DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32110 and Semp2l1

DIOPT Version :9

Sequence 1:	NP_729837.1	Gene:	CG32110 / 317858	FlyBaseID:	FBgn0052110	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001157758.1	Gene:	Semp2l1 / 408191	MGIID:	3644687	Length:	478	Species:	Mus musculus

Alignment Length:	463	Identity:	137/463 - (29%)
Similarity:	225/463 - (48%)	Gaps:	93/463 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KECQDYPMAKTMPVLKQPENFQ----EQEEDVVMAVQEKLK-FFRKLTSNGPAVPTPLKVVE--K 77
            ::|||    .|..|.|.|...|    ::..|:.:|:::..| ..||.....|..|.||::.|  .
Mouse    35 RKCQD----GTTMVFKVPGKAQKMTPQEPPDLELAIEQFSKGQVRKSQGETPNQPKPLELTEGPP 95

  Fly    78 EDI-----------GHK------EIPKVVKKVDRKTKLLQAIPAVF-----------KHSHNRRF 114
            |.:           |||      |..:.:.:.::|.:|||.:..:.           :.||..
Mouse    96 EQVVTGRAPADSGKGHKRPYSAMEENEQIPQKEKKRRLLQNLKLILIKAGKIKGGESEDSHGS-- 158

  Fly   115 RRSLFLRSNYIEQFRRWTDQKNKLNRKRL---NEAHQLCLK--AKHERIAC---EIDRYKKLILK 171
                       |...|..:....:..|..   :|..:.|.:  :..|:..|   |..|...|...
Mouse   159 -----------ETTLRDPEPSTVVALKECLSPDEREKCCFEETSVTEKKGCVKVEGRRGNSLEPG 212

  Fly   172 QSVHVIEDIRISSELIP-------------LTKEHH---DRLMELSK------------YPLQQV 208
            ....:|.|....:.|:|             ...|.|   |:::::::            .|.:::
Mouse   213 TQAQIILDSSRGNSLLPNKMAVLAAQKKPLRDHEKHREMDQILDITEDMEKEIENALGPGPQEEI 277

  Fly   209 IVAKFNLDICGSDIKILTSGGWLNDKIINFYMNLLVERSEKRPGTVPSVYAMSTFFVPRLLQSGF 273
            :.::|.|.|...||:.|.:|.||||::|||||||||||:|.:  ..|:::..||||.|:|..||:
Mouse   278 LSSRFKLLITRGDIQTLKNGQWLNDEVINFYMNLLVERNENQ--GYPALHVFSTFFYPKLKHSGY 340

  Fly   274 DGVKRWTRKVDLFSMDLILVPVHQMLVHWCLVIIDLPAKTMLYYNSRGRGDPNLMRALVKYLQME 338
            ..||||||.::||..:|||||:||.| ||.||:|||..:::.|::|.|:...::...:.:|||.|
Mouse   341 SSVKRWTRGINLFEKELILVPIHQRL-HWSLVVIDLRKQSIAYFDSIGQTGKSICETIFQYLQNE 404

  Fly   339 SEDKLGLCLDTSEFRIED--AQNVPQQDNMNDCGVFVCMFAEYLTRDAPITFSKKDMKYFRTKMV 401
            |:.:..:.||..|::...  ::.:|.|.|.:|||:|.|.:|:|:.||.|:|||::.|..||.:||
Mouse   405 SKTRRNIELDPLEWKQYSMASEEIPLQMNGSDCGMFTCKYADYIARDQPVTFSQQHMPTFRKRMV 469

  Fly   402 LELTGDQL 409
            .|:...||
Mouse   470 WEILHSQL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32110	NP_729837.1	Peptidase_C48	230..400	CDD:280975	78/171 (46%)
Semp2l1	NP_001157758.1	Peptidase_C48	<231..473	CDD:304959	92/244 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836054
Domainoid	1	1.000	189	1.000	Domainoid score	I3284
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8739
orthoMCL	1	0.900	-	-		OOG6_130490
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1601
SonicParanoid	1	1.000	-	-		X425
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730