Protein Alignment Trf4-1 and TENT4A

DIOPT Version :10

• Sequence 1: NP_572490.2
• Gene: Trf4-1 / 31795
• FlyBaseID: FBgn0030049
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_008930.2
• Gene: TENT4A / 11044
• HGNCID: 16705
• Length: 792
• Species: Homo sapiens
• Alignment Length: 918
• Identity: 322/918 - (35%)
• Similarity: 425/918 - (46%)
• Gaps: 207/918 - (22%)

  Fly     1 MDPFVGWFQKEQEGPSLCTWLKIWETNAQEMGALLNQQLQQATTINGS--------------TSS 51
            |||.|.|.|.||:||:...|::||||:             |.....||              |::
Human     1 MDPRVAWIQPEQKGPANALWMQIWETS-------------QGVGRGGSGFASYFCLNSPALDTAA 52

  Fly    52 SSSSSNSGNNNNNNNNNIINNTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEILQQQQ 116
            ::.::..|                     :|....|.|..|.|..............|..|....
Human    53 AAGAAGRG---------------------SGGLGPALPAASPPPPGPTAPAALPPALLTALGPAA 96

  Fly   117 QQQQLNGTTQRNSTNINTTSGGSTSSSADSTTNRD--NNSPANSSSTNGPGAGTGTSTGAGGTGT 179
            :     |..:.:.:...::|..|:||:|:|.|...  ::|.::|:|...||.      |.||...
Human    97 E-----GARRLHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSASLGRPGG------GRGGAFF 150

  Fly   180 NSPATTASSTAATTTGPATSMSDTSNNPPQSTTTPASRTNSIYYNPSRKKRPENKAG--GAHYYM 242
            |. |..|.|...|..|          :|......||...:...::|.|:|| ||||.  |.:|.:
Human   151 NF-ADGAPSAPGTANG----------HPGPRGPAPAGSPSQHQFHPGRRKR-ENKASTYGLNYLL 203

  Fly   243 NNHMEMI----------AKYKGEPWRKPDYPYGEGVIGLHEEIEHFYQYVLPTPCEHAIRNEVVK 297
            :......          |...|.||:  ...|..|:.||||||..||.::.|.|.|.|:|.||||
Human   204 SGSRAAALSGGGGPGAQAPRPGTPWK--SRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREVVK 266

  Fly   298 RIEAVVHSIWPQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLRTLEFELVSRGIAEACTVRV 362
            |||.||..:||.|.|:|||||.|||:||||||||||.|.||:.||:.||..|....:||.|:::|
Human   267 RIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKV 331

  Fly   363 LDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVLEKLVLVLKQFLLLRDLNEV 427
            ||||:||||||||:||:|||||||||::||::||.||.:.:.|.:|..|:||||||||.||||||
Human   332 LDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEV 396

  Fly   428 FTGGISSYSLILMCISFLQMHPR-GIYHDTANLGVLLLEFFELYGRRFNYMKIGISIKNGGRYMP 491
            |||||||||||||.|||||:||| .......|||:||:||||||||.|||:|.||.||.||.|:.
Human   397 FTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIA 461

  Fly   492 KDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKCAYRVLALAVSPLNLLGIDPR 556
            |:|:.:.|..|:|||:|||||||.||||:||||||..||:|.|..||.||:.|||||.....:..
Human   462 KEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRD 526

  Fly   557 VNSILGRIIHITDDVIDYREWIRENF-----------EHLVVVDRISPLPTAAPTAYATANGAPK 610
            ..|.|||||.:|.:|||||.||:|.:           ..:.:.:||           ||.||...
Human   527 AESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERI-----------ATCNGEQT 580

  Fly   611 YVIMPSGAVVQQLYHHPVQVPTAHGHSHAHSHSHGHAHPGAHLCQPYV--TGTTVSAVTTTTTMA 673
            ....|.....|:|                          ...|..|.:  :|::.|:|:
Human   581 QNREPESPYGQRL--------------------------TLSLSSPQLLSSGSSASSVS------ 613

  Fly   674 VVTVGVSAGGVQQQQQQQNATAHTHSQQQTQNQSQSRHRRGSTSSGDDSEDSKDGDVVETTSSAQ 738
                  |..|..........|  |.|..|...|:.:....|..:    :.....|....|||..
Human   614 ------SLSGSDVDSDTPPCT--TPSVYQFSLQAPAPLMAGLPT----ALPMPSGKPQPTTSRT- 665

  Fly   739 EVVDIALSTPNGLANMSMPMP----------------------VHAVGMPASNSWSGNGNGNGNS 781
                 .:.|.|.....::|.|                      ||.:..||..|          :
Human   666 -----LIMTTNNQTRFTIPPPTLGVAPVPCRQAGVEGTASLKAVHHMSSPAIPS----------A 715

  Fly   782 SSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSGGNGFIRPGDVGTGSNRGGGDGSGGRNYN- 845
            |.:..|||.:.|.....|...::.     .|..|.|| |:   ..||:|..|......|...||
Human   716 SPNPLSSPHLYHKQHNGMKLSMKG-----SHGHTQGG-GY---SSVGSGGVRPPVGNRGHHQYNR 771

  Fly   846 ---QRNNH 850
               :|..|
Human   772 TGWRRKKH 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-1	NP_572490.2	TRF4	271..>583	CDD:227585	198/323 (61%)
TENT4A	NP_008930.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..191		37/179 (21%)
		TRF4	240..>545	CDD:227585	193/304 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..632		7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..792		14/52 (27%)