DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32221 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_730456.2	Gene:	CG32221 / 317924	FlyBaseID:	FBgn0052221	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	XP_038962809.1	Gene:	Fbxl13 / 100125363	RGDID:	1642425	Length:	823	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	85/428 - (19%)
Similarity:	158/428 - (36%)	Gaps:	125/428 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LDPSSLLFIFKLLSLEDQLHLARCCRIFRDAFLRLHRHDFQDVVD----KDMS----IRTLEDWR 66
            |...:::.||..|:.:|   |..|.::.|.....:.|....:.:|    |:::    :.||:.||
  Rat   245 LPDQAVVQIFVYLTFKD---LVSCSQVNRSWMSMIQRGSLWNSIDFSTVKNIADRCVVTTLQKWR 306

  Fly    67 TFLWLCGSRIGTLESHFDDDHPLQLLPMISRHCY----RLKSISIYNATVARAQPYLLRMSSLEK 127
                                  |.:|.:..|.|.    .|||:|              ...:|::
  Rat   307 ----------------------LNVLRLNFRGCVLRAKTLKSVS--------------HCKNLQE 335

  Fly   128 VHVRNYKSTSKDLIKAIGIHLPRVNSLSL-----------------ESFERKELQEVRQFSEMLE 175
            ::|.:..|.:.:.::.|....|.|..|:|                 .:.:...|...|:|::.
  Rat   336 LNVSDCPSFTDESMRHISEGCPGVLYLNLSNTTITNRTMRLLPRYFHNLQNLSLAYCRKFTDK-- 398

  Fly   176 LGLYDDVTASEFATIVKPMRKLRCLQLRNAKRFLTTSNLRMLATNCRHLEKLTFND----CDADL 236
             ||       ::..:.....||..|.|....: ::....|.:|.:|..:..||.||    .|..:
  Rat   399 -GL-------QYLNLGNGCHKLIYLDLSGCTQ-ISVQGFRNIANSCTGIMHLTINDMPTLTDNCV 454

  Fly   237 LVL----PQFVNLKYLQLYCSEDMKTRLFKALAKSQCSIQLEYLILHRKRWID---EEQAQYISA 294
            .||    |:..::.::.   |..:....||||  |.|.:: :......||..|   :...:....
  Rat   455 KVLVEKCPRISSVVFIG---SPHISDCAFKAL--SACDLK-KIRFEGNKRITDACFKSVDRNYPG 513

  Fly   295 LKCLRWLVCKPRDDLCVHHLAKLSRLECLSIQSAREIGETQL-------------SLLVAN---- 342
            :..:..:.||...|..:..|:.|.:|..|::.:...||:..|             .|.:||
  Rat   514 ISHIYMVDCKGLTDSSLKSLSVLKQLTVLNLTNCVRIGDIGLRQFFDGPASVKLRELNLANCSLL 578

  Fly   343 --------NER---LRYLNICYCLGITDAFVLDTLASL 369
                    :||   |.|||:..|..:|| ..::.:||:
  Rat   579 GDTSVIRLSERCPNLHYLNLRNCEHLTD-LAIEYIASM 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32221	NP_730456.2	leucine-rich repeat	197..223	CDD:275381	6/25 (24%)
		leucine-rich repeat	224..244	CDD:275381	8/27 (30%)
		leucine-rich repeat	245..272	CDD:275381	7/26 (27%)
		leucine-rich repeat	273..297	CDD:275381	3/26 (12%)
		leucine-rich repeat	298..319	CDD:275381	5/20 (25%)
		leucine-rich repeat	320..345	CDD:275381	8/49 (16%)
		leucine-rich repeat	346..372	CDD:275381	9/24 (38%)
Fbxl13	XP_038962809.1	Sfi1	<134..>214	CDD:400658
		F-box-like	242..286	CDD:403981	9/43 (21%)
		leucine-rich repeat	257..270	CDD:275381	4/15 (27%)
		leucine-rich repeat	282..308	CDD:275381	6/47 (13%)
		AMN1	308..477	CDD:187754	36/196 (18%)
		leucine-rich repeat	309..332	CDD:275381	7/36 (19%)
		leucine-rich repeat	333..358	CDD:275381	4/24 (17%)
		leucine-rich repeat	359..383	CDD:275381	3/23 (13%)
		leucine-rich repeat	384..402	CDD:275381	5/27 (19%)
		leucine-rich repeat	412..437	CDD:275381	6/25 (24%)
		leucine-rich repeat	438..463	CDD:275381	7/24 (29%)
		leucine-rich repeat	464..486	CDD:275381	6/26 (23%)
		leucine-rich repeat	488..513	CDD:275381	3/25 (12%)
		leucine-rich repeat	514..534	CDD:275381	3/19 (16%)
		AMN1	525..733	CDD:187754	22/92 (24%)
		leucine-rich repeat	539..563	CDD:275381	5/23 (22%)
		leucine-rich repeat	567..592	CDD:275381	5/24 (21%)
		leucine-rich repeat	593..617	CDD:275381	9/24 (38%)
		leucine-rich repeat	618..641	CDD:275381
		leucine-rich repeat	642..667	CDD:275381
		leucine-rich repeat	668..693	CDD:275381
		leucine-rich repeat	694..719	CDD:275381
		leucine-rich repeat	720..745	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000