Protein Alignment Ubr3 and Ubr3

DIOPT Version :10

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: XP_038960775.1
• Gene: Ubr3 / 311115
• RGDID: 1565257
• Length: 1901
• Species: Rattus norvegicus
• Alignment Length: 2284
• Identity: 737/2284 - (32%)
• Similarity: 1078/2284 - (47%)
• Gaps: 556/2284 - (24%)

  Fly    98 SSVAAAAAPPPPPPRT---GPTTTTSSGTAAESGAASALSDD-AGAKPSFFFGASSFSLRSRKEV 158
            ::.||...|.||.|..   || |...:.|||...||.:..|: |||:
  Rat     4 AAAAAVGGPQPPQPEVSAQGP-TLDKAATAAHLKAALSRPDNRAGAE------------------ 49

  Fly   159 AALINTECCRGSPTPDLDSIMDTLFNPGTPIDNL-----------------DNIEWIRWLIAGGR 206
                           :|.::::.:.|...|:...                 |.:||.:.|:|||.
  Rat    50 ---------------ELQALLERVLNAERPLARAAGGEEAAGGGSPGEAEEDALEWCKCLLAGGG 99

  Fly   207 TPQEFVKIVRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAG 271
            ...||...||:||..|.|||||..:.|||||||||||||||:|.:||.:|:||.||||||.||||
  Rat   100 GYDEFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAG 164

  Fly   272 GACDCGDTSVMKAEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFRE-----HSDT 331
            |||||||::||:..|||..|.|.:..|...||.:||.::|.::|:.:|.|:|:.||     .:||
  Rat   165 GACDCGDSNVMRESGFCRRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADT 229

  Fly   332 PLE------VQAITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVY----AFFMEAPCQDTR 386
            |.|      :|.:     |...:.|.||...|..||.|:|:.|.|.:.|    |...|..|
  Rat   230 PSEKDLNKVLQLL-----EPQISFLEDLTKTGGAMRAVLTQVLTNQQSYKDLTAGLGENTC---- 285

  Fly   387 NGRFLKANREKYEDAVN----RFPN-------PEPPDEYRDLPALG------------------- 421
                .|.:.|||..|:.    .:|.       .||......|.|.|
  Rat   286 ----AKKSHEKYLIALKSSGLTYPEDKLVYGIQEPSAGTSTLAAQGFAGATGTLGQIDSSDEEDQ 346

  Fly   422 ------------------------DKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEH 462
                                    |.|.|.:.|||.:|||.|:||||.:|.|||||||||:||..
  Rat   347 DGSQGLGKRKRVKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVA 411

  Fly   463 LTRTFVMHYSRIPSVLEMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMS 527
            .|:|||.||:.|...|:.|.:.||:|||:||:||||||||.||.::..|..||.:|:..|..||.
  Rat   412 FTKTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMME 476

  Fly   528 KILIQNTLHDPNKNFHFVIDCTRQVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNLIDMWFQFL 592
            ..||::.|.|...:.|.|::|...::|::.||||||||.|:|||:|||..||.|..|:..|..|:
  Rat   477 SCLIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTWMNFV 541

  Fly   593 QMLQGMNVNVRETASHVEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTT 657
            ...||||:|.||...|||||..:|||||:.||||.|.|||.::||.:........:.::.||:..
  Rat   542 SFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTRNVVRYCLEA 606

  Fly   658 LHEWLDSIYFMEARLSMEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIH 722
            |.:|.|:|.|::.    ....|.:||.|||||.|.|:.:||....:.|:.:||.:..|:. ||||
  Rat   607 LQDWFDAINFVDE----PAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSLLPDQEMLMK-LMIH 666

  Fly   723 PLRVQSFFYEILAGKWVRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIE 787
            ||::|:...||.:..|||||||||||||||:|::|||||.|.|::.||:||:.|...:|:.:..|
  Rat   667 PLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFE 731

  Fly   788 LFDVGQWLETAPLKQPQKAE---QSSMLEGFLTFLATLVTSRTNLG--NDEATQCIIEISALLAT 847
            .|.|...|..|........:   :.|||||.||||..|::.|.:||  :||..:.  |:.|.|..
  Rat   732 RFKVVDLLTMASQHHNMVLDVEHERSMLEGALTFLVILLSLRLHLGMSDDEILRA--EMVAQLCM 794

  Fly   848 ENKTHSQLLELMPE----RSGNV-HTKNFETFLKKLSVYKAP---SSGSENLEQGLFTPIDEVWE 904
            .::|||.||:|:||    :||.: .:.:||:.|..::.:|||   ..||  ::||::||..|||:
  Rat   795 NDRTHSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFKAPVFEPGGS--MQQGMYTPKAEVWD 857

  Fly   905 KHYDPLHVLLRAVHRRDFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILN 969
            :.:||:.|:||.|:|||.||::||:|.::|...|.  |||.|||::...:|  ..|:....::|:
  Rat   858 QEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKF--SGNPWPPYKKRTSL--HPSYKGLMRLLH 918

  Fly   970 SRIFHSTILSIFFRAV--HTRDVSEHLLALAVFLLEIAVETS------DDVGSGTGDRAPPALAA 1026
            .:..|..:.::.::.:  | :::|||:|.:.::|:|:.:|.|      ::|..|..:|.
  Rat   919 CKTLHIVLFTLLYKILMDH-QNLSEHVLCMVLYLIELGLEDSAEDDSEEEVSMGGPERC------ 976

  Fly  1027 VVESSSGPGYHGYGTGRHEPPKLFHCYPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSD 1091
                             |:     ..:|..||..|:||.:..|  :.|.|
  Rat   977 -----------------HD-----SWFPGSNLVSNMRHFINYV--RVRVP--------------- 1002

  Fly  1092 LDFEVEADPEQSMRMIGQGDPEGDEATGGAGLGMGAHSRR-------NVSQALVPMRVPGMEVAL 1149
                 |..||.....:.        :|...|||...:|||       |...|.|
  Rat  1003 -----ETAPELKRDSLA--------STSSDGLGSLQNSRRPKVLQRENSGTAQV----------- 1043

  Fly  1150 PPDLSVVAETGVVIRQDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLL 1214
               .|:|||     |:...::.:.|..:.|
  Rat  1044 ---FSLVAE-----RRKKFQEIINRNNSEA----------------------------------- 1065

  Fly  1215 AETNNMGAIAGGAGGGANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPS 1279
                                        |::..|.||:                         ..
  Rat  1066 ----------------------------NQVVRPKTPS-------------------------KW 1077

  Fly  1280 NAMGAGGSFTSGVSGSGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSG 1344
            :|.|:....|:.:                                |.:.|||||||:|||.:|||
  Rat  1078 SAPGSAPQLTTAI--------------------------------LEIKESILSLLIKLHHKLSG 1110

  Fly  1345 TLDSFS---LSDGEDQSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGD 1406
            ..:|:.   |.|.|                           .|.:....|.::          ||
  Rat  1111 KQNSYYPPWLDDIE---------------------------VLIQPEIPKYSH----------GD 1138

  Fly  1407 GPFFIGNLLRKIAKQDEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQ 1471
            |...:..:|.|.|.|.....:.|::|..::.|....|:.....::..:|||||:||||||||::.
  Rat  1139 GITAVERILLKAAVQSRMNKRIIEEICRKVTPPVPPKKITTAEKKTLDKEERRQKARERQQKLLA 1203

  Fly  1472 DFANKQKLFMQSAAASSSGMGYGPEDEDDEELYEEQPREKE--YDCIICNCTTPSTESNPIGLVV 1534
            :||::||.||::|....|     ||::...|:...:|:..|  |||:||..:.||:|..|.||||
  Rat  1204 EFASRQKSFMETAMDVDS-----PENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVV 1263

  Fly  1535 LVESSGIVGHRRRIAERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYD 1599
            |:::|.::|..|...|...|||.  :|.::......||..:.|..||...|.|.|..|:.::.::
  Rat  1264 LLQASSVLGQCRDNVEPKKLPIT--EEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWE 1326

  Fly  1600 NGVHVQSCGHHVHLSCLEAYLKTLYTTQRQPVQ----DRGEFYCPVCRQLSNSVLPLSPQLDRPT 1660
            .||:||:|||.:|:.|.::|:::|  ...|.:|    |:|||.||:|||.:|||||..|..:...
  Rat  1327 GGVYVQTCGHTLHIDCHKSYMESL--RNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVEN 1389

  Fly  1661 HL-VRSGNQPFERLVADLTDLIKENE-----------TIPQPTKLTEAMGHAMEVMTNIAQRKVK 1713
            :| .|..|:..:       |||||.|           :|...|.|::.|...|:.:.|..|:|.:
  Rat  1390 NLWQRPSNKSTQ-------DLIKEVEELQGRPGAFPVSISSETNLSKEMESVMKDIKNTTQKKYR 1447

  Fly  1714 CSSITFRKL---FIFVTSIARTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHVRVLV 1775
            ..|.|....   |:|:.|:||||||.|:|.||||||:..|:. ..||.|:..|.|||::|:|:..
  Rat  1448 DYSKTPGSPDNDFLFMYSVARTNLELELIHRGGSLCSGGAST-AGKRSCLNQLFHVLALHMRLYT 1511

  Fly  1776 EWPLWSSWASLAGL------PVTATEPLPAHCLELIPSILADPIALLLKFILLAPLQLDQDYFTC 1834
            ....::.|..|..|      .|.:.:..|.     :|.:..|..:|||..||:.|..|.:::|||
  Rat  1512 IDSEYNPWKKLTHLVEDMNSQVGSEDQQPE-----VPVLYHDVTSLLLIQILMMPQPLQKEHFTC 1571

  Fly  1835 MVKVMYNLLYYQIVVQLCVTLTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQ 1899
            :|||::.|||.|.:..|.|..|:                .|.||               .:..|.
  Rat  1572 IVKVLFTLLYTQALAALSVKGTE----------------EDRSA---------------WKHLGA 1605

  Fly  1900 QQQSSSQLGKA----MALVLSQTNDLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASS 1960
            .::.:....|:    :..|:|:.                        |........||...|..|
  Rat  1606 LKKDTCDAEKSYEVLLGFVISEL------------------------SKGKLYCEEGAQECTMVS 1646

  Fly  1961 ATTIEVNLKSMELQLQALCLPFLRVAALLRQHLYRHEMPEISAPGLEFVRLVYYLELV-----TD 2020
              .|..:.:|||..:|..||||||:::||:.||:..::|...... ||..|...|.|:     ||
  Rat  1647 --PIAWSPESMERYIQDFCLPFLRISSLLQHHLFGEDLPSCQEEE-EFSVLASCLGLLPTFYQTD 1708

  Fly  2021 -------SMDWDCFNASKGLCFIPGTETTLPQFWCQQLMEVRPPADTVRE--LVLINQHSLWQQP 2076
                   .:||            |.....:...||   .|:|...:...|  ..|:.|.|.|:.|
  Rat  1709 HPFISASCLDW------------PVAAFDIITQWC---FEIRSFTERHAEQGKALLIQESRWKLP 1758

  Fly  2077 RLLELPREYERLFTYYHERPCLNCYKVPKESSICLLCGTIVCLKQNCCAENDCCEAVRHTLSCGG 2141
            .||:||..|..:|.|||.:.|..|.||||:.::||:||..||||..||.:...||.|.|:.:||.
  Rat  1759 HLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGAFVCLKGLCCKQQSYCECVLHSQNCGA 1823

  Fly  2142 GIGIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEEDRDLKRGKPLYLSKDRFNLLESQWLSHKFA 2206
            |.||||::.::.||:|||.|.|||||:|||...||||||:||||||:.::|:.:||.||:||.|.
  Rat  1824 GTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICEERYRVLEQQWVSHTFD 1888

  Fly  2207 HTKHTWVFH 2215
            |....|..|
  Rat  1889 HINKRWGPH 1897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	UBR-box_UBR3	224..292	CDD:439071	48/67 (72%)
		FliJ	<1410..1477	CDD:426581	23/66 (35%)
		RING-H2_UBR3	1601..1651	CDD:438146	25/53 (47%)
		PRT6_C	1722..2202	CDD:465944	169/506 (33%)
Ubr3	XP_038960775.1	UBR-box_UBR3	117..185	CDD:439071	48/67 (72%)
		RING-H2_UBR3	1328..1380	CDD:438146	17/51 (33%)
		PRT6_C	1438..1884	CDD:465944	139/474 (29%)