Protein Alignment snz and MDM1

DIOPT Version :10

• Sequence 1: NP_572421.1
• Gene: snz / 31704
• FlyBaseID: FBgn0029976
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_013603.1
• Gene: MDM1 / 854867
• SGDID: S000004572
• Length: 1127
• Species: Saccharomyces cerevisiae
• Alignment Length: 1221
• Identity: 240/1221 - (19%)
• Similarity: 433/1221 - (35%)
• Gaps: 331/1221 - (27%)

  Fly    16 LPLFPIEPEPSVTATQRLTLLATRLLRALQLNWRIIVSGITLTLLAVIWYYPTFFLFFAFVVYSL 80
            :|.||         ..||.|:...|:..:|  |.:|                ||.|.|    :..
Yeast     1 MPKFP---------QFRLILVLFYLISMIQ--WSVI----------------TFSLGF----FLN 34

  Fly    81 VLVFAAVAGTVYIHYIFTTNEPTPPSRVPSRLLYNATKSNIFDLPKPIKNPSNLPLIFGKTVDLQ 145
            |.:||        :::|..:.|..|...|..:......||..|:.|.:|:...|.......:..:
Yeast    35 VCIFA--------YFVFFKSLPDLPKPQPRFVDIVPESSNTVDVDKELKSVEGLIQDGNAQIGKE 91

  Fly   146 LQQIIEYVLRDFMLPWLGYVVTKPKLIND-----VVREDLWNAIQKIHERALRMDAAKIIAVDMV 205
            |:.|:..:::||:.||.    ||....:|     |::..|...:..:.::.::.|:|.:|.:.::
Yeast    92 LESIVNLIIKDFVQPWF----TKIDKNSDAEFLKVIKWRLLQTLLVVKDKLMKNDSASLIVLKLL 152

  Fly   206 NRVTVHLEKIRIAEARAAETNTPPVFSTNSYLADEEKEMEF--------------------LRKL 250
            .....|..  ...:||.|..:...:....|...|.:..:||                    :.|.
Yeast   153 PIFNKHFS--TFCDAREAVLSDLTLERHKSANIDLQIAVEFNKNYKIHKSLSLKPNALQKEIEKS 215

  Fly   251 CEIMVILLLPRGY---SLPPLKV--LLSEILSYKIFFPMIKMLTAPDYINQKVV---QN------ 301
            ....||.|||..:   .|..|.|  |::|:|:..|..|:|...|.||..|.::|   ||
Yeast   216 IRKTVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIFKFTDPDSWNLRIVSLSQNYFEEKH 280

  Fly   302 ----IETRLAAAAMSKR---------------------SYEYAA-SFEDFLKIINNSGNLEELSL 340
                |...|:......|                     :.||.. .||.:|..:::..:|.::..
Yeast   281 KVHKIRRMLSKELQDHRKVMNDVANKDVGEPSSEKLELNAEYTGKQFEHYLNQLDSLLDLSDIKY 345

  Fly   341 IRKSIVNDLMHA-----TTMQNLQRAK----GLDPDHEDHSLSKSEL-TAAVRLKRYVR--QLTM 393
            :..|:...:...     .|.:||:..|    .|:......|...||: ||:.:|.|...  .|.|
Yeast   346 VAYSLALKIYQLKENEHLTKENLKYKKRLLLSLNLIESKLSFPGSEIDTASKKLAREANYPDLNM 410

  Fly   394 AKGECEKNLAKFGWNGNYSSDIDLTLVEILNTAVGRRYFTLFLEPL---KASALIGFYLAVEEIK 455
            ..|...|.:|.|        ...:||.:|::.:....:|..||..:   :.|..:.:...:|..|
Yeast   411 DNGIVLKEMASF--------LTSITLKDIVDDSEFLPFFESFLGSVPETQGSTFLEYSQTIESFK 467

  Fly   456 HAHKSAS----------------HQLGTEIFYT---------------YIRVPKSEIQIDKHERK 489
            :..:.|:                .::.::.|:.               .|.:.::..||:..|
Yeast   468 NPLEDATSEDIISGYSGISTMQLQEISSKFFHNNNLQNMKLLDEGLVKNIILFRNSFQINNDE-- 530

  Fly   490 LIETFLLGDAEPDIFYDIQRNVLRTLEEKYYPPFVLSDQYRQLKEALDSNEIADPTLLMCH---T 551
              :||:|  |...:.. :|...::.|::::.|.|..:..:.::   |.::.|.. |.:..|   .
Yeast   531 --DTFIL--ARKSVLL-LQTEAIKYLDDRFLPLFKKTPSFLKM---LSTSHIIS-TDIYAHFLSR 586

  Fly   552 IGDVQEPLADE------------------QPGAADGLNGGAGGA------IDVAAHTSYAR---- 588
            ||.|..|..::                  .||..|.|:....|:      ..::::..|::
Yeast   587 IGGVNNPEQNKIIKDNVKTDFMNPVRIFANPGITDALDNIVNGSGSKPHKSRISSNPRYSQLFGS 651

  Fly   589 -------------------------------RKLEQIQERIDKKNQALDALKY----SVKPESKV 618
                                           |.:|::.  :...|..|:..::    :.:.....
Yeast   652 ENDNIFKDKLFDDENDNTSEISVVEDQLDHPRNMEKVS--VSSGNSGLNPSQFYGSNNFRDNIAS 714

  Fly   619 LTI----LEKEMEWLKSEKRQTEAHLRRTDAWTEHLGKWKATIQSVEVSDEKESL--QFMILVHV 677
            |||    :|||:|.|:  ....:|.|.......:.|.|.:.|:  ::..:.||.|  |:|    |
Yeast   715 LTISIDQIEKELELLR--HLILKADLTNNQMQLKILKKSQRTL--LKELEMKELLKQQYM----V 771

  Fly   678 DEDINAPVQPTS-------SKNGDSG-------HANLRKRPSGISSGWVVMRSLNQVHELQ---- 724
            .|:.|:..:.|.       |:|..:|       ..|:....:|..|.|.:.|..|:..||.
Yeast   772 QENGNSLFRKTKIYIRSYFSENSSNGLKEITYYIINIHHFNNGQVSSWDMARRYNEFFELNTYLK 836

  Fly   725 ---RKLRHVSSNLKAIDLPTNFKFFFLKTDRHGQEKAKSQIQKFLNFILEDDHLNGSEAIYTFLS 786
               |.|.....:|....:..:.|:...||..:  |:.|.:::|:|..:|....:........||:
Yeast   837 KNFRDLMRQLQDLFPSKVKMSLKYHVTKTLLY--EERKQKLEKYLRELLSISEICEDNIFRRFLT 899

  Fly   787 PSSDHLKQSLPSPKKSKFSLSTLFRSD---AGKAHEASKATDPFWGLQRDDEDISTYLD---GES 845
            .         |:|    |.|:..:..|   ....||      |. |......:.|:.:|   .|.
Yeast   900 D---------PTP----FKLNKEYMHDDILEEPLHE------PI-GSSNSTSNSSSVVDLQSSED 944

  Fly   846 GGEAKMLAADLDSKDSIAEPMY----ALMGEIFDM-----------GGVFKWLR-KSLISFVQIT 894
            |||......:.........|.|    :.:.:|.|:           .|   ||| :::|:.:|..
Yeast   945 GGELNFYEDERHFFTDSGYPFYSQNKSFVKQICDLFISLFALNKANAG---WLRGRAIITVLQQL 1006

  Fly   895 YGRTINRQIRESVAYLFEESMLHNYFSAILKSFWPGGVL------ASAYPTRSEDMREMTTTAAK 953
            .|.||.:.|:.|:..|..|..:...........|....|      .:|..||||..|..|...|.
Yeast  1007 LGSTIEKYIKVSIQKLRSEDQVFEAIVTFKNMLWGDNGLFERKRNETAEATRSEGERLRTEQLAL 1071

  Fly   954 ALLTDHIPEVLCNLVGAQAAKRGVLKVFDALQNPAYNKQLFYELLEILMIE 1004
            ..|.....:....:||.:.:.....:|...||||..|..|..|.|:.::::
Yeast  1072 TSLQRLFADTCGRVVGLRDSHEAAGRVHAMLQNPYLNASLLLEALDAILLD 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_572421.1	PXA	142..300	CDD:460484	42/190 (22%)
		RGS_SNX25	422..531	CDD:188675	21/142 (15%)
		PX_SNX25	645..788	CDD:132788	36/165 (22%)
		Nexin_C	882..987	CDD:462541	28/111 (25%)
MDM1	NP_013603.1	PXA	85..276	CDD:214611	44/196 (22%)
		RGS	462..567	CDD:470619	16/111 (14%)
		PX_MDM1p	763..900	CDD:132786	32/142 (23%)
		Nexin_C	993..1106	CDD:462541	29/112 (26%)