Protein Alignment fs(1)h and BDF2

DIOPT Version :10

• Sequence 1: NP_001259321.1
• Gene: fs(1)h / 31722
• FlyBaseID: FBgn0004656
• Length: 2046
• Species: Drosophila melanogaster
• Sequence 2: NP_010213.1
• Gene: BDF2 / 851488
• SGDID: S000002228
• Length: 638
• Species: Saccharomyces cerevisiae
• Alignment Length: 716
• Identity: 140/716 - (19%)
• Similarity: 230/716 - (32%)
• Gaps: 322/716 - (44%)

  Fly     2 SSSEPPPRYEPPVEP-VNGIVQPPVIPPAERPGRNTNQLQYLIKTVMKVIWKHHFSWPFQQPVDA 65
            |..|.|...|...|| :...::...:||        :|.:||:.:: |...:...:.||.:|||.
Yeast   109 SFPEHPLGLERETEPALEAEMEAEELPP--------HQSKYLLSSI-KATKRLKDARPFLKPVDP 164

  Fly    66 KKLNLPDYHKIIKQPMDMGTIKKRLENNYYWSAKETIQDFNTMFNNCYVYNKPGEDVVVMAQTLE 130
            ..||:|.|...::.|||:..|:.:|:.|.|.|.::...||.||.:||..:|.|...:..||:.::
Yeast   165 IALNIPHYFNYVQTPMDLSLIETKLQGNVYHSVEQVTSDFKTMVDNCLNFNGPESSISSMAKRIQ 229

  Fly   131 KVFLQKIESMPKEELELEPV--TAKGGKKKQRAPATPKSSSGGAGASTGSGTSSAAVTSGPGSGS 193
            |.|.:|:.:||...|....:  |::..||.:...:
Yeast   230 KYFEKKLSAMPPRVLPASALKKTSRNRKKNEDMDS------------------------------ 264

  Fly   194 TKVSVAASSAQQSGLQGATGAGGGSSSTPGTQPGSGAGGAIAARPVSAMGGTVSSTAGGAPSIPP 258
                                                                             
Yeast   265 ----------------------------------------------------------------- 264

  Fly   259 ISTMPPHTVPGSTNTTTTAMAGGVGGPGAAGANPNAAALMASLLNAGQTGAYPGAPGQTAVNSSS 323
                 |..:..|.:||..                          |.|:
Yeast   265 -----PLVIRRSVSTTND--------------------------NIGE----------------- 281

  Fly   324 LLDGSTAAVAAAAAAAAAAAAAAGGAAGAAGGAGTIPAVAVNAANAVQAYVNAGVSVGVDAVIPP 388
                                  :|...|.:||.   |...::                     ||
Yeast   282 ----------------------SGNREGVSGGR---PKRTIH---------------------PP 300

  Fly   389 QQPAKIKKGVKRKADTTTPTANAFESPYTQMDSKSAKIATRRESNRQVIGKKGSGYNMSPLGVSG 453
                                             ||..:....|:
Yeast   301 ---------------------------------KSKDLFDIYEN--------------------- 311

  Fly   454 VPGLGGLVAGGVAGVAVAKNKEK-LSDALKSCNEILKELFSKKHSGYAWPFYKPVDAEMLGLHDY 517
                             :|.|.| |....::|.:|||.|.|||:|...:||.:|||...|.|.:|
Yeast   312 -----------------SKPKSKTLQKKFRTCLKILKVLMSKKNSDINFPFLQPVDPIALNLPNY 359

  Fly   518 HDIIKKPMDLGTVKRKMDNREYKSAPEFAADVRLIFTNCYKYNPPDHDVVAMGRKLQDVFEMRYA 582
            .|::|.||||||:...:.|.:||:..:|..|:.|:|.||:::||..::|.:||:||:::|...:
Yeast   360 FDVVKNPMDLGTISNNLMNWKYKTIDQFVDDLNLVFYNCFQFNPEGNEVHSMGKKLKELFNFHW- 423

  Fly   583 NIPDEPVANAAHHHGHGHGHGHGHGHGHGHGHGHGHGHGYGGSSSLKHD--ASDSSSEDSSDTEN 645
             :.::.:.|...                             ..|.|:.|  :|..||:|..|.|:
Yeast   424 -LENQDILNEIE-----------------------------TDSDLEEDNYSSSYSSDDEYDDED 458

  Fly   646 ESNSDEERSA------RLKMLESKLLGL-QEEIRKLSEEASAKKKAKKKLKEK---------KKS 694
            .:.:|....|      :||.:|.:|..| ::|:.|||:|...|...|..|:.|         |||
Yeast   459 INENDITNPAIQYLEQKLKKMEVELQQLKRQELSKLSKERKRKHLGKTLLRRKAMKHSVDDLKKS 523

  Fly   695 I 695
            |
Yeast   524 I 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)h	NP_001259321.1	Bromo_Brdt_I_like	34..140	CDD:99929	34/105 (32%)
		COG5076	387..>593	CDD:227408	52/206 (25%)
		Bromo_Brdt_II_like	481..581	CDD:99930	42/99 (42%)
		BET	951..1015	CDD:435704
		BRD4_CDT	<2026..2046	CDD:465349
BDF2	NP_010213.1	COG5076	55..378	CDD:227408	93/537 (17%)
		Bromodomain	<344..419	CDD:445827	32/74 (43%)
		Lebercilin	<472..>537	CDD:464776	18/53 (34%)
		BET	521..576	CDD:435704	4/4 (100%)