	Gene:	Cct7 / 297406	RGDID:	1306422	Length:	544	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	195/539 - (36%)
Similarity:	301/539 - (55%)	Gaps:	24/539 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MSLNPVRVLKNEAQEEKAEMARLSSFIGAI-AIGDLVKSTLGPKGMDKILVATGRNAGHVEVTND 66
            |...||.:|| |..:....:.:|.|.|.|. .|.:.|::||||:||||::| .||  |...::||
  Rat     1 MMPTPVILLK-EGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIV-DGR--GKATISND 61

  Fly    67 GATILRAVGVDNPAAKILVDMSRVQDEEVGDGTTSVTVLASELLREAEKLVEQKLHPQIIVSGWR 131
            |||||:.:.|.:||||.|||:::.||.||||||||||:||:|.|::.:..||:.||||||:..:|
  Rat    62 GATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFR 126

  Fly   132 QATQVALE-----ALTAAAQDNSSSDEKFRNDLLNIARTTLSSKILHQHKDFFANLAVDAVMRLK 191
            .|||:|:.     |:|...||....    |..|...|.|.||||::.|.|.|||.:.|||||.|.
  Rat   127 TATQLAVNKIKEIAVTVKKQDKVEQ----RKMLEKCAMTALSSKLISQQKVFFAKMVVDAVMMLD 187

  Fly   192 GSGELKSIQIIKKSGGTLGDSFLDEGFLLDKK---PGVH-QPQRIENARILIANTPMDTDKIKVF 252
            ...:||.|.|.|..||.|.:|.|..|....|.   .|.. ||::.:|.:|.:.|..::. |.:..
  Rat   188 ELLQLKMIGIKKVQGGALEESRLVAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELEL-KAEKD 251

  Fly   253 GSSIKVDSLAKIADLEMAEKEKMKEKVDKILKHKCNVFINRQLIYNYPEQLFADARVMSIEHADF 317
            .:.|:|.::.....:..||...:.:|::||.:....|.:::..|.:...|.|||..:........
  Rat   252 NAEIRVHTVEDYQAIVDAEWNILYDKLEKIHQSGAKVILSKLPIGDVATQYFADRDMFCAGRVPE 316

  Fly   318 DGIERLAYCTGGEIVSTFENPSLVK--LGECDVIEQVMIGEDTLLRFSGVKLGEACTIVIRGATQ 380
            :.::|.....||.|.::..  :|:.  ||.|.|.|:..||.:....|:|....:.|||::||..:
  Rat   317 EDLKRTMMACGGSIQTSVN--ALIPDVLGRCQVFEETQIGGERYNFFTGCPKAKTCTIILRGGAE 379

  Fly   381 QILDEADRSLHDALCVLAATVKESRIIFGGGCSEALMATAVLKKAAETPGKEAIAIEAFARALLS 445
            |.::|.:||||||:.::...:|...::.|||..|..::..:...:...|||:.:.|.|:|:||..
  Rat   380 QFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEI 444

  Fly   446 LPTAIADNAGYDSAQLVSELRAGHAQGKQTLGLDMELGKVADVRELGITESFAVKRQVLMSASEA 510
            :|..:.||||:|:..::::|||.||||....|:|:....:||..:..:.|...|:...|.:||||
  Rat   445 IPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINNEDIADNFQAFVWEPAMVRINALTAASEA 509

  Fly   511 AEMILRVDNIIRCAPRRRV 529
            |.:|:.||..|: .||..|
  Rat   510 ACLIVSVDETIK-NPRSTV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT2	NP_572524.1	PTZ00212	1..530	CDD:185514	195/539 (36%)
CCT2	NP_572524.1	TCP1_beta	10..527	CDD:239452	190/528 (36%)
Cct7	NP_001100073.1	TCP1_eta	5..525	CDD:239456	192/531 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60896
OrthoDB	1	1.010	-	-		D205390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830