DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Moe and frmd4b

DIOPT Version :9

Sequence 1:	NP_727290.1	Gene:	Moe / 31816	FlyBaseID:	FBgn0011661	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_002940561.2	Gene:	frmd4b / 100489171	XenbaseID:	XB-GENE-958639	Length:	1024	Species:	Xenopus tropicalis

Alignment Length:	669	Identity:	140/669 - (20%)
Similarity:	262/669 - (39%)	Gaps:	160/669 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DAELEFAIQSTTTGKQLFDQVVKTIGLREVWFFGLQYTDSKGDSTWIKLYKKPESPAIKTIKYLK 96
            |.|||..:|.....::|.|.|.....|:|..:||:.:.|..|...|::|
Frog    68 DRELELLVQPKLLSRELLDLVASHFSLKEKEYFGISFLDDTGQYAWLQL---------------- 116

  Fly    97 RVKKYVDKKTADSNGVNHLETSEEDDDADDMTGSMPFSTWVMNQDVKKENPLQFRFRAKFYPEDV 161
                  |::..|.:                    .|          ||..|:...|..:||.|.:
Frog   117 ------DQRVLDHD--------------------FP----------KKSGPVSLYFVVRFYIESI 145

  Fly   162 AEELIQDI-TLRLFYLQVKNAILTDEIYCPPETSVLLASYAVQARHGDHNKTTHTAGFLANDRLL 225
            .  .::|| |:.||:|..|..:....|....||...||:..:|...||::...:....|.....|
Frog   146 T--FLKDITTVELFFLNAKACVFKGLIEVDSETIFKLAALILQEARGDYSSDENARKDLKILPAL 208

  Fly   226 PQRVIDQHKMSKDEWEQSIMTWWQEHRSMLREDAMMEYLKIAQDLEMYGVNYFEIRNKKGTDLWL 290
            |.|.:.:|. |....|..::...::.:.:.|..|::.|:||.:.|..|||:|:::::|:|...||
Frog   209 PTRALQEHP-SLSYCEDRVIEHCKKLKGVTRGQAIVRYMKIVEALPTYGVHYYKVKDKQGIPWWL 272

  Fly   291 GVDALGLNIYEQDDRLTPKIGFPWSEIRNISFSEKKFIIKPIDKKAPDFMFFAPRVRINKR---- 351
            |:...|:..|:..|::.|:..|.|.::.|:.|.||||.::..|.:         |:.:::|
Frog   273 GISFKGIGQYDIQDKIKPRKLFQWKQLENLYFREKKFAVEVHDPR---------RISVSRRTFGQ 328

  Fly   352 -----------------ILALCMGNHELYMRRRKPDTIDVQQMKAQAREEKNAKQQEREKLQLAL 399
                             |..:.:..|:.|:.|:        |.||:.   .:||..:...::|..
Frog   329 SSLVVQTWYASNSLIKSIWVMAISQHQFYLDRK--------QSKAKI---PSAKSLDDIAMELTE 382

  Fly   400 AARERAEKKQQ--------EYEDRLKQMQEDMERSQRDLLEAQDMIRRLEEQLKQLQAAK-DELE 455
            |...:..:..:        .....:....:|.|.|:...:|....:::.||.|:.:...| :||:
Frog   383 AGTTKVARIVEGKNPLIMASSGSLISSGSQDSEISEEQRMEKIQELKKKEEALQNILLKKIEELK 447

  Fly   456 ---LRQKELQAMLQRL------EEAKN----MEAVEKL-------------KLEEEIMAKQMEVQ 494
               ||:.||...|...      |:..|    |.|..||             :||.:.:.:|..|:
Frog   448 KICLREAELTGKLPTEYPLNPGEKPPNVRRRMGATFKLNDILHTDEDPALQELERKFLIQQQLVE 512

  Fly   495 ---RIQDEVN-AKDEETKRLQDEVEDARRKQVIAAEAAAALLAASTTP--QHHHVAEDENENEEE 553
               ::..|.: :|:.:.||.||..:..::.|.:.:......:.:..||  :...:.:|:....|.
Frog   513 ATKKLATEPDLSKNVKRKRKQDYSDSIKKLQELESTINEFRVKSGKTPTKRASMILQDDIIPSET 577

  Fly   554 LTNGDAGGDVSRDLDTDEHIKDPIEDRRTLAERNERLHDQ-----LKALKQD--LAQSRDETKET 611
            .:..|.               ..:||..:...:.:|||:.     .|::..|  ||:.....::.
Frog   578 SSLSDT---------------TTLEDDESQLPQGQRLHNSPNVHLTKSIGGDKSLARKFSLNEQL 627

  Fly   612 ANDKIHRENVRQGRDKYKT 630
            :..::.||........|||
Frog   628 SEMRVTREPSSTHSSPYKT 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Moe	NP_727290.1	B41	26..278	CDD:214604	57/246 (23%)
		FERM_N	28..83	CDD:286467	16/50 (32%)
		FERM_M	163..278	CDD:278785	31/115 (27%)
		FERM_C_ERM	272..368	CDD:270015	28/116 (24%)
		GBP_C	<375..497	CDD:303769	32/159 (20%)
		ERM	403..649	CDD:279153	51/276 (18%)
		coiled coil	464..477	CDD:293879	4/22 (18%)
		coiled coil	486..497	CDD:293879	2/13 (15%)
frmd4b	XP_002940561.2	Ubiquitin_like_fold	57..145	CDD:391949	26/128 (20%)
		B41	60..260	CDD:214604	57/246 (23%)
		FERM_C_FRMD4A_FRMD4B	256..366	CDD:270012	29/126 (23%)
		DUF3338	393..525	CDD:371743	26/131 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910