Protein Alignment CG32376 and TMPRSS2

DIOPT Version :10

• Sequence 1: NP_729271.1
• Gene: CG32376 / 318002
• FlyBaseID: FBgn0052376
• Length: 291
• Species: Drosophila melanogaster
• Sequence 2: NP_001128571.1
• Gene: TMPRSS2 / 7113
• HGNCID: 11876
• Length: 529
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 104/323 - (32%)
• Similarity: 146/323 - (45%)
• Gaps: 52/323 - (16%)

  Fly     3 QNFGSESEGRE--RDPSWSGYYKDNGTHYLLYGKPEDIAPT------PNFGNI------------ 47
            |:..:|:.||.  ||..    ||:|  .|...|..:|...|      .:.||:
Human   210 QDDWNENYGRAACRDMG----YKNN--FYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDAC 268

  Fly    48 SSNPFIN------ALEAQESFPTRIVNGKRIPCTEAPFQGSLHYEGYFVCGCVIINKIWILTAHH 106
            ||...::      .:....|..:|||.|:.......|:|.|||.:...|||..||...||:||.|
Human   269 SSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAH 333

  Fly   107 CFFGP---PEKYTVRVGSDQQR-----RGGQLRHVKKIVALAAYNDYTMRHDLAMMKLKSPVYFG 163
            |...|   |..:|...|..:|.     .|.|   |:|:::...|:..|..:|:|:|||:.|:.|.
Human   334 CVEKPLNNPWHWTAFAGILRQSFMFYGAGYQ---VEKVISHPNYDSKTKNNDIALMKLQKPLTFN 395

  Fly   164 KCVRPVKLPSTKTTKFPKKFV-VSGWGITSANAQNVQRYLRRVQIDYIKRSKCQKMYKKAGLKIY 227
            ..|:||.||:......|::.. :||||.|....: ....|...::..|:..:|...|....| |.
Human   396 DLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGK-TSEVLNAAKVLLIETQRCNSRYVYDNL-IT 458

  Fly   228 KDMICAS--RTNKDSCSGDSGGPL-TSRGVLY---GIVSWGIGCANKNYPGVYVNCKRYVPWI 284
            ..||||.  :.|.|||.||||||| ||:..::   |..|||.|||....||||.|...:..||
Human   459 PAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32376	NP_729271.1	Tryp_SPc	65..284	CDD:214473	84/233 (36%)
TMPRSS2	NP_001128571.1	LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:464747	17/78 (22%)
		Tryp_SPc	293..524	CDD:238113	85/234 (36%)