DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Moe and Inava

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_006249982.1	Gene:	Inava / 289399	RGDID:	1311892	Length:	678	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	66/333 - (19%)
Similarity:	127/333 - (38%)	Gaps:	66/333 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 WEQSIMT------WWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNK-KGTDLWLGVDA--- 294
            ||.|.:.      |.:...|.|...:..:.:..::|         |:.:. .|..|..|.|:
  Rat    70 WENSRLPTHPGPGWDRRSPSFLAAPSSQKLIMESKD---------EVSDSDSGIILQSGPDSPVS 125

  Fly   295 ----LGLNIYEQDDRLTPKIGFPWSEIRNISFSE--------KKFIIKPIDKKAPDFMFFAPRVR 347
                |...:.:|...|..::.....|:|.:...|        .::.:||.:|        ||:||
  Rat   126 PMKELTNAVRKQQRALEARLEACLEELRRLCLREAELTGTLPAEYPLKPGEK--------APKVR 182

  Fly   348 INKRILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLALAARERAEKKQQEY 412
               |.:.......|..:.|..|.:...:|:..|.:..:.|::...|:.....|.|:|.....||
  Rat   183 ---RRIGAAYKLDEWALHREDPLSSLERQLALQLQITEAARRLCAEENLSRQARRQRKHAALQE- 243

  Fly   413 EDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQL--QAAKDELELRQKELQAMLQRLEE----- 470
            |.:|:.:|..:...:|:.......:..|..:|...  .:..|.|.|.:::.||.....|.
  Rat   244 EKKLRDLQRCLGDRRRNSEPPPSTVPSLGRELSASDDSSLSDGLLLEEEDSQAPKPPPESPAPPS 308

  Fly   471 ----AKNMEAVEKLKLEEEIMAKQMEVQRIQDEVNAKDEETKRLQDEVEDARRKQVIAAEAAAAL 531
                .:::|.::....|    :..:|...||   |:..:||. |....|..|:...:::|::
  Rat   309 RPLPPQSLEGLQPTGPE----SGGLERAPIQ---NSPWKETS-LDHPYEKPRKSSELSSESS--- 362

  Fly   532 LAASTTPQ 539
             :.:||||
  Rat   363 -SPATTPQ 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	7/43 (16%)
		FERM_N	28..83	CDD:286467
		FERM_M	163..278	CDD:278785	7/43 (16%)
		FERM_C_ERM	272..368	CDD:270015	21/111 (19%)
		GBP_C	<375..497	CDD:303769	24/132 (18%)
		ERM	403..649	CDD:279153	31/148 (21%)
		coiled coil	464..477	CDD:293879	2/21 (10%)
		coiled coil	486..497	CDD:293879	1/10 (10%)
Inava	XP_006249982.1	DUF3338	108..231	CDD:288652	25/133 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900