Protein Alignment Trxr1 and GSR

DIOPT Version :10

• Sequence 1: NP_727251.1
• Gene: Trxr1 / 31760
• FlyBaseID: FBgn0020653
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_000628.2
• Gene: GSR / 2936
• HGNCID: 4623
• Length: 522
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 178/490 - (36%)
• Similarity: 261/490 - (53%)
• Gaps: 30/490 - (6%)

  Fly   101 QPVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNV 165
            ||.......|....||.:||||||.|||.|:.|...|||.|.::..|          :|||||||
Human    51 QPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK----------LGGTCVNV 105

  Fly   166 GCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 230
            ||:|||:|...::..|.:|:.|.||:...|. |.:|..:.:....::..:|.:.:.:|....:|.
Human   106 GCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEI 169

  Fly   231 INGLGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYP---DIPGAVEYGITSDDLFSLDREP 292
            |.|..:|........:: ||:: .||...:||.||.|..|   .|||| ..|||||..|.|:..|
Human   170 IRGHAAFTSDPKPTIEV-SGKK-YTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELP 231

  Fly   293 GKTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEERGIPFLRKTVPL 356
            |::::||||||.:|.||.|..||.:.::|:| ..|||.||..::......:|..|:..|:.:...
Human   232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVK 296

  Fly   357 SVEKQDDGKLLVKYKNVETGE-----EAEDVYDTVLWAIGRKGLVDDLNLPNAGV-TVQKDKIPV 415
            .|:|...| |.|.......|.     ...|| |.:||||||.....||:|...|: |..|..|.|
Human   297 EVKKTLSG-LEVSMVTAVPGRLPVMTMIPDV-DCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV 359

  Fly   416 DSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYG-GSTQRMDYKDVATTVFTPLEYAC 479
            |..:.|||..||||||:. ||..|||||:.|||.||.||:. ....::||.::.|.||:......
Human   360 DEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGT 423

  Fly   480 VGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGE 544
            |||:|::|:.::|.:.::.:...:.|....:.::..: |.:|.|. .:.:::|.|:|..|....|
Human   424 VGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CVMKMVC-ANKEEKVVGIHMQGLGCDE 486

  Fly   545 VIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 579
            ::||||.|:|.|.|.....|||.||||::||...|
Human   487 MLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trxr1	NP_727251.1	DAO	59..>160	CDD:477422	21/58 (36%)
		TGR	113..595	CDD:273624	175/478 (37%)
GSR	NP_000628.2	gluta_reduc_1	63..522	CDD:273614	175/478 (37%)