DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32751 and Vnn3

DIOPT Version :9

Sequence 1:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_036109.3	Gene:	Vnn3 / 26464	MGIID:	1347055	Length:	500	Species:	Mus musculus

Alignment Length:	556	Identity:	145/556 - (26%)
Similarity:	218/556 - (39%)	Gaps:	133/556 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 W--GFFLFCLALGLMLNLSQQASLFKRDFYTAGVVEFE---PS---------------NELSDNL 50
            |  .|..|..|:|.|            |.:.|.|.|..   |:               |:..|.|
Mouse     9 WAVSFVFFAQAVGSM------------DTFIAAVYEHAVILPNKTESPVSTEEALLLINKNIDIL 61

  Fly    51 AGYLEIIQSQNATSTDIIVFPESTLNS---AGSTTF-----VPNPEDQINPCLSDPNATYYEEFL 107
            ...:::...|.|   .|||.||..:..   ...|.:     :|:||....|| .||....|....
Mouse    62 ESAIKLAARQGA---HIIVTPEDGIYGWIFTRETIYPYLEDIPDPEVNWIPC-RDPRRFGYTPVQ 122

  Fly   108 VTLSCAARNASKYIVINLTEKQKCEDIPEDTRP-CASNGLNVFNTNVVFDRQGVVVSRYRKVHLY 171
            ..|||.|:..|.||:.|:.:|:.|    ..|.| |..:|...:|||||||.:|.:.:||.|.:|:
Mouse   123 ERLSCLAKENSIYIMANIGDKKPC----NATDPHCPPDGRYQYNTNVVFDSKGRLTARYHKYNLF 183

  Fly   172 GEPKNSTFLP---ELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQLPFL 233
             ||:.....|   ||.||:|.|| .||.|.||||..|.||..::.:..:...:.|..|::.||.|
Mouse   184 -EPEIQFDFPKDSELVTFDTPFG-KFGIFTCFDIFSYDPAVVVVKDTQVDSVLLPTAWYNTLPLL 246

  Fly   234 TVNGIFSSKAVQIQLGWSYANNVNLLAAGASDPIVGNSGSGIYHGRSGSLRSV------MRQESG 292
            :        ||.....|:.|..||:|||...:..:..:|||||     |..:|      |..|||
Mouse   247 S--------AVPFHSVWARAMGVNVLAANTHNTSMHMTGSGIY-----SPEAVRVYHYDMETESG 298

  Fly   293 ERSIYVARVPKYRAKRRMKRDLKRQVATSSSFN-------IK-----------RDYLENFTSEEL 339
            :  :.::.:          |...||.||.:..|       :|           :.|.:.|:..:|
Mouse   299 Q--LLLSEL----------RSRPRQHATPAEVNWSAYARTVKPFSSGQADFPGKIYFDEFSFTKL 351

  Fly   340 KIDAGKIGNLSQNLCHGGFCCHFDLAWRSLGKPSRNTSHYSYRVGIYEGWRNEKRLDVNYIRNCG 404
               .|..||.:  :|....|||...      |.|.:.....|.:|.::|....:  ...|::.|.
Mouse   352 ---TGSAGNYT--VCQKDLCCHLTY------KMSESRMDEVYVLGAFDGLHTVE--GQYYLQICT 403

  Fly   405 VFTCSGNSIDDCGQLLPDIQRPLVTFTHVEIRVTYPQSREFLLFPDTLLD-NLLPLEPKQFEWSQ 468
            :..|...:...||:   .:......|....:..|:   |...:||..:|. :.|.||
Mouse   404 LLKCQTTNSRTCGE---PVGSAFTKFEEFSLSGTF---RTKYVFPQIVLSGSQLALE-------- 454

  Fly   469 KRISEESHQVRFALRKSLEVKHLLTFGIYGNYYNNE 504
             |..|.|...|...|....:. :|...:||..:..:
Mouse   455 -RYYEVSRDGRLRSRGGAPLP-ILVMALYGRVFERD 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	101/349 (29%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	39/197 (20%)
Vnn3	NP_036109.3	biotinidase_like	26..329	CDD:143591	100/337 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847837
Domainoid	1	1.000	96	1.000	Domainoid score	I7293
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I4179
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8847
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.660