Protein Alignment CG18262 and Zfp458

DIOPT Version :10

• Sequence 1: NP_572453.1
• Gene: CG18262 / 31745
• FlyBaseID: FBgn0030012
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001136434.1
• Gene: Zfp458 / 499563
• RGDID: 1559684
• Length: 752
• Species: Rattus norvegicus
• Alignment Length: 455
• Identity: 129/455 - (28%)
• Similarity: 190/455 - (41%)
• Gaps: 85/455 - (18%)

  Fly    34 CLLCDQ-------RLPLDGYPE-HFRLK-----------HFTNSSSSLCSN----ELESDPIAQD 75
            |.:|::       :..|..:.: |.|.|           ||.:..|:...|    :|.:..|...
  Rat    80 CYMCEECGQVFEWKKVLQNHQKIHLRAKPYKCEECGKSFHFPSLLSAHKRNHTGEKLYNCEICCK 144

  Fly    76 VVEVQGNEELHEELAKEASPDLEEEEEEKEEGSKRQHYQRAAAMKNTLVETREDLLDIELDWTGG 140
            .........||:.:.....|      .|.|..||..||. :...:|.:|.|.|.....|   ..|
  Rat   145 AFHASSLLSLHKRIHTGQKP------HESENYSKDFHYP-SLLSQNKVVHTGEKSYQCE---DHG 199

  Fly   141 EQ-------SEHNETHEEEE-------GESDDDDTKDSN----DTKDMLFQCDQCDRAYNTKRSL 187
            :.       |:|.:.|..|:       |::.|..::.||    .|.:..::|:.||||::....|
  Rat   200 KTFHYPSTFSKHKKIHTGEKPHKCEVCGKAFDYPSRLSNHKRIHTGEKPYKCEVCDRAFHDPSKL 264

  Fly   188 QSHRRLKHSEANGGSLDKSASERNSKKRKGPPKVYKCNEEACNQTFRTERDLRGHRWKHTG---I 249
            ..|:.:...|                      |.|||  :.|.:.|.....|..|:..||.   .
  Rat   265 SQHKIIHTGE----------------------KPYKC--DVCGKAFHYPSILSKHKIIHTEENLC 305

  Fly   250 FCDICGKPFTQSGNMMRHRQRHSGIKPHKCPECDATFYTQKELSSHSICHTGRMPCICEVCGRPC 314
            .||||||.|.....:.:|:..|:|.||:||.:|...||....||.|...|||..|..|||||:..
  Rat   306 KCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGKAFYYPSRLSRHKKIHTGEKPYKCEVCGKAF 370

  Fly   315 RDRGVLTAHMRRHTGERPAKCEVCGKAFYSFHDLNVHAVSHTNLRPFVCDVCGSTFQRKKALRVH 379
            ....:|:.|...||.|.|.|||||||||.....|:.|...||..:|:.|:|||:.|....:||.|
  Rat   371 HYLSILSKHKIVHTEENPYKCEVCGKAFDYPSRLSNHKKIHTEEKPYKCEVCGNAFCFSSSLRKH 435

  Fly   380 KLLHSEQRKYACKLCGKTFAQSGGLNAHMRSHDPAR-----VKGAVKPLPQ--SVTIEVIEGKSP 437
            |::|:.::.|.|::|||.|.....|:.|.:.|...:     |.|.....|.  ||...:..|:.|
  Rat   436 KIIHTGEKPYKCEVCGKAFGSPSRLSKHKKIHTEEKPYKCEVCGKAFHFPSLLSVHKRIHTGEKP 500

  Fly   438  437
              Rat   501  500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18262	NP_572453.1	COG5236	<222..>313	CDD:227561	38/93 (41%)
		C2H2 Zn finger	224..246	CDD:275368	5/21 (24%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		zf-H2C2_2	263..288	CDD:463886	9/24 (38%)
		C2H2 Zn finger	279..327	CDD:275368	18/47 (38%)
		zf-H2C2_2	320..342	CDD:463886	13/21 (62%)
		C2H2 Zn finger	335..355	CDD:275368	10/19 (53%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		zf-C2H2	389..411	CDD:395048	8/21 (38%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
Zfp458	NP_001136434.1	KRAB	5..63	CDD:214630
		C2H2 Zn finger	83..103	CDD:275368	2/19 (11%)
		COG5048	107..520	CDD:227381	124/428 (29%)
		C2H2 Zn finger	111..131	CDD:275368	3/19 (16%)
		C2H2 Zn finger	139..159	CDD:275368	3/19 (16%)
		C2H2 Zn finger	195..215	CDD:275368	4/22 (18%)
		C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/21 (24%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	10/19 (53%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		SFP1	<497..576	CDD:227516	2/4 (50%)
		C2H2 Zn finger	503..523	CDD:275368
		C2H2 Zn finger	531..551	CDD:275368
		C2H2 Zn finger	559..579	CDD:275368
		SFP1	<582..661	CDD:227516
		C2H2 Zn finger	587..607	CDD:275368
		COG5048	629..>727	CDD:227381
		C2H2 Zn finger	643..663	CDD:275368
		C2H2 Zn finger	671..691	CDD:275368
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	727..747	CDD:275368