DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32751 and vanin-like

DIOPT Version :9

Sequence 1:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_572297.1	Gene:	vanin-like / 31551	FlyBaseID:	FBgn0040069	Length:	558	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	392/539 - (72%)
Similarity:	455/539 - (84%)	Gaps:	25/539 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKNYWGFFLFCLALGLMLNLSQQASLFKRDFYTAGVVEFEPS----NELSDNLAGYLEIIQSQN 61
            |:..:|...:..|.||||..:||||:|.:.|:||||||||:.|    :..||:||||:|||.|:|
  Fly     1 MSNTWWWLSVVLLILGLMPGMSQQAALAESDYYTAGVVEFKQSILSLSAWSDSLAGYVEIINSEN 65

  Fly    62 ATSTDIIVFPESTLNSAGSTTFVPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYIVINLT 126
            |::||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly    66 ASATDIIVFPESTLNSAGSTTFVPNPEDQINPCLSDPNATYYEEFLVTLSCAARNASKYIVINLT 130

  Fly   127 EKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLYGEPKNSTFLPELSTFETDFG 191
            |||||||||||||||||||||||||||||||||||||||||||||||.|||||||||.|||||||
  Fly   131 EKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRYRKVHLYGEAKNSTFLPELITFETDFG 195

  Fly   192 VTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLTVNGIFSSKAVQIQLGWSYANNV 256
            |||||||||||||||||||||||||||||||||||||||||||        |||.|.||:|||:|
  Fly   196 VTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFLT--------AVQTQQGWAYANDV 252

  Fly   257 NLLAAGASDPIVGNSGSGIYHGRSGSLRSVMRQESGERSIYVARVPKY--------RAKRRMKRD 313
            ||||:|||.|.:|||||||||||||:|.|||||:||||:||||:||||        ||||.::..
  Fly   253 NLLASGASRPSIGNSGSGIYHGRSGTLTSVMRQDSGERAIYVAQVPKYTRSRSLKKRAKRSLQEI 317

  Fly   314 LKRQVATSSSFNIKRDYLENFTSEELKIDAGKIGNLSQNLCHGGFCCHFDLAWRSLGKPSRNTSH 378
            ..||||:||||.:||||:||:.||.||:|.|..|.:::.:|.|.|||:||:||||||..:.|.|:
  Fly   318 QTRQVASSSSFYMKRDYVENYESELLKLDEGTSGAINRTICQGSFCCNFDIAWRSLGTATENGSY 382

  Fly   379 YSYRVGIYEGWRNEKRLDVNYIRNCGVFTCSGNSIDDCGQLLP---DIQRPLVTFTHVEIRVTYP 440
            ||||:|.|:|||||..:|.||||||.:|||||:||||||:|||   ::|:..||||.:.|.||||
  Fly   383 YSYRLGTYDGWRNENNVDANYIRNCALFTCSGDSIDDCGKLLPTEGELQQSRVTFTRLAIGVTYP 447

  Fly   441 QSREFLLFPDTLLDNLLPLEPKQFEWSQKRISEESH--QVRFALRKSLEVKHLLTFGIYGNYYNN 503
            :|||||||||||.|:||||||.||||||::.:|:|:  :|||||:::.|:.:|||||||||||:|
  Fly   448 ESREFLLFPDTLQDSLLPLEPSQFEWSQRKPTEDSYVQEVRFALKETQELSNLLTFGIYGNYYDN 512

  Fly   504 ECTFGVGTAEEQLECGYKN 522
            ||||||||.||||.|||::
  Fly   513 ECTFGVGTEEEQLACGYRS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	251/307 (82%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	114/183 (62%)
vanin-like	NP_572297.1	biotinidase_like	33..304	CDD:143591	238/278 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466612
Domainoid	1	1.000	107	1.000	Domainoid score	I6443
eggNOG	1	0.900	-	-		E1_COG0388
Homologene	1	1.000	-	-		H37255
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4181
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		otm26620
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	1	1.100	-	-	P	PTHR10609
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
	12	11.800