Protein Alignment drd and nrf-6

DIOPT Version :10

• Sequence 1: NP_001033845.1
• Gene: drd / 318102
• FlyBaseID: FBgn0260006
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_495680.1
• Gene: nrf-6 / 174287
• WormBaseID: WBGene00003813
• Length: 822
• Species: Caenorhabditis elegans
• Alignment Length: 720
• Identity: 168/720 - (23%)
• Similarity: 290/720 - (40%)
• Gaps: 141/720 - (19%)

  Fly   171 WALKMHDSSGKLNSGILNGNINQPGDFDQCLGIQQRMNQDQDAGQDQDGDSIIRGQYCL----AY 231
            |...:.|:.||:.:||::||....|.:..|..|        |..::..|.. .:|||||    ||
 Worm   153 WIFNVFDAMGKVPAGIMSGNNLWVGSWSTCRKI--------DVVKNAQGQK-WKGQYCLATIDAY 208

  Fly   232 AQ--PVLPHNSKRLKSFFKLIQSHGPFK-------SEFNDPGHRVPRYSLINWGLCVPSGCSARD 287
            .:  |::         :|..:.|..|.|       ....|.|.....:.::.:|:|:|:.|:..|
 Worm   209 ERDNPLV---------YFGNMMSGPPDKHCYDKTVKNVTDDGFCFALFPVLKFGVCMPNTCTNHD 264

  Fly   288 VE--YSVAEYLGNQTASTGITFNVRVEPQMCQVRD-QRPWDRNTTWAVRFFLLVLSVAVLS--TI 347
            |:  .|.|.........|....||.||   |:... ......|.......:||:.:|.:::  |:
 Worm   265 VKQMLSFAIRATEGAVGTKSVCNVDVE---CRAESYSDAMSENGLAMFALYLLIATVVLVTFGTL 326

  Fly   348 YDRSTKSQPKQN------------PWFTAFSLDKNLRWLFSTSSAPGDIEAVHGIRFLNAIMLIF 400
            ||....|:..|:            .:..|||:..|...:..:.....:|.::||:|||:...:|.
 Worm   327 YDLFIVSKAPQDEKNSSAFNHPFIKFILAFSMYTNGSEILQSKKNDREINSLHGVRFLSMCWIIL 391

  Fly   401 SHKSMAMFFNPYNNRTAMSESL--------GQPWTVIGRAASLYTDPFLLFSGMLTSYSLFGRLM 457
            .|...      |...:..:::|        .|..|.|...|.|..|.|...||||.::|.|.:.|
 Worm   392 GHTYY------YIGTSLTTDNLVPTLINFPKQFHTQIIVQAPLAVDSFFFLSGMLAAFSFFKKTM 450

  Fly   458 KQQPIRLKNE---------------YISRLMRIVPPLAALILFCTYVLPLWGSGPQWNLVVGHHA 507
            |..|    |.               |..|.:||.|....::||...:.....:||.|..:   ..
 Worm   451 KADP----NHPPKLSAFNWQTWPMYYYKRYIRITPTYIIVMLFDVTLFTYISNGPFWRPI---ER 508

  Fly   508 DICKKNWWRNLLFIHNY-FGFSEMCLTHTHHLGIDTEL-FAVAPLLILALWRWPRR-------GL 563
            ..|...||.||::::|: ....|.|:..|.:|..|.:. ..:.|||::...:|..:       ||
 Worm   509 QGCSIAWWTNLIYLNNFLLQDQECCMGWTWYLANDMQFHIFLMPLLVIVFLKWGMKVGLGLSTGL 573

  Fly   564 FALLLLCTVGTAARYYTTIVNQLSNY---IYFGTNIQRLFRTADY---MYSFPPHRSTVYIMGIL 622
            .||..|..:         |:.|:..|   ......:|.:::..||   :|..|..|.|.:|:||:
 Worm   574 IALSSLIRL---------IITQIYGYPPAPILTAKLQIVYQLNDYWNDVYVRPYIRCTPFIVGIV 629

  Fly   623 LGYVLRKYQNARLSSLQLRLG-------WLVATVCVLASLLGP---APMGDINYVYNSTHAAIYA 677
            :.|:|..:.......|:::|.       |..:||..|.|:.|.   |..|||:..:.    .:|.
 Worm   630 VAYLLNAWTTREQKDLKIKLERRTVIICWCTSTVLGLYSVFGLYWFAKTGDISKPWE----ILYT 690

  Fly   678 AFAPIAWCLFFSWIVFVSHNGYTNKLTKLFAWRGFQVSTKLSYAIYLTQFPVF--FFNVGRRRHI 740
            .|...|:.|...|:||....|....:..:.:||.|...:|:::..||.. |:.  .:|:.|.:..
 Worm   691 IFGTPAYALALGWVVFACTTGNGGPVDTILSWRLFVPLSKITFCAYLLH-PIMLQIYNLSRPQPF 754

  Fly   741 HHYYNFVSIILDTNEFI-SIFLASVALTVLFDAPFQNLKKLLIKRPTAAKVVKDSKAKAAESQDA 804
             |:..|:.:|..|.|.: :.:..:...::.|:.|...:.::|.          :|| |....::.
 Worm   755 -HFTTFIQMIRYTVEAVFASYTIAFFFSLAFEKPLNKIDEMLF----------NSK-KMMNGENG 807

  Fly   805 TTTTL 809
            .||.:
 Worm   808 NTTEM 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drd	NP_001033845.1	NRF	154..292	CDD:466307	33/135 (24%)
		OafA	377..788	CDD:441440	109/461 (24%)
nrf-6	NP_495680.1	NRF	151..288	CDD:214781	36/152 (24%)
		OafA	370..790	CDD:441440	108/447 (24%)