DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15365 and lzts2

DIOPT Version :9

Sequence 1:	NP_001285030.1	Gene:	CG15365 / 31829	FlyBaseID:	FBgn0030077	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001006721.1	Gene:	lzts2 / 448373	XenbaseID:	XB-GENE-1216151	Length:	683	Species:	Xenopus tropicalis

Alignment Length:	745	Identity:	164/745 - (22%)
Similarity:	277/745 - (37%)	Gaps:	268/745 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 AAEEEAMQSLPATLP---------------QQHQQQQQRRTTPIAGGSRHQQQQQMGEAEQTSGN 207
            ::::.....||...|               :..:::......||:..|   ..:.:.|....:||
Frog    83 SSQDPLFNGLPTKKPSTTTSGNNGNYVYVNEDFKEEWHEPRVPISPSS---DAEDIREERALNGN 144

  Fly   208 ----------------------FLRPIAFKPIPFEPDYRIACQQQQQHQQQLQLQQQQQQQQQQQ 250
                                  .::|.||||:           ..::....||...|:.......
Frog   145 IRGPPPKLIPVSGKLEKNVEKTLIKPTAFKPV-----------VPKKRNSSLQYLVQRNGGPGLS 198

  Fly   251 QQQQLQLQHQQQQQHQQQHQHQHQQQHQSLQLPTEGGQAG----------------GVAAERYGY 299
            :.|                        .||.|...|..||                |..::.
Frog   199 ESQ------------------------SSLNLLFNGNAAGIPEKHNLLSCRNSTHSGTMSDS--- 236

  Fly   300 GSTPSLAPLPTASAQKFGSTTDLRHLAARRRNHRLLQRCSNE-DALTLDL--LSTGSH------- 354
            |.| ||:.|||.|.                       .||:: |.:::.:  ::..:|
Frog   237 GRT-SLSSLPTYST-----------------------NCSHQMDPVSVSMGHINLDNHTNINGYS 277

  Fly   355 DR-PDG------------ASSKSSGTVVGSSDLTPSPSDSG-------------ISELEAALKDR 393
            || |.|            :||||:|::.|..:  || ||||             |.|||..||||
Frog   278 DRAPRGRTRPTNSDSGRSSSSKSTGSLSGRGN--PS-SDSGSCDRSPILSDEILIRELEEKLKDR 339

  Fly   394 DSELSYLRQAMEHNEKVIFQVQKDKEVYWEHETQRLRLFYEGQQRECQLKLRKMEQLLGLQQFQL 458
            :.||..|::.::.||..|.||.::|:...|.|.:.||.....:.::...|.::::|:|.||.|||
Frog   340 EMELQQLKENLDENEAAICQVYEEKQKRCEQEMEELRQSCALKMKQAAQKAQRLQQVLQLQIFQL 404

  Fly   459 KQHKLRQSEQVNRLQQQLDLARDSSQGLQQQVDALRHQLEDSEWRVCERNGEIALLKTQLKEAHL 523
            :|.|.:..|..::|.|:.:|........:::......:||:::|.||:::|||:|||.|||::..
Frog   405 QQEKKKLQEDFSQLLQERELLEKRCASFEREQTEFGPRLEETKWEVCQKSGEISLLKQQLKDSQA 469

  Fly   524 EINMKDHAIVSLKHSSNRSSSSSNSNSNKSCDTNTSQSQPKQQAKEEQQQQQHPELQQQQQQQQQ 588
            |:..|.:.|:.|:                                 .|.::...:||..::|.|:
Frog   470 ELAQKSNEILLLR---------------------------------AQVREARSDLQISEEQVQE 501

  Fly   589 QQQQQQQQQQQQQQQQQQQQQQQQQQQQLKQQHQPDQQQLQKIITLKDQVIGALTSELAKLRKEL 653
            .|.....:..:.:..:.:.|:::.:.:.|:          :|...|..:|.|...:.:|.||
Frog   502 LQDTAHTKTLELEVCENELQRKKNEAELLR----------EKASKLDQEVAGLREAAVANLR--- 553

  Fly   654 SDLAIAHEYGEEPCGRYTRLKQQLDNLNEICQKTRKYTTTSASPTAVASPAAQVAPPAPSPAAHV 718
            ..|.:.|| .|:|...|                        .|..|.|
Frog   554 HGLCLCHE-KEDPFLLY------------------------ESDEAKA----------------- 576

  Fly   719 ATPSCAQELPKLDVLVQRLQLDQGQGTQQTLDTLIEESTTYAEDIAKLRQKLDDFRLNLELEKRQ 783
                            ||...|..||.||.::.|.|..|:   :..:.:::.|.|    |.|:|.
Frog   577 ----------------QRQNADNLQGLQQYVERLREALTS---ERRRYQEQADSF----EDERRI 618

  Fly   784 WSAEKDKVLGYQKQLQAHYIQMYQKLRCLD 813
            |..||:||:.||||||.:||||||:.|.|:
Frog   619 WQEEKEKVIRYQKQLQHNYIQMYQQNRELE 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Syntaphilin	<486..>518	CDD:291936	11/31 (35%)
lzts2	NP_001006721.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..107		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..320		17/60 (28%)
		Smc	<323..>537	CDD:224117	62/256 (24%)
		Fez1	446..652	CDD:399656	74/314 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4689
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19354
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5825
SonicParanoid	1	1.000	-	-		X1017
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.090