Protein Alignment Ubr3 and ubr3

DIOPT Version :10

• Sequence 1: NP_001259317.1
• Gene: Ubr3 / 31713
• FlyBaseID: FBgn0260970
• Length: 2236
• Species: Drosophila melanogaster
• Sequence 2: XP_012826536.1
• Gene: ubr3 / 100498471
• XenbaseID: XB-GENE-1219144
• Length: 1866
• Species: Xenopus tropicalis
• Alignment Length: 2183
• Identity: 710/2183 - (32%)
• Similarity: 1054/2183 - (48%)
• Gaps: 450/2183 - (20%)

  Fly   153 RSRKEVAALINTECCRGSPTPDLD---SIMDTLFNPGTPIDNLDNIEWIRWLIAGGRTPQEFVKI 214
            |.::..|||:.::..|...:|.|:   .::|.:...|.|..  :.:||.:.|:|||...::|.:.
 Frog    10 RDKEATAALLKSKLSRPDQSPGLERLNGLLDRVLCVGGPAG--EALEWCKCLLAGGDKFEDFCQA 72

  Fly   215 VRSYDNHAKCGLVWVPHVVAYRCRTCGISPCMSICRDCFKKGNHTNHDFNMFLSQAGGACDCGDT 279
            ||||||...|||||..:.|||||||||||||||:|.:||.:|.|..||||||.|||||||||||:
 Frog    73 VRSYDNATLCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGEHAGHDFNMFRSQAGGACDCGDS 137

  Fly   280 SVMKAEGFCSDHGINNRVNRDPVPNNLLAVAEAIMPKLLFRLLQHFREHSDTP-------LEVQA 337
            :||:..|||..|.:........||.:||.::|.::|:.:|.|:|:.|:....|       .::|.
 Frog   138 NVMRESGFCKRHRVKLSSCVPSVPQDLLVMSELVIPRFIFYLIQYLRDGYSEPGAEASPEKDLQK 202

  Fly   338 ITSYSCEEFANMLIDLNNMGEIMRKVMTRTLINPEVYAFFMEAPCQDTRNGRFLKANREKY---- 398
             |....:...:.|.||..||..||.|:|:.|.|.::|......|.:.|     ...:.|||
 Frog   203 -TLQMLDPQISFLEDLTKMGGAMRSVLTQVLTNQQLYKDLSSGPGEST-----CSKSHEKYLIAL 261

  Fly   399 --------EDAVNRFPNPEPP------------------------DEYRD--------------- 416
                    |:.|:.....:.|                        :|.:|
 Frog   262 KESGLSIPEENVSSGAQEQSPGTSTLAVKEVAGAEGAQGQLESSDEEDQDGRQCVGKRKRVKLSS 326

  Fly   417 ---LPALGDKLVHTTLLEEFIFWTFKFEFPQTLVCFLLNMLPDQDYKEHLTRTFVMHYSRIPSVL 478
               ..::.|.|.|...|||.:|||.|:||||.:|.||||||||||||...|:|||.||:.|...|
 Frog   327 NTKDQSIMDMLKHKCFLEELLFWTIKYEFPQKMVTFLLNMLPDQDYKIAFTKTFVQHYAFIMKTL 391

  Fly   479 EMSRDPDTLSNRVVHMSVQLFSNESLALKMVNELSLLHVMIISLKLMMSKILIQNTLHDPNKNFH 543
            :.|.:.||:|||:||:||||||||.||.::..|..||.:|:..|..||...||::.|.|...:.|
 Frog   392 KKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESCLIKSELQDEENSLH 456

  Fly   544 FVIDCTRQVMKDHCYWPLVSDFNNVLSHESVALVFLRDDNLIDMWFQFLQMLQGMNVNVRETASH 608
            .|::|...::|::.||||||||.|:|||:|||..||.|..|:..|..|:...||||:|.||...|
 Frog   457 VVVNCGEALLKNNTYWPLVSDFINILSHQSVAKKFLEDHGLLVTWMNFVSFFQGMNLNKRELTEH 521

  Fly   609 VEFEPNSYYAAFSCELEASAYPMWSIISHLQDGTHAHLAKKIINYCVTTLHEWLDSIYFMEARLS 673
            ||||..:|||||:.||||.|.|||.::||.:........:.::.||:..|.:|.|:|.|::.
 Frog   522 VEFESQTYYAAFAAELEACAQPMWGLLSHCKVPDTQEYTRNVVRYCLEALQDWFDAINFVDE--- 583

  Fly   674 MEEMMQASFHFPLHRYLAAFVCQAVTKMGISLNDVLPSRPYLLPLLMIHPLRVQSFFYEILAGKW 738
             ....|.:||.|||||.|.|:.:|:....|.|:.:||.:..|:. ||:|||.:|:...||.:..|
 Frog   584 -PAPNQVTFHLPLHRYYAMFLSKAIKCQEIDLDSILPDQEMLMK-LMVHPLLIQASLSEIHSNMW 646

  Fly   739 VRNGLQIKGQAMTYIQANFCNSMADMDLFFLQICATNLPQYFFLQNTIELFDVGQWLETAPLKQP 803
            ||||||||||||||:|::|||||.|.|::.||:||:.|...:|:.:..|.|.|...|..|...|.
 Frog   647 VRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCASKLDPDYFISSVFERFKVVDLLTMASQHQN 711

  Fly   804 QKAE---QSSMLEGFLTFLATLVTSRTNLG--NDEATQCIIEISALLATENKTHSQLLELMPE-- 861
            ...:   :.|||||.||||..|::.|.:||  :||..:.  |:.:.|...::|||.||:|:||
 Frog   712 TVLDADHERSMLEGALTFLVILLSLRLHLGMTDDEILRA--EMISQLCMNDRTHSSLLDLIPESP 774

  Fly   862 --RSGNV-HTKNFETFLKKLSVYKAP---SSGSENLEQGLFTPIDEVWEKHYDPLHVLLRAVHRR 920
              :||.: .:.:||:.|..::.:|||   ..||  ::||::||..::|::.:||:.|:||.|:||
 Frog   775 NPKSGIMPGSCSFESVLSAVADFKAPVFEPGGS--MQQGMYTPKGDIWDQEFDPVMVILRTVYRR 837

  Fly   921 DFQSSLDRFTNYVKSKDKMPASGNLWPPFRLPHALPATSSFSDPCKILNSRIFHSTILSIFFRAV 985
            |.||::||:|.::|...:.  |||.|||::  ...|...|:....::|:.:..|..:.::.::.:
 Frog   838 DVQSAMDRYTAFLKQSGRF--SGNPWPPYK--KRSPLHHSYKGLMRLLHCKTLHIVLFTLLYKIL 898

  Fly   986 --HTRDVSEHLLALAVFLLEIAVETSDDVGSGTGDRAPPALAAVVESSSGPGYHGYGTGRHEPPK 1048
              | :::|||:|.:.::|:|:.:|.|            |...:..|:.:||.
 Frog   899 MDH-QNMSEHVLCMVLYLIELGLENS------------PEDESCEENFAGPD------------- 937

  Fly  1049 LFHC----YPTDNLSCNLRHVVKKVSLKSRDPQVITSSYRSNPFYSDLDFEVEADPEQSMRMIGQ 1109
              .|    :|..||.||:||.:..|  :.|.|                    |..||.      :
 Frog   938 --RCHDSWFPGSNLLCNMRHFINYV--RVRVP--------------------ETAPEV------R 972

  Fly  1110 GDPEGDEATGGAGLGMGAH-----SRRNVSQALVPMRVPGMEVALPPDLSVVAE-----TGVVIR 1164
            .:|....:|.|......|.     .|.|...|.|              .|:|||     ..::.|
 Frog   973 REPPASTSTDGPSSAQNARRPSLLQRENSGTAQV--------------FSLVAERRKKFQEIINR 1023

  Fly  1165 QDSNEDDLLREGNHAMDMSPPAALDFHFPLQQITLPESGMEVAIRRDLLLAETNNMGAIAGGAGG 1229
            .:|..:.::|..:.|:..:.|.|
 Frog  1024 NNSEANQVVRPKSSALKWTAPGA------------------------------------------ 1046

  Fly  1230 GANASATPPAGASNEMFSPTTPTGSGMLLPFQRVQPVAVPSSGNMDIVPSNAMGAGGSFTSGVSG 1294
                                ||..:.::
 Frog  1047 --------------------TPQLTTVI------------------------------------- 1054

  Fly  1295 SGTGRRMNYETGGARKRSVDIAIGGSNKDELHLDESILSLLLKLHSQLSGTLDSFS---LSDGED 1356
                                          |.:.||:||||:|||.:|||..||:.   |.|.|.
 Frog  1055 ------------------------------LEVKESMLSLLIKLHKKLSGKQDSYCPPWLDDPEC 1089

  Fly  1357 QSSDDDSTMDVDCNEASTSMAAAESTALAERGRSKRNYKNIHVSSSRIGDGPFFIGNLLRKIAKQ 1421
            ....|   :...|:                                  |||...:..:|.|.|.|
 Frog  1090 LVQPD---LPGYCH----------------------------------GDGVTAVERILLKAASQ 1117

  Fly  1422 DEQCAQSIDDIRARLWPNQREKQAEAKAREAKEKEERRKKARERQQKMMQDFANKQKLFMQSAAA 1486
            .....||||:|..:..|....|::....::...|||||:||||||||::.:||::||.||::|..
 Frog  1118 SRLNRQSIDEICKKAPPPVPPKKSSPADKKTLGKEERRQKARERQQKLLAEFASRQKSFMETAMD 1182

  Fly  1487 SSSGMGYGPEDEDDEEL--YEEQPREKEYDCIICNCTTPSTESNPIGLVVLVESSGIVGHRRRIA 1549
            ..|     ||.:...|:  .|:...|..|||:||..:.||||..|:|||||:::|.::||||:..
 Frog  1183 VES-----PESDVAMEIAGAEQHVAEPIYDCVICGQSGPSTEDRPLGLVVLLQASSVLGHRRKST 1242

  Fly  1550 ERLPLPINAEDESRLAHTTRLAAEFNRRTELLSLKFGDESWYLSNNMAYDNGVHVQSCGHHVHLS 1614
            |...||  ..:|.::......||..:.:..:|...|.|.|...|.::.::.||:||:|||.:|:.
 Frog  1243 EPKKLP--TTEEEQIYQEGTCAAANDVKLAILQRYFKDSSCLQSVSVGWEGGVYVQTCGHTLHID 1305

  Fly  1615 CLEAYLKTLYTTQRQPVQ----DRGEFYCPVCRQLSNSVLPLSP--QLDRPT-HLVRSGNQPFER 1672
            |.::|:::|  ...|.:|    |:|||.||:|||.:|||||..|  ..:|.: |...:.::..:.
 Frog  1306 CHKSYMESL--RNDQVLQGFSVDKGEFTCPLCRQFANSVLPCFPGDSTERGSWHSHAASSKSLQE 1368

  Fly  1673 LVADLTDLIKENETIP----QPTKLTEAMGHAMEVMTNIAQRKVKCSSITFRKL---FIFVTSIA 1730
            |:.::.||.::..|.|    ..|.|::.|...|:.:.:..|:|....|.|....   |:|:.|:|
 Frog  1369 LIKEVEDLQEQLGTFPVSISSETNLSKEMEAVMKDIKSTTQKKYTDYSKTQGSPDNDFLFMYSVA 1433

  Fly  1731 RTNLEAEIIQRGGSLCTANATRYKPKRECIVPLLHVLSVHVRVLVEWPLWSSWASLAGLPVTATE 1795
            |||||.|:|..|.:||:..|:. ..||.|:..|.|||::|:|:....|.::.|..|.  .|...:
 Frog  1434 RTNLELELIHCGDNLCSGGASA-AGKRSCLNQLFHVLAMHMRLYSIDPEYNPWKKLT--QVIQKK 1495

  Fly  1796 PLPAHCL------ELIPSILADPIALLLKFILLAPLQLDQDYFTCMVKVMYNLLYYQIVVQLCVT 1854
            |    .|      |.:|.:..|..:|||..:|..|..|.:::|.|:|||:|.|||.|.:..|.|.
 Frog  1496 P----SLGDDEEREEVPILFRDVTSLLLIQVLTMPQPLCKEHFVCIVKVLYTLLYTQAITSLSVK 1556

  Fly  1855 LTDLECDHIVKVYGSTSVGSDNSAAESQQQESAAGTTNNRRRAGQQQQSSSQLGKAMALVLSQTN 1919
            |                      .||.::.         .|.:|..::||...||....:|...
 Frog  1557 L----------------------QAEDRKV---------WRESGSSKKSSYSSGKPWEALLGFV- 1589

  Fly  1920 DLVHLRRDCIPSTSSSAAASAAGSSSTTSTNHGASAATASSATTIEVNLKSMELQLQALCLPFLR 1984
                        .|..:..|......|.|.|.....|....|         :|..||..||||||
 Frog  1590 ------------ISELSRGSLYQDEETDSINMSDFTAWYEDA---------IEHYLQQFCLPFLR 1633

  Fly  1985 VAALLRQHLYRHEMPEISAPGLEFVRLVYYLELVTDSMDWDCFNASKGLCFIPGTETTLPQFWCQ 2049
            :.:.|:.||:..::|...... ||..|...|.|:....:......|..|...|.:...|...||.
 Frog  1634 ITSFLQHHLFGLDLPSCQEED-EFTVLSNCLGLLPSFSEASHQFVSASLLDWPVSAFDLISQWCS 1697

  Fly  2050 Q--LMEVRPPADTVRELVLINQHSLWQQPRLLELPREYERLFTYYHERPCLNCYKVPKESSICLL 2112
            :  |...:.| |...  ||:.|.:.|..||||:||..|..:|.|||.:.|..|.||||:.::||:
 Frog  1698 EVNLFSDKHP-DQAN--VLLIQDTKWDLPRLLQLPENYNTIFQYYHRKCCSVCTKVPKDPALCLV 1759

  Fly  2113 CGTIVCLKQNCCAENDCCEAVRHTLSCGGGIGIFLVVTSTYIIVIRGRRACLWGSLYLDDFDEED 2177
            |||.||||..||.:...||.|.|:.:||.|.||||::.::.||:|||.|.|||||:|||...|||
 Frog  1760 CGTFVCLKGLCCKQQSYCECVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEED 1824

  Fly  2178 RDLKRGKPLYLSKDRFNLLESQWLSHKFAHTKHTWVFH 2215
            |||:||||||:.|:|:::||.||:||.|.|....|..|
 Frog  1825 RDLRRGKPLYICKERYSMLEQQWVSHTFDHINKRWGPH 1862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr3	NP_001259317.1	UBR-box_UBR3	224..292	CDD:439071	47/67 (70%)
		FliJ	<1410..1477	CDD:426581	26/66 (39%)
		RING-H2_UBR3	1601..1651	CDD:438146	25/53 (47%)
		PRT6_C	1722..2202	CDD:465944	170/490 (35%)
ubr3	XP_012826536.1	UBR-box_UBR3	79..150	CDD:439071	47/70 (67%)
		RING-H2_UBR3	1292..1344	CDD:438146	25/53 (47%)
		PRT6_C	1407..1849	CDD:465944	174/505 (34%)