Protein Alignment CG32260 and TMPRSS2

DIOPT Version :10

• Sequence 1: NP_728942.1
• Gene: CG32260 / 317943
• FlyBaseID: FBgn0052260
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001128571.1
• Gene: TMPRSS2 / 7113
• HGNCID: 11876
• Length: 529
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 134/585 - (22%)
• Similarity: 222/585 - (37%)
• Gaps: 157/585 - (26%)

  Fly    41 PPPQGPPYPAPPPPPPPFQPIGPLIPPQPALPSTPAVIPT--------FQPTP-----PNPQTPV 92
            ||..||.|     ....:||..|       .|:.|.|:||        :.|:|     |...|..
Human    45 PPAIGPYY-----ENHGYQPENP-------YPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA 97

  Fly    93 TPPLITTSSSTTSSTTSTT----GLTTTTTAGTTL-----------PLPMPTCPSQPLVCLTGGA 142
            :.|::.|...:.|.|..|:    .|..|.|.||.|           ......|.:..:.|.:.|.
Human    98 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGT 162

  Fly   143 RPLPNCPCIDPRQQQNSPLLSSTGPQIGSDMMVFMPLNSGRRRRRRRRPQSCQDARSRPGS---- 203
                   ||:|...                                     |......||.
Human   163 -------CINPSNW-------------------------------------CDGVSHCPGGEDEN 183

  Fly   204 -CLPLTSCPQLMQEYQGQANEFHTF--------LGQSIC---GFDGSTFMVCCATDRSGNARSRK 256
             |:.|.....::|.|..|...:|..        .|::.|   |:..:.:......|.||:.
Human   184 RCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGST---- 244

  Fly   257 DVFVTTAAPFGFFHFSPLSGGSTATPMVFQPTPPLSQVVSPSFYPPPPPPPPNNAPRESATCGI- 320
                      .|...:..:|.......::......|:.|               .......||:
Human   245 ----------SFMKLNTSAGNVDIYKKLYHSDACSSKAV---------------VSLRCIACGVN 284

  Fly   321 -SGATSNRVVGGMEARKGAYPWIAALGYFEENNRNALKFLCGGSLIHSRYVITSAHCI-----NP 379
             :.:..:|:|||..|..||:||..:|     :.:|.  .:||||:|...:::|:|||:     ||
Human   285 LNSSRQSRIVGGESALPGAWPWQVSL-----HVQNV--HVCGGSIITPEWIVTAAHCVEKPLNNP 342

  Fly   380 MLTLVRLGAHDLSQPAESGAMDLRIRRTVVHEHFDLNSISNDIALIELNVVGALPGNISPICLPE 444
            .......|.  |.|.........::.:.:.|.::|..:.:|||||::|.........:.|:|||.
Human   343 WHWTAFAGI--LRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPN 405

  Fly   445 AAKFMQQDFVGMNPFVAGWGAVKHQGVTSQVLRDAQVPIVSRHSCEQSYKSIFQFVQFSDKVLCA 509
            ....:|.:.:   .:::||||.:.:|.||:||..|:|.::....|...|  ::..: .:..::||
Human   406 PGMMLQPEQL---CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRY--VYDNL-ITPAMICA 464

  Fly   510 G--SSSVDACQGDSGGPLMMPQLEGNVYRFYLLGLVSFGYECARPNFPGVYTRVASYVPWIKKHI 572
            |  ..:||:|||||||||:..  :.|::  :|:|..|:|..||:...||||..|..:..||.:.:
Human   465 GFLQGNVDSCQGDSGGPLVTS--KNNIW--WLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM 525

  Fly   573  572
            Human   526  525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32260	NP_728942.1	CLIP	194..244	CDD:463440	12/65 (18%)
		Tryp_SPc	328..571	CDD:238113	78/249 (31%)
TMPRSS2	NP_001128571.1	LDLa	150..185	CDD:238060	9/78 (12%)
		SRCR_2	190..283	CDD:464747	15/121 (12%)
		Tryp_SPc	293..524	CDD:238113	78/249 (31%)