DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf2 and Upf2

DIOPT Version :9

Sequence 1:	NP_572434.1	Gene:	Upf2 / 31724	FlyBaseID:	FBgn0029992	Length:	1241	Species:	Drosophila melanogaster
Sequence 2:	NP_001074601.1	Gene:	Upf2 / 326622	MGIID:	2449307	Length:	1269	Species:	Mus musculus

Alignment Length:	1260	Identity:	464/1260 - (36%)
Similarity:	697/1260 - (55%)	Gaps:	164/1260 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DANADEDVDAAAAIALEAEEREELQQFISELREKIESKRQLRL--QNSTIELPGEEYFAKLDSNL 104
            :..|....:.|||   :.:|:||..|...|..|:.:.:::||.  ||:....|.|.:|::|||:|
Mouse   106 EEQAKRQQEEAAA---QLKEKEESLQLHQEAWERHQLRKELRSKNQNAPDNRPEENFFSRLDSSL 167

  Fly   105 KKNTAFVKKLKLFTATQLDGLLREISALNLSKYISEICAALVEAKLKMTDVPAVVTLASRLHCTY 169
            |||||||||||..|..|.|.|..:.:.|||||||:|..|::||||||::||.....|.|..|..|
Mouse   168 KKNTAFVKKLKTITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKLSDVNCAAHLCSLFHQRY 232

  Fly   170 ADFDVHFLEAWQKALNIKATEKIGNPSKLRVDLRLFAELVSSGVIQMKPGLAQLGVVLVHLIALD 234
            :||....|:.|:|....:..||..|.:|||.|||..|||...|:...|.||:.:...|..:|..|
Mouse   233 SDFAPSLLQVWKKHFEARKEEKTPNITKLRTDLRFIAELTIVGIFTDKEGLSLIYEQLKSIINAD 297

  Fly   235 KDDHSNFSIILSFCRHCGEEYAGLVPQKMQQLATKYGVEVPKSDFLTADKQLNLRTMLKGYFKAL 299
            ::.|::.|:::|||||||::.|||||:|::..|.|:.:..|.|:.::.:||...:.:||.||.:|
Mouse   298 RESHTHVSVVISFCRHCGDDIAGLVPRKVKSAAEKFNLSFPPSEIISPEKQQPFQNLLKEYFTSL 362

  Fly   300 CKHVLAEQAELMNMTKNIRRTMECKGEISTEKREKCELMQAGFDKLLASAQSLSELLGEPLPELA 364
            .||:..:..||.|..:..||.:..|||:|.::.::.|.....:.||||::|||::||.|.:|:|.
Mouse   363 TKHLKRDHRELQNTERQNRRILHSKGELSEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLP 427

  Fly   365 KES---EGCNPGTVIDNMLDSASFGVLD----PWGDEETRAFYTDLPDLRQFLP----------- 411
            ::.   |...||  || :......|..|    .|.||:.|.||.:|.||:.|:|
Mouse   428 QDKPTPEEHGPG--ID-IFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSQ 489

  Fly   412 NFSAPKVDLETLEEPSELTEEAIDANLDAE---MDLDDPPSTTSDTTPENPIEEQPTTPVAAAED 473
            |..:.|.|.:..:||.:..|.:...:|:.|   ::::|      ||......:|        |||
Mouse   490 NKDSNKDDSKEAKEPKDNKEASSPDDLELELENLEIND------DTLELEGADE--------AED 540

  Fly   474 LKPQKMGNALMELGRQQQQQSQLNQNPIQIQNQMRQQFDGFLVNLFNCVNKELIDSAAIEFLLNF 538
            | .:|:      |..|:|:..:.:..     :.::...|.||..|.||||::|||.||::|.:|.
Mouse   541 L-TKKL------LDEQEQEDEEASTG-----SHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNM 593

  Fly   539 NTKHQRKKLTRTIFSVQRTRLDILPYLSRFVAIVHMCNTDVATDLAELLRKEFKWHIHKKNQLNI 603
            |||..||||.|.:|.|.|.|||:||:.:|.||.:|.|.:|||.||..:||.:|::|:.||:|:||
Mouse   594 NTKANRKKLVRALFIVPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINI 658

  Fly   604 ETKLKIVRFIGELVKFGLFKKFDALGCLKMLLRDFQHHQIEMACAFVEVTGVYLYNCRDARLLMN 668
            |||.|.|||||||.||.:|.|.|.|.||||||.||.||.|||||..:|..|.:|:...::.|..:
Mouse   659 ETKNKTVRFIGELTKFKMFTKNDTLHCLKMLLSDFSHHHIEMACTLLETCGRFLFRSPESHLRTS 723

  Fly   669 VFLDQMLRLKTATAMDSRHAAQIESVYYLVKPPESSKREPMVRPAMHEYIRYLIFEELCKQNVDR 733
            |.|:||:|.|.|..:|:|:...:|:.||...||.:.|.....||.:.||:|.|::::|.|...::
Mouse   724 VLLEQMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVRKKRPPLQEYVRKLLYKDLSKVTTEK 788

  Fly   734 CIKMLRRIDWQDPETNCYAIKCLSKAYLLRFQLIRCLADLVSGLSSYQPRAVTIVIDNVFEDIRA 798
            .::.:|::.|||.|...|.|.|:...:.:::..|.|:|:|::||..||......|:|.|.||||.
Mouse   789 VLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVDGVLEDIRL 853

  Fly   799 GLEIHSPRMAQRRIAMAKYLGEMYNYKLVESTNILNTLYSIISLGVSNDQNVVSPLDPPDSLFRL 863
            |:|::.|:..||||:.||:|||:|||::|||..|..||||..|.||:.|.: .|.||||:.|||:
Mouse   854 GMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGS-PSSLDPPEHLFRI 917

  Fly   864 KLACMLLDTCAPYFTSQATRKKLDYFLVFFQHYYWFKKSHPVFSKTENTSDLFPILMDHTYRDCL 928
            :|.|.:||||..||...::::|||.|||:||.|.|:|||..|::|...    |||.:|:...|.|
Mouse   918 RLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVWTKDHP----FPIDIDYMISDTL 978

  Fly   929 LNVRPKLKIYKSLEQAKAAIDHLQEKLYPQLKTTNNAQDPSLGT----ISEISEIDEGG--TDED 987
            ..:|||:|:..|||::...:..|:.:...:|...|:.:.....|    :.|..|.:|||  |:|.
Mouse   979 ELLRPKIKLCNSLEESIRQVQDLEREFLIKLGLVNDKESKDSMTEGENLEEDEEEEEGGAETEEQ 1043

  Fly   988 SGSSNDQR--------ERQVSGQEQDQSN-DW-----TENEAEPP----------LPPLPPPEKS 1028
            ||:.::..        |.:..|:|:::.| |:     .|||.:..          |..:|    .
Mouse  1044 SGNESEVNEPEEEEGSEEEEEGEEEEEENTDYLTDSNKENETDEENAEVMIKGGGLKHVP----C 1104

  Fly  1029 KEDLEFEQLYEKMTTDSYQERLKEPIKATAKDIPVPMMARLQKKSYDQITGAQTIGPGINNMSQI 1093
            .||.:|.|..:||..::.|:|..|.:|....|:.:|:..:                      ||:
Mouse  1105 VEDEDFIQALDKMMLENLQQRSGESVKVHQLDVAIPLHLK----------------------SQL 1147

  Fly  1094 SKSVPNQDGTPGSPGADSPDGNGKSGGGVGGSDVGAAGAAGASGATSVPFVLMVRGHKGGKQQFK 1158
            .|..|                   .|||.|.::          .|.::|||::.|  ||.|||||
Mouse  1148 RKGPP-------------------LGGGEGETE----------SADTMPFVMLTR--KGNKQQFK 1181

  Fly  1159 SFVAPSDSHLATNLKRQEQMIREEKEKVKRLTLNITERIEEEDYQESLMPPQHRNFTQSYYQKP- 1222
            ....|..|.||.|...|:|..:||:.::|:|||:|.||.|:|||||.|         ||..|:|
Mouse  1182 ILNVPMSSQLAANHWNQQQAEQEERMRMKKLTLDINERQEQEDYQEML---------QSLAQRPA 1237

  Fly  1223 -------NKHKFKHQKGAPDADLIF 1240
                   .:.:::|.||||:|||||
Mouse  1238 PANTNRERRPRYQHPKGAPNADLIF 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf2	NP_572434.1	MIF4G	104..300	CDD:214713	86/195 (44%)
		MIF4G	518..701	CDD:214713	95/182 (52%)
		MIF4G	716..934	CDD:280935	94/217 (43%)
		Upf2	980..1192	CDD:281974	61/237 (26%)
Upf2	NP_001074601.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..125		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..162		6/20 (30%)
		MIF4G	167..362	CDD:214713	86/194 (44%)
		DUF1451	357..>420	CDD:418628	23/62 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..444		8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..518		6/33 (18%)
		MIF4G	569..756	CDD:214713	95/186 (51%)
		MIF4G	774..984	CDD:397130	92/209 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1090		22/102 (22%)
		Upf2	1091..1215	CDD:397938	25/123 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1218..1269		26/50 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848270
Domainoid	1	1.000	202	1.000	Domainoid score	I2988
eggNOG	1	0.900	-	-		E1_KOG2051
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6101
Inparanoid	1	1.050	753	1.000	Inparanoid score	I564
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55567
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005166
OrthoInspector	1	1.000	-	-		oto92158
orthoMCL	1	0.900	-	-		OOG6_103377
Panther	1	1.100	-	-	LDO	PTHR12839
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R816
SonicParanoid	1	1.000	-	-		X3685
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790