DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr3 and ubr3

DIOPT Version :9

Sequence 1:	NP_001259317.1	Gene:	Ubr3 / 31713	FlyBaseID:	FBgn0260970	Length:	2236	Species:	Drosophila melanogaster
Sequence 2:	XP_012826536.1	Gene:	ubr3 / 100498471	XenbaseID:	XB-GENE-1219144	Length:	1866	Species:	Xenopus tropicalis

Alignment Length:	2183	Identity:	710/2183 - (32%)
Similarity:	1054/2183 - (48%)	Gaps:	450/2183 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 RSRKEVAALINTECCRGSPTPDLD---SIMDTLFNPGTPIDNLDNIEWIRWLIAGGRTPQEFVKI 214
            |.::..|||:.::..|...:|.|:   .::|.:...|.|..  :.:||.:.|:|||...::|.:.
Frog    10 RDKEATAALLKSKLSRPDQSPGLERLNGLLDRVLCVGGPAG--EALEWCKCLLAGGDKFEDFCQA 72

  Fly   215 VRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDT 279
            ||||||...|||||..:.|||||||||||||||:|.:||.:|.|..||||||.|||||||||||:
Frog    73 VRSYDNATLCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGEHAGHDFNMFRSQAGGACDCGDS 137

  Fly   280 SVMKAEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFREHSDTP-------LEVQA 337
            :||:..|||..|.:........||.:||.::|.::|:.:|.|:|:.|:....|       .::|.
Frog   138 NVMRESGFCKRHRVKLSSCVPSVPQDLLVMSELVIPRFIFYLIQYLRDGYSEPGAEASPEKDLQK 202

  Fly   338 ITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNGRFLKANREKY---- 398
             |....:...:.|.||..||..||.|:|:.|.|.::|......|.:.|     ...:.|||
Frog   203 -TLQMLDPQISFLEDLTKMGGAMRSVLTQVLTNQQLYKDLSSGPGEST-----CSKSHEKYLIAL 261

  Fly   399 --------EDAVNRFPNPEPP------------------------DEYRD--------------- 416
                    |:.|:.....:.|                        :|.:|
Frog   262 KESGLSIPEENVSSGAQEQSPGTSTLAVKEVAGAEGAQGQLESSDEEDQDGRQCVGKRKRVKLSS 326

  Fly   417 ---LPALGDKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLTRTFVMHYSRIPSVL 478
               ..::.|.|.|...|||.:|||.|:||||.:|.||||||||||||...|:|||.||:.|...|
Frog   327 NTKDQSIMDMLKHKCFLEELLFWTIKYEFPQKMVTFLLNMLPDQDYKIAFTKTFVQHYAFIMKTL 391

  Fly   479 EMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKILIQNTLHDPNKNFH 543
            :.|.:.||:|||:||:||||||||.||.::..|..||.:|:..|..||...||::.|.|...:.|
Frog   392 KKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESCLIKSELQDEENSLH 456

  Fly   544 FVIDCTRQVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRETASH 608
            .|::|...::|::.||||||||.|:|||:|||..||.|..|:..|..|:...||||:|.||...|
Frog   457 VVVNCGEALLKNNTYWPLVSDFINILSHQSVAKKFLEDHGLLVTWMNFVSFFQGMNLNKRELTEH 521

  Fly   609 VEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHEWLDSIYFMEARLS 673
            ||||..:|||||:.||||.|.|||.::||.:........:.::.||:..|.:|.|:|.|::.
Frog   522 VEFESQTYYAAFAAELEACAQPMWGLLSHCKVPDTQEYTRNVVRYCLEALQDWFDAINFVDE--- 583

  Fly   674 MEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPLRVQSFFYEILAGKW 738
             ....|.:||.|||||.|.|:.:|:....|.|:.:||.:..|:. ||:|||.:|:...||.:..|
Frog   584 -PAPNQVTFHLPLHRYYAMFLSKAIKCQEIDLDSILPDQEMLMK-LMVHPLLIQASLSEIHSNMW 646

  Fly   739 VRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLETAPLKQP 803
            ||||||||||||||:|::|||||.|.|::.||:||:.|...:|:.:..|.|.|...|..|...|.
Frog   647 VRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASKLDPDYFISSVFERFKVVDLLTMASQHQN 711

  Fly   804 QKAE---QSSMLEGFLTFLATLVTSRTNLG--NDEATQCIIEISALLATENKTHSQLLELMPE-- 861
            ...:   :.|||||.||||..|::.|.:||  :||..:.  |:.:.|...::|||.||:|:||
Frog   712 TVLDADHERSMLEGALTFLVILLSLRLHLGMTDDEILRA--EMISQLCMNDRTHSSLLDLIPESP 774

  Fly   862 --RSGNV-HTKNFETFLKKLSVYKAP---SSGSENLEQGLFTPIDEVWEKHYDPLHVLLRAVHRR 920
              :||.: .:.:||:.|..::.:|||   ..||  ::||::||..::|::.:||:.|:||.|:||
Frog   775 NPKSGIMPGSCSFESVLSAVADFKAPVFEPGGS--MQQGMYTPKGDIWDQEFDPVMVILRTVYRR 837

  Fly   921 DFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHSTILSIFFRAV 985
            |.||::||:|.::|...:.  |||.|||::  ...|...|:....::|:.:..|..:.::.::.:
Frog   838 DVQSAMDRYTAFLKQSGRF--SGNPWPPYK--KRSPLHHSYKGLMRLLHCKTLHIVLFTLLYKIL 898

  Fly   986 --HTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGRHEPPK 1048
              | :::|||:|.:.::|:|:.:|.|            |...:..|:.:||.
Frog   899 MDH-QNMSEHVLCMVLYLIELGLENS------------PEDESCEENFAGPD------------- 937

  Fly  1049 LFHC----YPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADPEQSMRMIGQ 1109
              .|    :|..||.||:||.:..|  :.|.|                    |..||.      :
Frog   938 --RCHDSWFPGSNLLCNMRHFINYV--RVRVP--------------------ETAPEV------R 972

  Fly  1110 GDPEGDEATGGAGLGMGAH-----SRRNVSQALVPMRVPGMEVALPPDLSVVAE-----TGVVIR 1164
            .:|....:|.|......|.     .|.|...|.|              .|:|||     ..::.|
Frog   973 REPPASTSTDGPSSAQNARRPSLLQRENSGTAQV--------------FSLVAERRKKFQEIINR 1023

  Fly  1165 QDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGG 1229
            .:|..:.::|..:.|:..:.|.|
Frog  1024 NNSEANQVVRPKSSALKWTAPGA------------------------------------------ 1046

  Fly  1230 GANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSG 1294
                                ||..:.::
Frog  1047 --------------------TPQLTTVI------------------------------------- 1054

  Fly  1295 SGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSGTLDSFS---LSDGED 1356
                                          |.:.||:||||:|||.:|||..||:.   |.|.|.
Frog  1055 ------------------------------LEVKESMLSLLIKLHKKLSGKQDSYCPPWLDDPEC 1089

  Fly  1357 QSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQ 1421
            ....|   :...|:                                  |||...:..:|.|.|.|
Frog  1090 LVQPD---LPGYCH----------------------------------GDGVTAVERILLKAASQ 1117

  Fly  1422 DEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQKLFMQSAAA 1486
            .....||||:|..:..|....|::....::...|||||:||||||||::.:||::||.||::|..
Frog  1118 SRLNRQSIDEICKKAPPPVPPKKSSPADKKTLGKEERRQKARERQQKLLAEFASRQKSFMETAMD 1182

  Fly  1487 SSSGMGYGPEDEDDEEL--YEEQPREKEYDCIICNCTTPSTESNPIGLVVLVESSGIVGHRRRIA 1549
            ..|     ||.:...|:  .|:...|..|||:||..:.||||..|:|||||:::|.::||||:..
Frog  1183 VES-----PESDVAMEIAGAEQHVAEPIYDCVICGQSGPSTEDRPLGLVVLLQASSVLGHRRKST 1242

  Fly  1550 ERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYDNGVHVQSCGHHVHLS 1614
            |...||  ..:|.::......||..:.:..:|...|.|.|...|.::.::.||:||:|||.:|:.
Frog  1243 EPKKLP--TTEEEQIYQEGTCAAANDVKLAILQRYFKDSSCLQSVSVGWEGGVYVQTCGHTLHID 1305

  Fly  1615 CLEAYLKTLYTTQRQPVQ----DRGEFYCPVCRQLSNSVLPLSP--QLDRPT-HLVRSGNQPFER 1672
            |.::|:::|  ...|.:|    |:|||.||:|||.:|||||..|  ..:|.: |...:.::..:.
Frog  1306 CHKSYMESL--RNDQVLQGFSVDKGEFTCPLCRQFANSVLPCFPGDSTERGSWHSHAASSKSLQE 1368

  Fly  1673 LVADLTDLIKENETIP----QPTKLTEAMGHAMEVMTNIAQRKVKCSSITFRKL---FIFVTSIA 1730
            |:.::.||.::..|.|    ..|.|::.|...|:.:.:..|:|....|.|....   |:|:.|:|
Frog  1369 LIKEVEDLQEQLGTFPVSISSETNLSKEMEAVMKDIKSTTQKKYTDYSKTQGSPDNDFLFMYSVA 1433

  Fly  1731 RTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHVRVLVEWPLWSSWASLAGLPVTATE 1795
            |||||.|:|..|.:||:..|:. ..||.|:..|.|||::|:|:....|.::.|..|.  .|...:
Frog  1434 RTNLELELIHCGDNLCSGGASA-AGKRSCLNQLFHVLAMHMRLYSIDPEYNPWKKLT--QVIQKK 1495

  Fly  1796 PLPAHCL------ELIPSILADPIALLLKFILLAPLQLDQDYFTCMVKVMYNLLYYQIVVQLCVT 1854
            |    .|      |.:|.:..|..:|||..:|..|..|.:::|.|:|||:|.|||.|.:..|.|.
Frog  1496 P----SLGDDEEREEVPILFRDVTSLLLIQVLTMPQPLCKEHFVCIVKVLYTLLYTQAITSLSVK 1556

  Fly  1855 LTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQQQQSSSQLGKAMALVLSQTN 1919
            |                      .||.::.         .|.:|..::||...||....:|...
Frog  1557 L----------------------QAEDRKV---------WRESGSSKKSSYSSGKPWEALLGFV- 1589

  Fly  1920 DLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATTIEVNLKSMELQLQALCLPFLR 1984
                        .|..:..|......|.|.|.....|....|         :|..||..||||||
Frog  1590 ------------ISELSRGSLYQDEETDSINMSDFTAWYEDA---------IEHYLQQFCLPFLR 1633

  Fly  1985 VAALLRQHLYRHEMPEISAPGLEFVRLVYYLELVTDSMDWDCFNASKGLCFIPGTETTLPQFWCQ 2049
            :.:.|:.||:..::|...... ||..|...|.|:....:......|..|...|.:...|...||.
Frog  1634 ITSFLQHHLFGLDLPSCQEED-EFTVLSNCLGLLPSFSEASHQFVSASLLDWPVSAFDLISQWCS 1697

  Fly  2050 Q--LMEVRPPADTVRELVLINQHSLWQQPRLLELPREYERLFTYYHERPCLNCYKVPKESSICLL 2112
            :  |...:.| |...  ||:.|.:.|..||||:||..|..:|.|||.:.|..|.||||:.::||:
Frog  1698 EVNLFSDKHP-DQAN--VLLIQDTKWDLPRLLQLPENYNTIFQYYHRKCCSVCTKVPKDPALCLV 1759

  Fly  2113 CGTIVCLKQNCCAENDCCEAVRHTLSCGGGIGIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEED 2177
            |||.||||..||.:...||.|.|:.:||.|.||||::.::.||:|||.|.|||||:|||...|||
Frog  1760 CGTFVCLKGLCCKQQSYCECVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEED 1824

  Fly  2178 RDLKRGKPLYLSKDRFNLLESQWLSHKFAHTKHTWVFH 2215
            |||:||||||:.|:|:::||.||:||.|.|....|..|
Frog  1825 RDLRRGKPLYICKERYSMLEQQWVSHTFDHINKRWGPH 1862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	zf-UBR	224..291	CDD:280386	47/66 (71%)
Ubr3	NP_001259317.1	FliJ	<1410..1477	CDD:280262	26/66 (39%)
ubr3	XP_012826536.1	zf-UBR	81..149	CDD:366980	47/67 (70%)
		RING-H2_UBR3	1206..1344	CDD:319397	56/141 (40%)
		RING-H2 finger (C3H2C3-type)	1208..1335	CDD:319397	48/130 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	956	1.000	Domainoid score	I39
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H52092
Inparanoid	1	1.050	1101	1.000	Inparanoid score	I239
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0005748
OrthoInspector	1	1.000	-	-		oto102727
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060