DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ldd and abca1

DIOPT Version :10

Sequence 1:NP_001285513.1 Gene:ldd / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:XP_004910916.1 Gene:abca1 / 100491942 XenbaseID:XB-GENE-1001143 Length:2311 Species:Xenopus tropicalis


Alignment Length:2498 Identity:549/2498 - (21%)
Similarity:922/2498 - (36%) Gaps:764/2498 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPAAFSY 77
            ||.|:...|.||....::.:|||:.:|.:|..:||.|...|...|.:|.:.:|:.. .:|.....
 Frog    10 LLWKNFTYRRRQTLQLVVEVAWPLFIFFILISVRLSYPPYEQHECHFPNKAMPSAG-TLPWVQGI 73

  Fly    78 ICSIENRC--QPAHPYEE------------------------YSHWKEA---------------- 100
            ||:..|.|  .|. |.|.                        ||| |:.                
 Frog    74 ICNANNPCFRYPT-PGESPGVVGNFNRSIVSRLFTDARKLLLYSH-KDTSVKDMHKFLGNLHNYR 136

  Fly   101 --------------------------PLHSVIDVVNAFVTDER---------------------- 117
                                      |..:|.:::||.:..|:                      
 Frog   137 GTGLKLRDCLMDNEKFTDFLLKNISLPAVAVEEIMNAHLKPEQVLVSGFQIHLKDLCNSTRLAEY 201

  Fly   118 --LHKAVV---------------------ELAEKANFVSAITTLITSDRF----DIIRSNISEII 155
              :|..||                     |.....:.:..||...:|..|    ||..|.:..:.
 Frog   202 VTIHNEVVANLSQKIICALPEEKLNLLEQEFRSNVDLLKPITKEFSSKSFPFLKDITDSLLHSLA 266

  Fly   156 SLVPEI-------ERRMNYSFDIKHLFSNRET------FVKLGVLLCGHPFPNTDTIPLVNEILE 207
            .|..|:       |.|....|    |.|...|      :..:..::||||......|..:|...:
 Frog   267 DLAKEVMTMKSWAEMRQEVMF----LTSGNATASPSTLYQAVSRIVCGHPEGGGLKIKSLNWYED 327

  Fly   208 SE----------DFSQANDAEIDAMPTRRRRRYEDLPTDWRPTKYCKRLYRDVTSTNQGKLTWNT 262
            :.          |.|...|:::         .|::     ..|.||..|.:::.|:...::.|..
 Frog   328 NNYKALFGGGEGDNSTDEDSQV---------AYDN-----STTPYCNDLMQNLESSPLYRMIWRA 378

  Fly   263 IKPIIQGRILYTPANAMTESVVKFSNASFEELDRLKQL----------------SRAAATILTKL 311
            :||::.|:|||||:...|:.::...|.:|:||...:.|                |.....::..|
 Frog   379 LKPLLVGKILYTPSTPATQMLMSEVNKTFQELSVFRDLGAMWEEVRPQIKNFMESSQEMDLIRTL 443

  Fly   312 HTNATFQEAFDNLLK------------LAKSPL-VKSLVGDDFD----IGEIERVFEYIRTNQLI 359
            .||...:...|..|.            |||... |::..|..:.    :.|.:||          
 Frog   444 LTNKGSKTFLDQQLNSTGWTTENISRFLAKETADVETENGPFYSWREALNETDRV---------- 498

  Fly   360 YDILTTVADLMDCVSADRFEAVESVEELHKRAYELNQNKLFLAALNLEDVGLKQ------ASYRL 418
               :.|::..|:||:.|:.|.|.:.|.|..::.||...:.|.|.:...|:..::      ..|::
 Frog   499 ---VLTLSRFMECVNLDKLEPVATEEMLIDKSMELLNERKFWAGIVFMDMPEEETELPHHVKYKI 560

  Fly   419 HMDTDNTQPTFENRNRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKSKREEAGFAPEEDGP 482
            .||.||.:.|.:.::.:|.|||......|::| ..||..|:.:|:..||:               
 Frog   561 RMDIDNVERTNKIKDGYWDPGPRADPFEDMRYIWGGFSYLQDVVEQAIIR--------------- 610

  Fly   483 ESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTT 547
                                                                             
 Frog   611 ----------------------------------------------------------------- 610

  Fly   548 EEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQ 612
                   .||.|                 .||.|:                          |.:|
 Frog   611 -------VQTGV-----------------EKRTGI--------------------------YVQQ 625

  Fly   613 FPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVA 677
            .|||.:::|:|.|  .:::.:.:...|..:..||:.::..::.:|:|....||.|||......::
 Frog   626 MPYPCYVDDIFLR--VMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWLS 688

  Fly   678 WALMSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVA 742
            |.:.|.:.|.:..||:..:|.:|.:|.|::...:..:...|.:..||.|::.:..|:.||:.|..
 Frog   689 WFISSLIPLLMSAALLVLILKTGNLLPYSDPSVVFVFLSVFAVVTISQCFLISTIFSRANLAAAC 753

  Fly   743 SALLFFISLCPFIIVLMFD----AKLSVFESFLVDLSF---TTAFA----KG----WGELIRMEL 792
            ..:::|....|:::.:.:.    ..|.:|.|||..::|   ...||    :|    |..|:...|
 Frog   754 GGIIYFTLYLPYVLCVAWQDYVGYTLKIFASFLSPVAFGFGCEVFALLEEQGVGVQWDNLLESPL 818

  Fly   793 QQEGLTVRHLIQVGPARSECAMALLMFLLDLLLYAVI------------GLAYQRY--------- 836
            ::.|..:             ..:..|.|.|.|||.::            |:....|         
 Frog   819 EENGYNI-------------TTSGFMMLFDTLLYGIMTWYIEAVFPGQYGIPRPWYFPFTKSYWC 870

  Fly   837 ----KKTDNYSFVKVSRSQLDGK-------LGASLVNVSKLY--GSKCAVSNLSLDFARNQVSCL 888
                |:.:....|:...|::..:       ||.|:.|:.|:|  |.|.||..|:|:|...|::..
 Frog   871 GEECKEYNQPHTVQKGSSEVCMEEEPSHLPLGVSIQNLVKIYRNGKKVAVDGLTLNFYEGQITSF 935

  Fly   889 LGRNGAGKSTLIKLLTGQIRQSSGKVLLAGE----------HQVGVCWQDNILIPTLTAREHLQL 943
            ||.|||||:|.:.:|||....::|...:..:          ..:|||.|.|:|...||..||:..
 Frog   936 LGHNGAGKTTTMSILTGLFPPTTGTAYIMKKDIRTELNSIRQNLGVCPQHNVLFDALTVEEHIWF 1000

  Fly   944 YAQIKIPPGGSGGV--EEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVI 1006
            ||::|       |:  |::::|:.|.:..:.....:.|.:.|||||.:|:|.||:||:....|||
 Frog  1001 YARLK-------GLSEEKVKAEMEQMVNDVGLPHKKKYKTSQLSGGMQRKLSVALAFVGGSKVVI 1058

  Fly  1007 LDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHS------ 1065
            ||||..|||..:|:.||:|:.:.||||.:|.:||.||||..|.|.:.|:.:|::....|      
 Frog  1059 LDEPTAGVDPYSRRGIWELLIKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKN 1123

  Fly  1066 ------------RD----------------------SLQRLCTSNYSIRLRCADATGVTFVI--- 1093
                        ||                      |.|..|..:.|..:....|:|.|..:   
 Frog  1124 QLGTGYYLTLVKRDNDSSLSSCRNSSSTMSYLKKESSKQTACKQHPSPMIAAPSASGTTAAVITK 1188

  Fly  1094 -------QKAQQLLPQTQVTHSGA-------------------------------------ADYP 1114
                   ||.:....:..|:.|.:                                     .|..
 Frog  1189 HSKHTAGQKKEAKDREDSVSQSSSDAGLGSDHESDTMTIGLTDVSAISNLINKHVPEARLVEDIG 1253

  Fly  1115 HSLTINASYAEHLTPGAVEFLELLQS--------QVTAGSISDVEL----------------TTS 1155
            |.||....| |....||  |:||...        .:::..|:|..|                |:.
 Frog  1254 HELTYVLPY-EAAKEGA--FVELFHEIDDRLSDLGISSYGIADTTLEEIFLKVADDTGVDAETSD 1315

  Fly  1156 SSLE------------------QEFEQLNRNGEDAGPRRPASD-RSGVVAGPAMITDEPPTACKQ 1201
            .:|.                  .|.:..:.|..|..|....:| .||:....:..........:|
 Frog  1316 GTLPARRKRYAFGDHQSCLRPFTEDDAFDTNDSDMDPESRETDYLSGIDGKGSYQLKSWNLMRQQ 1380

  Fly  1202 FRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAM-------------------W-------FVSY 1240
            |..|:.|||.:..|:.:.....::|||:|.|.|:                   |       |.|.
 Frog  1381 FTALLWKRLLYAKRSRKGFFAQIVLPAVFVLIALVFSLIVPPFGKYPSLELEPWMYDEQYTFFSN 1445

  Fly  1241 RLEDD---------------FDTVLPLSRSLYPQTAQFLSHERATSF---------------SEK 1275
            ...||               |.|......|:...:......|.:|.|               .|.
 Frog  1446 DAPDDQGTQALLKALIDKPGFGTACMEGHSVMKVSCSGEEEEWSTQFVSQSVMDLFLNGNWTMEN 1510

  Fly  1276 LYPQLRTSCDH-----------LGECRVFNTSQQSYDWVLNSWGE---------YS--------- 1311
            ..|....|.|.           .|....|...|.:.|.:.|..|.         ||         
 Frog  1511 PSPSCECSSDKRKKMLPICPPGAGGLPPFQRRQNTSDILQNLTGRNISDYLVKTYSQIIEKSLKN 1575

  Fly  1312 -----ERRYGGYGLNGS---------------------------GAT------------------ 1326
                 |.||||:.|..|                           ||.                  
 Frog  1576 KIWVNEFRYGGFSLGASNSPALPPNEEVVASINHIKKRLELPQNGAANRFLDSFGAFMKGLDTKD 1640

  Fly  1327 ---VWYNNKGYHSMMAWLNDLNSELLRTTMNDSES----SILTLNEPWKLGFAELSTSSILRQAG 1384
               ||:||||:|::.|:||.:|:.:||:.:.:.|.    .|...|.|..|...:||..:::..:.
 Frog  1641 NVKVWFNNKGWHAVGAFLNVMNNAILRSKLREGEDPASYGITAFNHPLNLTKEQLSEVALMTTSV 1705

  Fly  1385 DGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVCL 1449
            |..:...::.|...|.||..|:|:.|||:..|..|.:.||..|.|||...|||....|:...:.:
 Frog  1706 DVLVSICVIFAMSFVPASFVVFLIQERVSKAKHMQCISGVKPVIYWLANFVWDMCNYVVPATLVI 1770

  Fly  1450 VVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMG 1514
            ::.:.|....:|....|..:..|.|.:.::..|.::.|..||...|.|.|.:...||.:.:....
 Frog  1771 IIFICFQQDSYVSSSNLPVLALLLLLYGWSITPLMYPASFIFKIPSTAYVVLTSVNLFIGINGSV 1835

  Fly  1515 IILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASD 1579
            ...:|.:..:... .:....|....||||...||.|.:::.||..:|....|:..:.:..|::.|
 Frog  1836 ATFVLELFTNNKL-SNINEILKSVLLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPMSWD 1899

  Fly  1580 LLGRHFTALLLVGVAALIINVLIEWHLL---RRLWQRVERLLD-----CTYRRELDKLGQLKLVN 1636
            |:||:..|:.:.||....|.::|::...   |.:..::..::|     ...|:.:::.|:..::.
 Frog  1900 LVGRNLFAMAVEGVVFFAITLMIQYRFFIKPRPVNAKLPPVVDEDEDVARERQRINEGGRNDILE 1964

  Fly  1637 IQSIFKSCVDTGEAVRAENLWLAYR-RGHYAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQ 1700
            ::.:.|                .|| :...||..:...:..||||||||.|||||:|.||:|||.
 Frog  1965 LKGLTK----------------IYRMKRKPAVDRLCVGIPPGECFGLLGVNGAGKTTTFKMLTGD 2013

  Fly  1701 LQPDVGQIYFEQPGI-----------SYCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLDR 1752
            .....|:.:.:...|           .||||.:.::.|||..|.:..|..|||:  :::.:..:.
 Frog  2014 TDVTAGEAFLKNHSILRNIHEVHQNMGYCPQFDAINELLTGREHLELYALLRGVPEKEVCKVAEW 2078

  Fly  1753 VLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLL 1817
            .:....|..|.:....|.||||:|||:.|:...|..|.|.:||||:.|||..|..::.....::.
 Frog  2079 AIRKLGLVKYSEKHAGNYSGGNKRKLSTAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVIK 2143

  Fly  1818 ARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHG-GYYAVTCFCG------PAQQ 1875
            ..|:|||||||:.|.|.||.|:|::..|:.....|.|.||:..| ||..:....|      |.::
 Frog  2144 EGRSVVLTSHSMEECEALCTRMAIMVNGRFKCLGSVQHLKNRFGDGYTIIVRIAGSNPDLKPVEE 2208

  Fly  1876 AILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILC--DVCVNVARFSLSR 1938
                 ..:...||:...:.:...|::  ::||..|     .|:.:|:||.  ...:::..:|:|:
 Frog  2209 -----FFSHAFPGSVLKEKHRSMLQY--QLRSSQS-----SLARIFSILSKNKKRLHIEDYSVSQ 2261

  Fly  1939 CRFETVFERIL-DSSESNGSN-GVHKDQ 1964
            ...:.||.... |.|:.:..: .:||:|
 Frog  2262 TTLDQVFVNFAKDQSDDDQKDLSLHKNQ 2289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lddNP_001285513.1 rim_protein 179..1867 CDD:130324 475/2099 (23%)
abca1XP_004910916.1 rim_protein 1..2272 CDD:130324 544/2479 (22%)

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