DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32110 and SENP6

DIOPT Version :9

Sequence 1:	NP_729837.1	Gene:	CG32110 / 317858	FlyBaseID:	FBgn0052110	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_056386.2	Gene:	SENP6 / 26054	HGNCID:	20944	Length:	1112	Species:	Homo sapiens

Alignment Length:	387	Identity:	86/387 - (22%)
Similarity:	150/387 - (38%)	Gaps:	117/387 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FDLITKECQDYPMAKTMPVLKQPENFQEQEEDVVMAVQEKLKFFRKLTSNGPAVPTPLKVVEKED 79
            ||.:...|:...:.....:|.:|         |:..:.     |.|:..:.|. ..|::::
Human   440 FDSVILNCRSIRVGTLFRLLIEP---------VIFCLD-----FIKIQLDEPD-HDPVEII---- 485

  Fly    80 IGHKEIPKV----VKKVDRKTKLLQAIPAVFKHSHNRRFRRSLFLRSNYIEQFRRWTDQK--NKL 138
            :...::.|.    |:|:  ....|||||||::       :.|:.|:.|  ::.:.|.|.|  |||
Human   486 LNTSDLTKCEWCNVRKL--PVVFLQAIPAVYQ-------KLSIQLQMN--KEDKVWNDCKGVNKL 539

  Fly   139 NRKRLNEAHQLCL------------------------------------KAKHERIACEIDRYKK 167
            .  .|.|.:.:.:                                    :|....:|| ...|::
Human   540 T--NLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVAC-TRTYEE 601

  Fly   168 LI---LKQSVHVIEDIRISSELIPLTKEHHDRLMELSKY---------PLQQVIV-----AKFNL 215
            .|   ..|..:.|:.:...|::...:|:......|..:.         |::::||     ||..:
Human   602 SIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPPPAKGGI 666

  Fly   216 DICGSDIKILTSGGWLNDKIINFYMNLLV-ERSEKRPGTVPSVYAMSTFFVPRL----------- 268
            .:...|:..|..|.:|||.||:||:..|| |:.:|.  ....::..|:||..||
Human   667 SVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKE--DADRIHIFSSFFYKRLNQRERRNHETT 729

  Fly   269 ---LQSGFDG-VKRWTRKVDLFSMDLILVPVHQMLVHWCLVIIDLPAKTMLYYNSRGRGDPN 326
               :|....| ||.|||.||:|..|.|.||::: ..||.|.::..|......|      :||
Human   730 NLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNE-AAHWFLAVVCFPGLEKPKY------EPN 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32110	NP_729837.1	Peptidase_C48	230..400	CDD:280975	37/113 (33%)
SENP6	NP_056386.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..219
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..368
		Protease	666..1112		40/128 (31%)
		Peptidase_C48	680..>825	CDD:304959	37/114 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	870..905
		Peptidase_C48	<973..1049	CDD:304959
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1082..1112
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810