Protein Alignment tut and SYNCRIP

DIOPT Version :10

• Sequence 1: NP_729346.1
• Gene: tut / 317996
• FlyBaseID: FBgn0052364
• Length: 230
• Species: Drosophila melanogaster
• Sequence 2: NP_006363.4
• Gene: SYNCRIP / 10492
• HGNCID: 16918
• Length: 623
• Species: Homo sapiens
• Alignment Length: 169
• Identity: 39/169 - (23%)
• Similarity: 83/169 - (49%)
• Gaps: 23/169 - (13%)

  Fly    38 ELFLSCIPRNHSCSPRWIVEVASELGEVYIMRYKID-FSGNSRGYAYLQYINVDLKESAMQYLPM 101
            |:|:..|||:  .....:|.:..:.|.::.:|..:| .:|.:||||::.:..   ||:|.:.:.:
Human   163 EIFVGKIPRD--LFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCT---KEAAQEAVKL 222

  Fly   102 -------RFRQLCMCLRVEPSTNNRELVLKNVESSLRPWQVYQEMLKI-HPFTIVRVY----EYQ 154
                   ..:.:.:|:.|   .||| |.:.::..|....|:.:|..|: ...|.|.:|    :.:
Human   223 YNNHEIRSGKHIGVCISV---ANNR-LFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKK 283

  Fly   155 LDQFFYIFEYRNNDSAASAHQRVRN-SIRKFGEHAHISW 192
            .::.|...||.::.:||.|.:|:.: .::.:|....:.|
Human   284 KNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEW 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tut	NP_729346.1	RRM1_hnRNPR_like	36..115	CDD:409695	19/84 (23%)
SYNCRIP	NP_006363.4	NURR_hnRNPQ	23..107	CDD:410954
		hnRNP-R-Q	103..615	CDD:273732	39/169 (23%)
		Interaction with APOBEC1	400..561
		8 X 3 AA repeats of R-G-G	448..559
		3 X 4 AA repeats of Y-Y-G-Y	460..488
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..623
		Interaction with SMN. /evidence=ECO:0000269|PubMed:11574476	518..549
		Bipartite nuclear localization signal. /evidence=ECO:0000255	564..578