Protein Alignment snz and Snx25

DIOPT Version :10

• Sequence 1: NP_572421.1
• Gene: snz / 31704
• FlyBaseID: FBgn0029976
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_001419741.1
• Gene: Snx25 / 306471
• RGDID: 1310150
• Length: 986
• Species: Rattus norvegicus
• Alignment Length: 979
• Identity: 314/979 - (32%)
• Similarity: 506/979 - (51%)
• Gaps: 129/979 - (13%)

  Fly    79 SLVLVFAAVA---GTVYIHYIFTTNEPTPPS------------RVPSRLLYNATKSNIFDLPKPI 128
            ||.|..||.|   ||: :..:..:....||.            |.|.|       |.::..|:
  Rat    79 SLYLSCAAAALLLGTL-VALVCWSPRAQPPDFASSWSRLAAAVRCPLR-------SPVYGNPQ-- 133

  Fly   129 KNPSNLPLIFGKTVDLQLQQIIEYVLRDFMLPWLGYVVTKPKLINDVVREDLWNAIQKIHERALR 193
            :......::....:|..|:.:.:|..||::|.|.|.:......:..::.:|.|:..::|..|...
  Rat   134 ETAQGRRVVISHNMDRALKDVFDYSYRDYILSWYGNLSRDDGQLYHLLLDDFWDIAKQIRYRLSH 198

  Fly   194 MDAAKIIAVDMVNRVTVHLEKIRIAEARAAETNTPPVFSTNSYLADEEKEMEFLRKLCEIMVILL 258
            :|..|::..|:|..:..|...::.|.||..|...|  |..::.|.|...|:.||:...:::|..|
  Rat   199 VDVVKVVCNDIVKALLTHFCDLKAATARHEEQPRP--FVLHACLKDSHDEVRFLQTCSQVLVFCL 261

  Fly   259 LP-RGYSLPPLKVLLSEILSYKIFFPMIKMLTAPDYINQKVVQNIETRLAAAAMSKRSYEYAASF 322
            || :......|:.:|:|||:.|:..|::::|:.||||||.::..:|.|...:...||:|.||.|:
  Rat   262 LPSKDIQSLSLRTMLAEILTTKVLKPVVELLSNPDYINQMLLAQLEYREQMSGHHKRAYTYAPSY 326

  Fly   323 EDFLKIINNSGNLEELSLIRKSIVNDLMHATTMQN---LQRAKGLDPDHEDHSLSKSELTAAVRL 384
            |:|:|:||::.::|.|..:|..||.:::.|||:.:   |:|.||     ::.:..|::|..|..:
  Rat   327 EEFIKLINSNSDVEFLKQLRYQIVVEIIQATTISSFPQLKRHKG-----KESAAMKTDLLRARNM 386

  Fly   385 KRYVRQLTMAKGECEKNLAKFG--------------WNGNYSSDIDLTLVEILNTAVGRRYFTLF 435
            |||:.|||:||.:|||.:...|              ..|..|..| |...:|:.....|..|..:
  Rat   387 KRYINQLTVAKKQCEKRIRILGGPAYDQQEDGVSDEGEGPQSQKI-LQFEDIMTNPFYRERFGTY 450

  Fly   436 LEPLKASALIGFYLAVEEIKHAHKSASHQLGTEIFYTYIRVPKSEIQIDKHERKLIETFLLGDAE 500
            :|.:...||:||:.:||.:|:|:|:...||.:|::..:. |...||.::|...|.|:..|:|:..
  Rat   451 MERIDKRALVGFWESVEHLKNANKNEIPQLVSEMYQNFF-VESKEIPVEKSLYKEIQQCLVGNKG 514

  Fly   501 PDIFYDIQRNVLRTLEEKYYPPFVLSDQYRQLKEALDSNEIADPTLLMCHTIGDVQEPLADEQPG 565
            .::|..||.:|...|.::|||.|::||.|.:|                   |.:.:|...|.|..
  Rat   515 IEVFSKIQGDVYDVLRDRYYPSFLVSDLYEKL-------------------IHEEEEETPDSQLA 560

  Fly   566 AAD---GLNGGAG-----GAIDVAAHTSYARRKLEQIQERIDKKNQALDALKYSVKPESKVLTIL 622
            :..   |..|.||     |...|:...|:|..||.::.|:::.|.|||.:::.:.||:.|:::.|
  Rat   561 SGKDELGSGGEAGEEVVEGTSGVSDPASFAVIKLRELSEKLEYKRQALSSIQNAPKPDKKIISKL 625

  Fly   623 EKEMEWLKSEKRQTEAHLRRTDAWTEHLGKWKATIQSVEVSDEK-ESLQ-FMILVHVDEDINAPV 685
            :.|:..::.|....:.|:.|||.|.||||.|||:|.|.||::|. |.:. :.:.|::.|     |
  Rat   626 KDEILVIEKECTDLQLHMARTDWWCEHLGLWKASITSAEVTEENGEQMPCYFVRVNLQE-----V 685

  Fly   686 QPTSSKNGDSGHANLRKRPSGISSGWVVMRSLNQVHELQRKLRHVSSNLKAIDLPTNFKFFFLKT 750
            ....:||                  |.|.|.|::...|.|||.....:||.:.||:..|..|...
  Rat   686 GGVETKN------------------WTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSI 732

  Fly   751 DRHGQEKAKSQIQKFLNFILEDDHLNGSEAIYTFLSPSSDHLKQSLPSPKKSKFSLSTLFRSDAG 815
            |....||:|:|:.|||..:|.|:.|..|||:|.|||||.|:||......||:.||||:..
  Rat   733 DHKFLEKSKNQLNKFLQNLLSDERLFQSEALYAFLSPSPDYLKVIDVQGKKTSFSLSSFL----- 792

  Fly   816 KAHEASKATDPFWGLQ----RDDEDISTYLDGESGGEAKMLAADLDSKDSIAEPMYALMGEIFDM 876
                 .|....|:..|    .:|.|:|.|.|...|           .||::|||.:.|:||||::
  Rat   793 -----EKLPRDFFSHQEEEIEEDSDLSDYGDDVDG-----------KKDALAEPCFMLIGEIFEL 841

  Fly   877 GGVFKWLRKSLISFVQITYGRTINRQIRESVAYLFEESMLHNYFSAILKSFWPGGVLASAYPTRS 941
            .|:|||:|::||:.||:|:|||||:|||::|.::|.|.|:..|.||...:|||.|.||.....||
  Rat   842 RGMFKWVRRTLIALVQVTFGRTINKQIRDTVNWIFSEQMVVYYISAFRDAFWPNGKLAPPTRIRS 906

  Fly   942 EDMREMTTTAAKALLTDHIPEVLCNLVGAQAAKRGVLKVFDALQNPAYNKQLFYELLEILMIEFF 1006
            |...:.|...|:..|.::||:.|.:|||.|.|:.|::|:|.|||....||.|.|.|:|:|:.|..
  Rat   907 EAQSQETKQRAQQKLLENIPDTLQSLVGQQNARHGIIKIFKALQETRANKHLLYVLMELLLTELC 971

  Fly  1007 PEIR 1010
            ||:|
  Rat   972 PELR 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_572421.1	PXA	142..300	CDD:460484	46/158 (29%)
		RGS_SNX25	422..531	CDD:188675	36/108 (33%)
		PX_SNX25	645..788	CDD:132788	51/144 (35%)
		Nexin_C	882..987	CDD:462541	48/104 (46%)
Snx25	NP_001419741.1	PXA	148..303	CDD:460484	46/156 (29%)
		RGS	437..545	CDD:470619	36/108 (33%)
		PX_SNX25	648..770	CDD:132788	51/144 (35%)
		Nexin_C	847..953	CDD:462541	48/105 (46%)