Protein Alignment CG32260 and HGFAC

DIOPT Version :10

• Sequence 1: NP_728942.1
• Gene: CG32260 / 317943
• FlyBaseID: FBgn0052260
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001284368.1
• Gene: HGFAC / 3083
• HGNCID: 4894
• Length: 662
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 180/690 - (26%)
• Similarity: 249/690 - (36%)
• Gaps: 209/690 - (30%)

  Fly    47 PYPAPPPPPPPF----------------QPIGPLI-PPQPALPSTPAVIPTFQPTPPNPQTPVT- 93
            |.|.|||...||                ||.|... .|:|...:||| |||...|....:||.|
Human     8 PSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPA-IPTILVTSVTSETPATS 71

  Fly    94 --------------PPLITTSSSTTSSTTSTTG--------------LTTTTTAGTTL------- 123
                          ||....|||:..:...|..              |...|:.|:..
Human    72 APEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLHACTSEGSAHRKWCATT 136

  Fly   124 ---------------------PLPMPTCPSQPLVCLTGGARPLPNCPCI---DPRQQQNSPLLSS 164
                                 |..:..|.|.|  ||.||:       |.   ||:....|...:.
Human   137 HNYDRDRAWGYCVEATPPPGGPAALDPCASGP--CLNGGS-------CSNTQDPQSYHCSCPRAF 192

  Fly   165 TGPQIGS----DMMVFMPLNSGRRRRRRRRPQ----SCQDAR-----SRPGSCLPLTSCPQLMQE 216
            ||...|:    |...:..|..|.|..|.|:..    .|...|     :|..:||   |.|.|
Human   193 TGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACL---SSPCL--- 251

  Fly   217 YQGQANEFHTFLGQSIC----GFDGSTFMVCCATDRS-----GNARSRKDVFVTTAAPFGFFHF- 271
             .|.........|.::|    ||.|.    .|..:..     ||....:.|..|:|:......:
Human   252 -NGGTCHLIVATGTTVCACPPGFAGR----LCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWN 311

  Fly   272 SPL--------SGGSTAT----PMVFQPTP-----PLSQVV------------------------ 295
            |.|        |.|:.|.    |..:...|     |...||
Human   312 SDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACDLETEGRES 376

  Fly   296 ------SPSFYPPPPPPPPNNAPRESATCGISGATSN----RVVGGMEARKGAYPWIAALGYFEE 350
                  ||......|.|.   :|...| ||.......    |::||..:..|::||:||: |..:
Human   377 LTRVQLSPDLLATLPEPA---SPGRQA-CGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAI-YIGD 436

  Fly   351 NNRNALKFLCGGSLIHSRYVITSAHCIN---PMLTL-VRLGAHDLSQPAESGAMDLRIRRTVVHE 411
            :       .|.|||:|:.:|:::|||.:   |..:: |.||.|..::..:. .....|.:.:.:.
Human   437 S-------FCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDV-TQTFGIEKYIPYT 493

  Fly   412 HFDL-NSISNDIALIELNVVGALPGN----ISPICLPEAAKFMQQDFVGMNPFVAGWGAVKH--Q 469
            .:.: |...:|:.||.|...|.....    :.||||||......   .|....:||||.:..  .
Human   494 LYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFP---AGHKCQIAGWGHLDENVS 555

  Fly   470 GVTSQVLRDAQVPIVSRHSCEQSYKSIFQFVQFSDKVLCAG--SSSVDACQGDSGGPLMMPQLEG 532
            |.:|. ||:|.||:|:.|.|  |...::. ...|..:||||  ....|||||||||||   ..|.
Human   556 GYSSS-LREALVPLVADHKC--SSPEVYG-ADISPNMLCAGYFDCKSDACQGDSGGPL---ACEK 613

  Fly   533 NVYRFYLLGLVSFGYECARPNFPGVYTRVASYVPWIKKHI 572
            |... ||.|::|:|..|.|.:.||||||||:||.||...|
Human   614 NGVA-YLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRI 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32260	NP_728942.1	CLIP	194..244	CDD:463440	14/58 (24%)
		Tryp_SPc	328..571	CDD:238113	88/255 (35%)
HGFAC	NP_001284368.1	PRK14954	<32..>100	CDD:184918	20/68 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..102		8/37 (22%)
		FN2	102..148	CDD:128373	4/45 (9%)
		EGF_CA	162..197	CDD:238011	13/43 (30%)
		FN1	200..240	CDD:238018	8/39 (21%)
		EGF_CA	245..278	CDD:238011	11/43 (26%)
		Kringle	286..367	CDD:395005	15/80 (19%)
		Tryp_SPc	415..650	CDD:238113	88/254 (35%)