Protein Alignment: Upf2 and Upf2

• Sequence 1: NP_572434.1
• Gene: Upf2
• FlyBaseID: FBgn0029992
• Length: 1241
• Species: Drosophila melanogaster
• Sequence 2: NP_001074601.1
• Gene: Upf2
• MGIID: 2449307
• Length: 1269
• Species: Mus musculus
• Alignment Length: 1260
• Identity: 464/1261 (37%)
• Similarity: 697/1261 (55%)
• Gaps: 164/1261 (13%)

  Fly    42 DANADEDVDAAAAIALEAEEREELQQFISELREKIESKRQLRL--QNSTIELPGEEYFAKLDSNL 104
            :..|....:.|||   :.:|:||..|...|..|:.:.:::||.  ||:....|.|.:|::|||:|
Mouse   106 EEQAKRQQEEAAA---QLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSL 167

  Fly   105 KKNTAFVKKLKLFTATQLDGLLREISALNLSKYISEICAALVEAKLKMTDVPAVVTLASRLHCTY 169
            |||||||||||..|..|.|.|..:.:.|||||||:|..|::||||||::||.....|.|..|..|
Mouse   168 KKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKLSDVNCAAHLCSLFHQRY 232

  Fly   170 ADFDVHFLEAWQKALNIKATEKIGNPSKLRVDLRLFAELVSSGVIQMKPGLAQLGVVLVHLIALD 234
            :||....|:.|:|....:..||..|.:|||.|||..|||...|:...|.||:.:...|..:|..|
Mouse   233 SDFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINAD 297

  Fly   235 KDDHSNFSIILSFCRHCGEEYAGLVPQKMQQLATKYGVEVPKSDFLTADKQLNLRTMLKGYFKAL 299
            ::.|::.|:::|||||||::.|||||:|::..|.|:.:..|.|:.::.:||...:.:||.||.:|
Mouse   298 RESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSL 362

  Fly   300 CKHVLAEQAELMNMTKNIRRTMECKGEISTEKREKCELMQAGFDKLLASAQSLSELLGEPLPELA 364
            .||:..:..||.|..:..||.:..|||:|.::.::.|.....:.||||::|||::||.|.:|:|.
Mouse   363 TKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLP 427

  Fly   365 KES---EGCNPGTVIDNMLDSASFGVLD----PWGDEETRAFYTDLPDLRQFLP----------- 411
            ::.   |...||  || :......|..|    .|.||:.|.||.:|.||:.|:|
Mouse   428 QDKPTPEEHGPG--ID-IFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQ 489

  Fly   412 NFSAPKVDLETLEEPSELTEEAIDANLDAE---MDLDDPPSTTSDTTPENPIEEQPTTPVAAAED 473
            |..:.|.|.:..:||.:..|.:...:|:.|   ::::|      ||......:|        |||
Mouse   490 NKDSNKDDSKEAKEPKDNKEASSPDDLELELENLEIND------DTLELEGADE--------AED 540

  Fly   474 LKPQKMGNALMELGRQQQQQSQLNQNPIQIQNQMRQQFDGFLVNLFNCVNKELIDSAAIEFLLNF 538
            | .:|:      |..|:|:..:.:..     :.::...|.||..|.||||::|||.||::|.:|.
Mouse   541 L-TKKL------LDEQEQEDEEASTG-----SHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNM 593

  Fly   539 NTKHQRKKLTRTIFSVQRTRLDILPYLSRFVAIVHMCNTDVATDLAELLRKEFKWHIHKKNQLNI 603
            |||..||||.|.:|.|.|.|||:||:.:|.||.:|.|.:|||.||..:||.:|::|:.||:|:||
Mouse   594 NTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINI 658

  Fly   604 ETKLKIVRFIGELVKFGLFKKFDALGCLKMLLRDFQHHQIEMACAFVEVTGVYLYNCRDARLLMN 668
            |||.|.|||||||.||.:|.|.|.|.||||||.||.||.|||||..:|..|.:|:...::.|..:
Mouse   659 ETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTS 723

  Fly   669 VFLDQMLRLKTATAMDSRHAAQIESVYYLVKPPESSKREPMVRPAMHEYIRYLIFEELCKQNVDR 733
            |.|:||:|.|.|..:|:|:...:|:.||...||.:.|.....||.:.||:|.|::::|.|...::
Mouse   724 VLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEK 788

  Fly   734 CIKMLRRIDWQDPETNCYAIKCLSKAYLLRFQLIRCLADLVSGLSSYQPRAVTIVIDNVFEDIRA 798
            .::.:|::.|||.|...|.|.|:...:.:::..|.|:|:|::||..||......|:|.|.||||.
Mouse   789 VLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRL 853

  Fly   799 GLEIHSPRMAQRRIAMAKYLGEMYNYKLVESTNILNTLYSIISLGVSNDQNVVSPLDPPDSLFRL 863
            |:|::.|:..||||:.||:|||:|||::|||..|..||||..|.||:.|.: .|.||||:.|||:
Mouse   854 GMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGS-PSSLDPPEHLFRI 917

  Fly   864 KLACMLLDTCAPYFTSQATRKKLDYFLVFFQHYYWFKKSHPVFSKTENTSDLFPILMDHTYRDCL 928
            :|.|.:||||..||...::::|||.|||:||.|.|:|||..|::|...    |||.:|:...|.|
Mouse   918 RLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHP----FPIDIDYMISDTL 978

  Fly   929 LNVRPKLKIYKSLEQAKAAIDHLQEKLYPQLKTTNNAQDPSLGT----ISEISEIDEGG--TDED 987
            ..:|||:|:..|||::...:..|:.:...:|...|:.:.....|    :.|..|.:|||  |:|.
Mouse   979 ELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQ 1043

  Fly   988 SGSSNDQR--------ERQVSGQEQDQSN-DW-----TENEAEPP----------LPPLPPPEKS 1028
            ||:.::..        |.:..|:|:::.| |:     .|||.:..          |..:|    .
Mouse  1044 SGNESEVNEPEEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVP----C 1104

  Fly  1029 KEDLEFEQLYEKMTTDSYQERLKEPIKATAKDIPVPMMARLQKKSYDQITGAQTIGPGINNMSQI 1093
            .||.:|.|..:||..::.|:|..|.:|....|:.:|:..:                      ||:
Mouse  1105 VEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLK----------------------SQL 1147

  Fly  1094 SKSVPNQDGTPGSPGADSPDGNGKSGGGVGGSDVGAAGAAGASGATSVPFVLMVRGHKGGKQQFK 1158
            .|..|                   .|||.|.::          .|.::|||::.|  ||.|||||
Mouse  1148 RKGPP-------------------LGGGEGETE----------SADTMPFVMLTR--KGNKQQFK 1181

  Fly  1159 SFVAPSDSHLATNLKRQEQMIREEKEKVKRLTLNITERIEEEDYQESLMPPQHRNFTQSYYQKP- 1222
            ....|..|.||.|...|:|..:||:.::|:|||:|.||.|:|||||.|         ||..|:|
Mouse  1182 ILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEML---------QSLAQRPA 1237

  Fly  1223 -------NKHKFKHQKGAPDADLIF 1240
                   .:.:::|.||||:|||||
Mouse  1238 PANTNRERRPRYQHPKGAPNADLIF 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf2	NP_572434.1	MIF4G	104..300	CDD:214713	87/196 (44%)
		MIF4G	518..701	CDD:214713	96/183 (52%)
		MIF4G	716..934	CDD:280935	95/218 (44%)
		Upf2	980..1192	CDD:281974	62/238 (26%)
Upf2	NP_001074601.1	MIF4G	167..362	CDD:214713	86/195 (44%)
		DUF1451	357..>420	CDD:302977	24/63 (38%)
		MIF4G	569..756	CDD:214713	95/187 (51%)
		MIF4G	771..984	CDD:214713	92/213 (43%)
		Upf2	1082..1215	CDD:281974	27/143 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C325624227
eggNOG	1	0.900				E1_KOG2051
Hieranoid	1	1.000
Homologene	1	1.000				H6101
Inparanoid	1	1.050	753	1.000	Inparanoid score	I560
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0003759
OrthoInspector	1	1.000				T1085564
orthoMCL	1	0.900				OOG5_129338
Panther	1	1.100			LDO	PTHR12839
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R816
TreeFam	1	0.960
	13	12.790