DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32110 and Senp18

DIOPT Version :9

Sequence 1:	NP_729837.1	Gene:	CG32110 / 317858	FlyBaseID:	FBgn0052110	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001002834.1	Gene:	Senp18 / 408222	RGDID:	1303230	Length:	475	Species:	Rattus norvegicus

Alignment Length:	455	Identity:	136/455 - (29%)
Similarity:	214/455 - (47%)	Gaps:	86/455 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TKECQD-YPMAKTMPVLKQPENFQEQEEDVVMAVQEKLKFFRKLTSNGPAVPTPLK------VVE 76
            ::.||| ..|....|...:.:..||.::..:...|......:|....|.....||:      |||
  Rat    42 SRNCQDGAQMVFQKPGKARKKTHQEHQDQKLNKEQPGKGQGQKTQDEGSGNIKPLEGLPDQAVVE 106

  Fly    77 KEDIGHKEIPKVVKKVDRKTKLLQAIPAVFKHSHNRRFRRSLF-------LRSNYIEQFRRWTDQ 134
            |...|.|     .:|  |...:||..|   :...|.:..|||.       :||:.......::|.
  Rat   107 KSTEGGK-----CRK--RPYSVLQEKP---QSPQNEKHARSLEHLQGGHPVRSDPHRPHPTFSDT 161

  Fly   135 KNKL---------------NRKRLNEAHQLCLKAKHERIACE---------------------ID 163
            .|..               :|:...|.    |..|.|:...|                     :|
  Rat   162 SNNKGGMPGHPHGRETAHGDRQPSTEV----LSTKREKRCAEEKCVRGNSLEHGLPGTANANILD 222

  Fly   164 RYKKLILKQSVHVIEDIRISSELIPLTKEHHDRLMELSKY------------PLQQVIVAKFNLD 216
            .....:|...|.|     ::.|...|.::.:::..|.:|.            ..::::...|.|.
  Rat   223 SGGGRLLPDKVAV-----VAGEKNALPEQENNQEKEFTKEMEKEVEKALGPGAQEEILSTGFKLK 282

  Fly   217 ICGSDIKILTSGGWLNDKIINFYMNLLVERSEKRPGTVPSVYAMSTFFVPRLLQSGFDGVKRWTR 281
            |...|::.|.:|.||||::|||||||||:|:| .|| .|:::|.||||..:|...|::.||||||
  Rat   283 ITRGDMQTLKNGQWLNDEVINFYMNLLVQRNE-NPG-YPALHAFSTFFYAKLKHGGYNSVKRWTR 345

  Fly   282 KVDLFSMDLILVPVHQMLVHWCLVIIDLPAKTMLYYNSRGRGDPNLMRALVKYLQMESEDKLGLC 346
            .::||..:|||||:||. |||.||:|||..::::|.:|.|:...|:...:..|||.||:.:..:.
  Rat   346 GINLFEKELILVPIHQR-VHWSLVVIDLRKRSIVYLDSMGQTGKNICETIFHYLQNESKTRRNME 409

  Fly   347 LDTSEFRIED--AQNVPQQDNMNDCGVFVCMFAEYLTRDAPITFSKKDMKYFRTKMVLELTGDQL 409
            ||..|::...  :|.:|||.|.:|||:|.|.:|:|::||.|:|||::.|..||.:||.|:....|
  Rat   410 LDPVEWKQYSLTSQEIPQQLNGSDCGMFTCKYADYISRDQPVTFSQQHMPLFRKRMVWEILHSHL 474

Fly 410 409
Rat 475 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32110	NP_729837.1	Peptidase_C48	230..400	CDD:280975	81/171 (47%)
Senp18	NP_001002834.1	Peptidase_C48	<244..470	CDD:304959	92/228 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339699
Domainoid	1	1.000	189	1.000	Domainoid score	I3195
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3812
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8978
orthoMCL	1	0.900	-	-		OOG6_130490
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X425
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760