Protein Alignment CG15365 and Lzts2

DIOPT Version :10

• Sequence 1: NP_001285030.1
• Gene: CG15365 / 31829
• FlyBaseID: FBgn0030077
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_663478.2
• Gene: Lzts2 / 226154
• MGIID: 2385095
• Length: 671
• Species: Mus musculus
• Alignment Length: 698
• Identity: 146/698 - (20%)
• Similarity: 252/698 - (36%)
• Gaps: 229/698 - (32%)

  Fly   172 PQQHQQQQQR------RTTPIAGGSRHQQQQQMGEAEQTSGNFLRPIAFKPI-------PFEPDY 223
            |::||.....      :..|::|......::.:          :||.||||:       |..|.:
Mouse   110 PREHQAHNAHLRGPPPKLIPVSGKLEKNMEKIL----------IRPTAFKPVLPKPRGAPSLPGF 164

  Fly   224 ---RIA-CQQQQQHQQQL---QLQQQQQQQQQQQQQQQLQLQHQQQQQHQQQHQHQHQQQHQSLQ 281
               |.| ....|....||   ...............:.|.|
Mouse   165 LGPRAAGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAL------------------------ 205

  Fly   282 LPTEGGQAGGVAAERYGYGSTPSLAPLPTASAQKFGSTTDL--RHLAARRRNHRLLQRCSNEDAL 344
                .|.|.|..:.........||:.|||.|......||:.  .||.:.......|...:..
Mouse   206 ----SGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTNSPGGHLPSHGPGRGALPGPARG--- 263

  Fly   345 TLDLLSTG-SH-DRPDGASSKSSGTV----------------VGSSD---------LTPSPSDSG 382
                :.|| || |....:||||:|::                .|||.         ..|.|||..
Mouse   264 ----VPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGARASPGSSSGGDRSPPPPPPPPPSDEA 324

  Fly   383 ISE--LEAALKDRDSELSYLRQAMEHNEKVIFQVQKDKEVYWEHETQRLRLFYEG-----QQREC 440
            :..  ||..|:||::||..||.:|:.:|..:.|....::..|..|        .|     |.::.
Mouse   325 LLHCVLEGKLRDREAELQQLRDSMDESEATVCQAFGARQRRWPRE--------RGEDCAAQAQQA 381

  Fly   441 QLKLRKMEQLLGLQQFQLKQHKLRQSEQVNRLQQQLDLARDSSQGLQQQVDALRHQLEDSEWRVC 505
            ..::::.:|||.||.|||:|.|.:..:...:|.|:.:.........:::...|..:||:::|.||
Mouse   382 TQRVQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATFEREQRELGPRLEETKWEVC 446

  Fly   506 ERNGEIALLKTQLKEAHLEINMKDHAIVSLKHSSNRSSSSSNSNSNKSCDTNTSQSQPKQQAKEE 570
            :::|||:|||.||||:..|:..|...:|:|:.:...:.::
Mouse   447 QKSGEISLLKQQLKESQAELVQKGSELVALRVALREARAT------------------------- 486

  Fly   571 QQQQQHPELQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLKQQHQPDQQQLQKIITLK 635
                    |:..:.:.:..|:..:.::|:.:...|:.|:.:|:.::|:::
Mouse   487 --------LRVSEGRARGLQEAARAREQELEACSQELQRYRQEAERLREK--------------- 528

  Fly   636 DQVIGALTSELAKLRKELSDLAIAHEYGEEPCGRYTRLKQQLDNLNEICQKTRKYTTTSASPTAV 700
               .|.|.:|.:.||.
Mouse   529 ---AGHLDAEASGLRD------------------------------------------------- 541

  Fly   701 ASPAAQVAPPAPSPAAHVATPSCAQELPKLDVLVQRLQLDQGQGTQQTLDTLIEESTTYAEDIAK 765
                    ||.| ||  ...|....|..  :..|||.....|...:..::.|.:|       :.:
Mouse   542 --------PPVP-PA--TTDPFLLAESD--EAKVQRAAAGAGGSLRAQVERLRQE-------LQR 586

  Fly   766 LRQKLDDFRLNLELEKRQWSAEKDKVLGYQKQLQAHYIQMYQKLRCLD 813
            .:::.|:.|.:.|.|:..|.|||::|:.||||||.:|||||::.|.|:
Mouse   587 EQRRGDEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLE 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15365	NP_001285030.1	Fez1	<735..812	CDD:462015	26/76 (34%)
Lzts2	NP_663478.2	Required for centrosomal localization. /evidence=ECO:0000250	1..333		53/267 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..324		42/209 (20%)
		GAS	<404..473	CDD:464001	20/68 (29%)
		Fez1	441..638	CDD:462015	64/314 (20%)
		Sufficient for interaction with CTNNB1. /evidence=ECO:0000250	449..671		61/306 (20%)
		Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severing. /evidence=ECO:0000250	452..671		59/303 (19%)
		Nuclear export signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03026	633..642		1/2 (50%)