Protein Alignment CG1571 and DNAI1

DIOPT Version :10

• Sequence 1: NP_572435.1
• Gene: CG1571 / 31725
• FlyBaseID: FBgn0029993
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_001268357.1
• Gene: DNAI1 / 27019
• HGNCID: 2954
• Length: 703
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 122/656 - (18%)
• Similarity: 226/656 - (34%)
• Gaps: 198/656 - (30%)

  Fly    16 GRQCRFQDRNELMVSVHPSGRQRLKYIM--------ANPSEKSTQLSRQ-------MALTVMETE 65
            ||:..::|  ||:...:...::.:|.|.        ..|.|..|:...|       .|..|.|.|
Human   118 GRRQHYRD--ELVAVSYQGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEE 180

  Fly    66 NVTLDQHGMYHYEGGWPKE------VNFNDE---------------------------------- 90
            .:|..|          |||      .||::.
Human   181 LMTPKQ----------PKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIY 235

  Fly    91 ----EQTQRHRKKVERE------------------DSWGEQVLSMIRTTMSVAEQNNTLNIYQNF 133
                |:.::..|..|:|                  .|...|...:|:.:.:.......:|  ||.
Human   236 DAYVEELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVN--QNT 298

  Fly   134 FADLPPELGH--DIKMRFRARVANVFHDLWL----PARQL--RSIEWMPNNSRQFMTQYTNH-FA 189
            :.|:..:..:  |....:|.:|..:. .||.    .|::|  .::.|.|.....|...|.:: |.
Human   299 YDDIAQDFKYYDDAADEYRDQVGTLL-PLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFM 362

  Fly   190 KGERLRPVTDEPFGGTNGFYVWDVKNPLKPRITYDSKQQVSLAKICPKDENNMVGGTGLGQVCL- 253
            |..|            ....::.:|||..|...:.|..                     |.:||
Human   363 KQSR------------GMLLLYSLKNPSFPEYMFSSNS---------------------GVMCLD 394

  Fly   254 ----------WGTFKGGLPIRNCPLEVSHRE---TTSALCWVHS-------------KSNTEFYS 292
                      .|.:.|.:.|.|  |:..|.:   .:||....||             ..|..|:|
Human   395 IHVDHPYLVAVGHYDGNVAIYN--LKKPHSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFS 457

  Fly   293 GSLDGSIKYWDTRDLKM---PMQELLLEPEPQERQSRMDSHGV---TVLEFEYTIPVRFIIGSDM 351
            .|.||.|..|.....|:   .:.:|.:|....|....:..|.|   |..:|...|...|::|::.
Human   458 VSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEE 522

  Fly   352 GHVFVGNRKGMTP-METLLAHYQLFVGPVRSINRNPFFVKNFL-VTGDWRARIWSEEVKDSPSTM 414
            |.::..::...:. ::|..||..    .|.:::.||:..|.|: .:.||..:||...:| :|..:
Human   523 GKIYKCSKSYSSQFLDTYDAHNM----SVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIK-TPMFI 582

  Fly   415 YFRKNAQILCGAWSTGRCSLFVTGDINGVVDFWDLLLHH-----RKPIRSVDFKVAIADLVFRPE 474
            | ..|:.:...||:....::|.....:|....:||.::.     .:|:.:.  |..:..:.|...
Human   583 Y-DLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAK--KNRLTHVQFNLI 644

  Fly   475 GDLLAIGLKNGDTHIMTLDESMRQATGKEKALMAAMFEREIVRCKLLE-ARYDEVRLKRKTLQMA 538
            ..::.:|...|....:.|..::|:...::|.       :|:.:...:| |:.|      |.|.:.
Human   645 HPIIIVGDDRGHIISLKLSPNLRKMPKEKKG-------QEVQKGPAVEIAKLD------KLLNLV 696

  Fly   539 EEERVR 544
            .|.:::
Human   697 REVKIK 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1571	NP_572435.1	WD40	210..462	CDD:475233	61/291 (21%)
		WD40 repeat	229..269	CDD:293791	7/50 (14%)
		WD40 repeat	277..325	CDD:293791	16/63 (25%)
		WD40 repeat	332..369	CDD:293791	8/40 (20%)
		WD40 repeat	379..415	CDD:293791	11/36 (31%)
		WD40 repeat	422..447	CDD:293791	4/24 (17%)
DNAI1	NP_001268357.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..174		4/29 (14%)
		WD 1	324..374		11/62 (18%)
		WD40 repeat	339..385	CDD:293791	11/57 (19%)
		WD40	<357..615	CDD:475233	61/298 (20%)
		WD 2	379..417		9/60 (15%)
		WD40 repeat	391..428	CDD:293791	8/38 (21%)
		WD 3	426..469		12/42 (29%)
		WD40 repeat	439..496	CDD:293791	12/56 (21%)
		WD 4	478..530		11/51 (22%)
		WD40 repeat	504..541	CDD:293791	7/36 (19%)
		WD 5	535..574		12/42 (29%)
		WD40 repeat	547..584	CDD:293791	12/38 (32%)
		WD 6	578..616		7/38 (18%)
		WD40 repeat	589..616	CDD:293791	4/26 (15%)
		WD 7	622..662		5/41 (12%)