Protein Alignment snz and Snx14

DIOPT Version :10

• Sequence 1: NP_572421.1
• Gene: snz / 31704
• FlyBaseID: FBgn0029976
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_001346887.2
• Gene: Snx14 / 244962
• MGIID: 2155664
• Length: 946
• Species: Mus musculus
• Alignment Length: 1137
• Identity: 226/1137 - (19%)
• Similarity: 397/1137 - (34%)
• Gaps: 363/1137 - (31%)

  Fly    14 RRLPLFPIEPEPSVTATQRLTLLATRLLRALQLNWRIIVSGITL-------TLLAVIWYYPTFFL 71
            |:.|||..    .:......:||..|.|..|.:.|..:...:|.       :||      |..|.
Mouse    26 RQYPLFCF----LLLCLSVASLLLNRYLHVLMIFWSFVAGVVTFYCSLGPDSLL------PNIFF 80

  Fly    72 FFAFVVYSLVL--VF-----AAVAGTVYIHYIFTTNEPTPPSRVPSRLLYNATKSNIFDLPKPIK 129
            ...:....|.|  :|     .||.|.|..           ....||.||.|.         :|.
Mouse    81 TIKYKPKQLGLQELFPQGHSCAVCGKVKC-----------KRHRPSLLLENY---------QPW- 124

  Fly   130 NPSNLPLIFGKTVDLQLQQIIEYVLRDFMLPWLGYVVTKPKLINDV---VREDLWNAIQKIHERA 191
                |.|.....||..|.:::|.||.:|:.||...|......::::   :|......:::||
Mouse   125 ----LDLKVSSKVDASLSEVLELVLENFVYPWYRDVTDDESFVDELRITLRFFASVLVRRIH--- 182

  Fly   192 LRMDAAKIIAVDMVNRVTVHLEKIRIAEARAAETNTPPVFSTNSY-------LADEEKEMEFLRK 249
             ::|...||...::.....|:|.|..|..:...|......:...|       |.....|:::|||
Mouse   183 -KVDIPSIITKKLLKAAMKHIEVIVKARQKVKNTEYLQQAALEEYGPELHVALRSRRDELQYLRK 246

  Fly   250 LCEIMVILLLPRGYSLPP-------LKVLLSEILSYKIFFPMIKMLTAPDYINQKVVQNIETRLA 307
            |.|    ||.|  |.|||       |.:|:.||||..:..|.:..|..||.:|..::..|:.
Mouse   247 LTE----LLFP--YILPPKATDCRSLTLLIREILSGSVLLPSLDFLADPDTVNHLLIIFIDD--- 302

  Fly   308 AAAMSKRSYEYAASFEDFLKIINNSGNLEELSLIRKSIVNDLMHATTMQNLQRAKGLDPDHEDHS 372
              :..:::.|.|:....||:                                  |..:|.::..|
Mouse   303 --SPPEKATEPASPLVPFLQ----------------------------------KFAEPRNKKPS 331

  Fly   373 LSKSELTAAVRLKRYVRQLTMAKGECEKNLAKFGWNGNYSSDIDLTLVEILNTAVGRRYFTLFLE 437
            :.|.||       :.:|:                     ..|:   |...:|          ||:
Mouse   332 VLKLEL-------KQIRE---------------------QQDL---LFRFMN----------FLK 355

  Fly   438 PLKASALIGFYLAVEEIKHAHKSASHQLGTEIFYTYIRVPKSEIQIDK----HE--RKLIETFLL 496
            ...|..::.|.|.|||...                  |:.:.|:..|:    ||  :|:.:|:.|
Mouse   356 QEGAVHVLQFCLTVEEFND------------------RILRPELSNDEMLSLHEELQKIYKTYCL 402

  Fly   497 GDA------EPDIFYDIQR-----------------------NVLRTLEEKYYPPFVLSDQY-RQ 531
            .::      :|.|..:|||                       :||..||..:.|.|..||:| ||
Mouse   403 DESIDKIRFDPFIVEEIQRIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQ 467

  Fly   532 LKEALDSNEIADPTLLMCHTIGDVQEPLAD----EQPGAADGLNGGAGGAIDVAAHTSYARRKLE 592
            |....:|     ||.......|.:.  |.|    ::.|.:.|::
Mouse   468 LLRGAES-----PTRNSKFNRGSLS--LDDFRSTQKRGESFGIS--------------------- 504

  Fly   593 QIQERIDKKNQALDALKYSVKPESKVLT---ILEKEMEWLK------SEKRQTEAHLRRTDAWTE 648
                ||..|   :..:..|...|..||.   :.|.|.::::      .:....||  ..|.....
Mouse   505 ----RIGSK---IKGVFKSTTMEGAVLPNYGVAEGEDDFIEEGIVVMEDDSPVEA--VSTPNTPR 560

  Fly   649 HLGKWKATIQSVEV-----SDEKESLQFMILVHVDEDINAPVQPTSSKNGDSGHANLRKRPSGIS 708
            :|..||.:|..|:.     |:.||..:.:.:..:|.:                 .|.|:......
Mouse   561 NLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVE-----------------RNDRRAVGHEP 608

  Fly   709 SGWVVMRSLNQVHELQRKLRHVSSNLKAIDLPT-------NFKFFFLKTDRHGQEKAKSQIQKFL 766
            ..|.|.|...:.:.|:.||...........||:       |::  |||:.|       .:.|::|
Mouse   609 EHWSVYRRYLEFYVLESKLTEFHGTFPDAQLPSKRIIGPKNYE--FLKSKR-------EEFQEYL 664

  Fly   767 NFILEDDHLNGSEAIYTFLSPS---SDHLKQSLPSPKKSKFSLSTLFRSDAGK-AHEASKATDPF 827
            ..:::...|:.|:.:..||||:   :..|.:.||.     .:|..:.:|..|| ..|..:..:||
Mouse   665 QKLVQHPELSNSQLLADFLSPNGGETQFLDKILPD-----VNLGKIIKSVPGKLMKEKGQHLEPF 724

  Fly   828 WGLQRDDEDISTYLDGESGGEAKMLAADLDSKDSIAEPMYALMGEIF------------------ 874
                     |.::::.....:.|....:|......:|....|..::|
Mouse   725 ---------IMSFINSCESPKPKPSRPELTILSPTSENNKKLFNDLFKNNANRAENTERKQNQNY 780

  Fly   875 -----DMGGVF--------------KWLRKSLISFVQITYGRTI----NRQIRESVAYLFEESML 916
                 .:.||:              .||...|:. .:|.:..|:    :..::..:..||:|..|
Mouse   781 FMEVMTVDGVYDYLMYVGRVVFQVPDWLHHLLMG-TRILFKNTLEMYTDYYLQCKLEQLFQEHRL 844

  Fly   917 HNYFSAILKSFWPGGVLASAYPTRSEDMREMTTTAAKALLTDHIPEVLCNLVGAQAAKRGVLKVF 981
            .:..:.:..:.:    ..:..|...:|.::......:.:: ::||:::...:|.:.....:..:|
Mouse   845 VSLITLLRDAIF----CENTEPRSLQDKQKGAKQTFEEMM-NYIPDLIVKCIGEETKYESIRLLF 904

  Fly   982 DALQNPAYNKQLFYELLEILMIEFFPEIRQLR 1013
            |.||.|..||||.|.||:|::.|.|||:.:::
Mouse   905 DGLQQPVLNKQLTYVLLDIVIQELFPELNKVQ 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snz	NP_572421.1	PXA	142..300	CDD:460484	47/174 (27%)
		RGS_SNX25	422..531	CDD:188675	31/144 (22%)
		PX_SNX25	645..788	CDD:132788	31/154 (20%)
		Nexin_C	882..987	CDD:462541	18/108 (17%)
Snx14	NP_001346887.2	PXA	130..299	CDD:460484	47/178 (26%)
		RGS_SNX14	340..466	CDD:188677	34/177 (19%)
		PX_SNX14	564..686	CDD:132787	30/147 (20%)
		Nexin_C	807..911	CDD:462541	18/109 (17%)