Protein Alignment CG34120 and abca1b

DIOPT Version :8

• Sequence 1: NP_001285513.1
• Gene: CG34120 / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Sequence 2: XP_005173137.1
• Gene: abca1b / 100136868
• ZFINID: ZDB-GENE-030131-9826
• Length: 2282
• Species: Danio rerio
• Alignment Length: 2479
• Identity: 550/2480 (22%)
• Similarity: 931/2480 (38%)
• Gaps: 727/2480 (29%)

  Fly    13 LLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPAAFSY 77
            ||.|:...|.||....|..:.||:.:|.:|..:||.|...|...|.:|.:.:|:.. .:|.....
Zfish    10 LLWKNFTYRRRQTLQLLTEIVWPLFIFFILIAVRLYYPPYEQHECHFPNKAMPSAG-TLPWIQGI 73

  Fly    78 ICSIENRCQPAHP-----------YEE------YSHWKEAPLHS-----------VIDVV----- 109
            :|:..|.|. .||           :.:      :|..|:..|:|           :||.|
Zfish    74 VCNANNPCF-RHPTPGESPGVVGNFNDSIISRLFSDAKKILLYSQNDKSLDGFKELIDAVKVMQN 137

  Fly   110 -----------------------NA-----FVT-----DERLHKAVV------------------ 123
                                   ||     :||     |..|.|.::
Zfish   138 NTAGFKLKDFLHEDETLSTFLLQNASFTENYVTNILDADVNLEKVLIKGFGVHLRDMCSSIKLED 202

  Fly   124 -------------------------ELAE---KAN--FVSAITTLITSDRFDIIR-----SNISE 153
                                     :.||   |:|  |:..:.:.|.::..|:.:     .|:.|
Zfish   203 FVTIPDTSVARFTQDMICRSPKNWLDQAESHFKSNLDFLKPVRSEIRTNATDVRKVTKATDNLLE 267

  Fly   154 II-SLVPEIERRMNYSFDIKH--LFSNRET-------FVKLGVLLCGHPFPNTDTIPLVNEILES 208
            .: ||..|:....::| |:::  ||.....       :..:..::||||......|..:|...:|
Zfish   268 SLGSLAVELASMRSWS-DLRNEILFLTENATGSPSLMYQAVSRIVCGHPEGGGLKIKSLNWYEDS 331

  Fly   209 ED---FSQANDAEIDAMPTRRRRRYEDLPTDWRPTKYCKRLYRDVTSTNQGKLTWNTIKPIIQGR 270
            ..   |...||::...:|.     |::     ..|.||..:.|::.::...::.|..:||::.|:
Zfish   332 NFQALFGNHNDSDDQPVPV-----YDN-----TTTPYCNSMMRNMEASPISRMIWRALKPLLMGK 386

  Fly   271 ILYTPANAMTESVVKFSNASFEELDRLKQLSRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKS 335
            |||||.:..|:.::...|.:|:||..|:.|.........|:.   .|.|. .|.:.|.::.|:.:
Zfish   387 ILYTPHSPATQKIIHEVNKTFQELGILRDLGGMWEEARPKVW---NFMEN-SNEMDLMRTLLLNN 447

  Fly   336 LVGDDFDI------GEIERVFEYI---------------------RTNQLIYDILTTVADLMDCV 373
            |..:.|..      ..:|.|..::                     .|:|.|    .:::..|:||
Zfish   448 LTANFFSAQLAGTQWSVEDVISFLSKHSEDTRPQGTAFTWRDVFNETDQAI----MSISRFMECV 508

  Fly   374 SADRFEAVESVEELHKRAYELNQNKLFLAALNLEDVGLKQA------SYRLHMDTDNTQPTFENR 432
            :.|:.|.|.:.|:|...:..|..|:.|.|.:...|:....:      :|::.||.||.:.|.:.:
Zfish   509 NLDKLEPVSTEEKLVNESMSLLDNRKFWAGIVFLDIPSNSSELPPNVNYKIRMDIDNVERTNKIK 573

  Fly   433 NRFWFPGPADSMVIDLKY-HRGFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRSLSGLFSIKQ 496
            :.:|.|||......||:| ..||..|:.:|:..||                   |:::|
Zfish   574 DGYWDPGPRADPFEDLRYIWGGFSYLQDVVEHSII-------------------RAVTG------ 613

  Fly   497 VENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRVTTEQTVVSG 561
                           |.|::|
Zfish   614 ---------------SKEKTG-------------------------------------------- 619

  Fly   562 DPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRG 626
                                                          .|.:|.|||.:::|:|.|
Zfish   620 ----------------------------------------------VYIQQMPYPCYVDDIFLR- 637

  Fly   627 LYLAQGVQVAYLLGLVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFA 691
             .:::.:.:...|..:..||:.::..::.:|:|....||.|||.......:|.:.|.:.|.:...
Zfish   638 -IMSRSMPLFMTLAWMYSVAIIIKGVVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLISAG 701

  Fly   692 LISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFII 756
            |:..:|..|.:|.|::...:..:..||.:..|..|::.:..|..||:.|....:::|....|:::
Zfish   702 LLVLLLKMGNLLPYSDPGVVFLFLGSFAVVTIMQCFLISTAFARANLAAACGGIIYFTLYLPYVL 766

  Fly   757 VLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQVGPARSE---CAMALLM 818
            .:.:...:......:..|....||..|.......|.|..|:...:|.. .|...:   ....|::
Zfish   767 CVAWQDYVGFAAKVIASLLSPVAFGFGCEYFALFEEQGVGIQWNNLFS-SPVEEDDYNLTTCLIL 830

  Fly   819 FLLDLLLYAVI------------GLAYQRY--------------------KKTDNYSFVKVSRSQ 851
            ...|..||.|:            |:....|                    .|..|...|.:....
Zfish   831 MYFDAFLYGVMTWYIETVFPGQYGIPRPWYFPFTKSYWFGENSTNNTAIHGKKSNAGAVCIEEEP 895

  Fly   852 LDGKLGASLVNVSKLY--GSKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKV 914
            ...|||..:.|:.|:|  |.|.||..|:|.|...|::..||.|||||:|.:.:|||....:||..
Zfish   896 THLKLGVYIENLVKVYRHGKKLAVDGLTLGFHEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTA 960

  Fly   915 LLAGE----------HQVGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGV--EEIRSEVAQT 967
            .:.|:          ..:|||.|.|:|...||..||:..||::|       |:  ||:::|:.|.
Zfish   961 YIMGKDIRSELSSIRQSLGVCPQHNVLFSMLTVEEHIWFYARLK-------GLSEEEVKAEMEQI 1018

  Fly   968 LQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQG 1032
            |............:.|||||.:|:|.||:||:....|||||||..|||..||:.||.|:.:.|.|
Zfish  1019 LSDTGLPHKRKSRTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLKYRAG 1083

  Fly  1033 RAVIFATHFMDEAKYLSDSLVIMRNGR---------------------IIAQHSRDSLQRLCTSN 1076
            |.::.:||.||||..|.|.:.|:.:|:                     ::.:::..||.....|:
Zfish  1084 RTILLSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGYYLTLVKKNTEPSLSSCRNSS 1148

  Fly  1077 YSIRL----------------------RCADATGVTF----VIQKAQQLLPQTQVTHSGAA---- 1111
            .::..                      ..|.|.|.::    |:.....::.:..:.|..||
Zfish  1149 STVSFVKKDDNASESSSDAGLGSDQESEAATAIGTSWPESPVVPVDVTIISRLILKHVPAARMVE 1213

  Fly  1112 DYPHSLTINASYAEHLTPGAVEFLELLQSQVTAGSISDVELTTSSSLEQEFEQLNRNGEDAG--- 1173
            |..|.:|....|........||....|..::....||...: :.::||:.|.::   .||:|
Zfish  1214 DQGHEITYVLPYESAKNGAFVELFHDLDDRLADLGISSYGV-SDTTLEEIFLKV---AEDSGVDT 1274

  Fly  1174 ------------PRRPA--SDRSGVVAGPAMITDEPPTAC------------------------- 1199
                        .||.|  :|....:   ..:|::....|
Zfish  1275 EMLSDGTLPVRRQRRHAFGADHQSCL---KPLTEDDSFDCNESEGDPESKETDYLSGSDGKGSYQ 1336

  Fly  1200 --------KQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAM-------------------W- 1236
                    :||..|:.|||.:..|:.:.....::|||:|...|:                   |
Zfish  1337 VKGWSLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLALNPWM 1401

  Fly  1237 ----FVSYRLEDDFD-TVLPLSRSLY------------------PQT---AQFLSHERATSFSEK 1275
                |:.:..:..:| :...|.|:|:                  |.|   .::.:.|...|..|.
Zfish  1402 YEEQFMFFSEDAPYDVSTHKLLRALFDDPGFGTRCMKGESIPDAPCTMGDEEWSTPEVPESIIEI 1466

  Fly  1276 L----------YPQLRTSCD----HLGEC------------------------------------ 1290
            |          .|....||:    .|.||
Zfish  1467 LTTRNWTMNDPSPACECSCNGKKKMLPECPAGAGGLPPPQIKISETETLQNLTGRNISDYLVKTY 1531

  Fly  1291 -RVFNTSQQSYDWVLNSWGEYSERRYGGYGL------------------------------NGSG 1324
             ::...|.::..||       :|.||||:.|                              :||.
Zfish  1532 AQIIGKSLKNKIWV-------NEFRYGGFSLGARSTQVLPPAEEIDDAISRVREIFQLGKDSGSA 1589

  Fly  1325 A--------------------TVWYNNKGYHSMMAWLNDLNSELLRTTM----NDSESSILTLNE 1365
            |                    .:|:||||:||:.|:||.:|:.:||..:    :.||..|...|.
Zfish  1590 ADRFLKSLSAFINGLDTKNNVKIWFNNKGWHSIGAFLNVMNNGILRANLPPGKDPSEFGITAYNH 1654

  Fly  1366 PWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYW 1430
            |..|...:||..:::..:.|..:...::.|...|.||..|:|:.||||..|..|.:.||....||
Zfish  1655 PLNLTKEQLSQVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKHMQFISGVQPYLYW 1719

  Fly  1431 LVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSS 1495
            |...:||....|:...:.:::.:.|....:|....|..:..|.|.:.::..|.::.|..:|...|
Zfish  1720 LANFLWDMCNYVVPATLVILIFVCFQQKAYVSATNLPVLALLLLLYGWSITPLMYPASFLFKIPS 1784

  Fly  1496 IAIVSIFCANLIVPL---VTMGIILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKN 1557
            .|.|.:...|:::.:   ::..::.:.|....|...|    .|....||||...||.|.:::.||
Zfish  1785 TAYVVLTSVNILIGINGSISTFVMELFGNHEIGGIND----ILKNVLLIFPHFCLGRGLIDMVKN 1845

  Fly  1558 YMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWH-------LLRRLWQRVE 1615
            ..:|....|:..:.::.||..|::|::..|:.:.||...||.|||::.       |..:|....|
Zfish  1846 QAMADALERFGENRFRSPLEWDMVGKNLFAMAVEGVVFFIITVLIQYRFFFEPKSLCPKLSPIGE 1910

  Fly  1616 RLLDCTYRRE--LDKLGQ---LKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGHYAVRNVNFSVQ 1675
            ...|....|:  :...||   |:|..:..::|                  |:...||..:...:.
Zfish  1911 EDEDVARERQRIMSGAGQGDILELRQLTKVYK------------------RKQKPAVDRLCVGIP 1957

  Fly  1676 RGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYFEQPGI-----------SYCPQSNPLDPLLT 1729
            .||||||||.|||||::.||:|||......|:.:.....|           .||||.:.::.|||
Zfish  1958 PGECFGLLGVNGAGKTSTFKMLTGDSVVTKGEAFIAGKSILREIDEVHQNMGYCPQFDAINDLLT 2022

  Fly  1730 TTECIRFYGRLRGIRDLDQFLDRVLDTYE-------LRPYKDVQVRNLSGGNRRKLTVAVTCCGC 1787
            ..|.:.||..|||:.:     :.|....|       |..|.|....:.||||.|||:.|::..|.
Zfish  2023 GREHLEFYAILRGVPE-----NEVCAVAEWGIRKLGLVKYVDKNAGSYSGGNMRKLSTAISLIGA 2082

  Fly  1788 TPTVLMDEPTSDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDS 1852
            .|.|.:||||:.|||..|..::..|..::...|:|||||||:.|.|.||.|:|::..|:.....|
Zfish  2083 PPVVFLDEPTTGMDPKARRALWNCIHSVIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGS 2147

  Fly  1853 PQRLKSEHG-GYYAVTCFCGPAQ--QAILSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDA 1914
            .|.||:..| ||..:....||..  |.:: :.:...|||:...:.:.:.|::    :.|.||..
Zfish  2148 VQHLKNRFGDGYTIILRVAGPDPDLQPVM-KFIESELPGSTLKEKHRNMLQY----QLPSSLTS- 2206

  Fly  1915 PLLSELFAILC--DVCVNVARFSLSRCRFETVFERILDSSESNGSNGVHKDQQQQVAKNDLPSKS 1977
              |:.:|:||.  ...:.:..:|:|:...:.||....            |||....:.:.:..|.
Zfish  2207 --LAHIFSILAKNKEFLRIEDYSVSQTTLDQVFVNFA------------KDQSDDHSDSSISRKG 2257

  Fly  1978 PAVGGTLET 1986
            .||...|.|
Zfish  2258 TAVNMALLT 2266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	31/139 (22%)
		ABC_subfamily_A	859..1073	CDD:213230	85/249 (34%)
		drrA	865..1162	CDD:130256	103/362 (28%)
		ABC2_membrane_3	1230..1601	CDD:289468	111/525 (21%)
		Mem_trans	1436..>1552	CDD:304621	26/119 (22%)
		ABC_subfamily_A	1651..1857	CDD:213230	79/224 (35%)
		drrA	1666..1945	CDD:130256	99/302 (33%)
abca1b	XP_005173137.1	rim_protein	1..2242	CDD:130324	542/2454 (22%)
		ABC_subfamily_A	902..1121	CDD:213230	83/226 (37%)
		ABC_subfamily_A	1932..2152	CDD:213230	82/243 (34%)
		DUF4162	2146..2238	CDD:290451	25/100 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG1131
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_126568
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810