DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stg1 and Cacng4

DIOPT Version :9

Sequence 1:	NP_001027082.1	Gene:	stg1 / 318064	FlyBaseID:	FBgn0064123	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_542423.1	Gene:	Cacng4 / 140725	RGDID:	628804	Length:	327	Species:	Rattus norvegicus

Alignment Length:	234	Identity:	69/234 - (29%)
Similarity:	109/234 - (46%)	Gaps:	42/234 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 MTTVNGGYLWLITPVAASISVAIVIAALAGPQWLFTEEKLPNANYNGTANFKALDDGAYITK--- 278
            |...:.|...|:|...|..:.:::..|:....||::...:    .||| |. .:|||....:
  Rat     1 MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTDYWLYSSAHI----CNGT-NL-TMDDGPPPRRARG 59

  Fly   279 -YTKSSLWILCTTLPGLDADSY--NCVKIDYFSNEG-YQPDPHDSTAAIPYTVTKSCPIFLAAGV 339
             .|.|.||.:| .:.|:    |  :|.:|::|..:. |.   |||:..:       ..|..|:.|
  Rat    60 DLTHSGLWRVC-CIEGI----YKGHCFRINHFPEDNDYD---HDSSEYL-------LRIVRASSV 109

  Fly   340 FLVISFIVFLI-PTC-------SHQNNLYYFSAGILFIVSGLVMLIGLIAYISILKAEIGSKLRP 396
            |.::|.|:.|: ..|       |.:||: ..||||||:.:||..:||:|.|||   :..|.....
  Rat   110 FPILSTILLLLGGLCIGAGRIYSRKNNI-VLSAGILFVAAGLSNIIGIIVYIS---SNTGDPSDK 170

  Fly   397 RSTLQPALIKVSYGQSFFLFVFGFIVTEFVGVLNIFLFI 435
            |.  :......:||.||:.....|||.|.||||.:.::|
  Rat   171 RD--EDKKNHYNYGWSFYFGALSFIVAETVGVLAVNIYI 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stg1	NP_001027082.1	PMP22_Claudin	235..429	CDD:304458	61/208 (29%)
Cacng4	NP_542423.1	PMP22_Claudin	6..202	CDD:419754	66/222 (30%)
Cacng4	NP_542423.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..262
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338191
Domainoid	1	1.000	59	1.000	Domainoid score	I10376
eggNOG	1	0.900	-	-		E1_28M76
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000345
OrthoInspector	1	1.000	-	-		otm45503
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12107
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.800