Protein Alignment Ir7c and Grin2a

DIOPT Version :10

• Sequence 1: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_036705.3
• Gene: Grin2a / 24409
• RGDID: 2737
• Length: 1464
• Species: Rattus norvegicus
• Alignment Length: 711
• Identity: 145/711 - (20%)
• Similarity: 263/711 - (36%)
• Gaps: 169/711 - (23%)

  Fly    17 WAIDNYYGMATSTPLAVVQFPTSRESRRLHNDLIDAALGRSSGTGRIQFLLEDDRV-EMTETDTD 80
            |.:.|...:.||...|..|.    :.:::|:.:|            :.:..:|:.| .::|..:
  Rat   198 WDMQNVITLDTSFEDAKTQV----QLKKIHSSVI------------LLYCSKDEAVLILSEARS- 245

  Fly    81 PPPPSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLEDQPMESLKIMFRRL 145
                .||||... .|.:.||.| ...|:...:..|     |...|.|    |....||:...|..
  Rat   246 ----LGLTGYDF-FWIVPSLVS-GNTELIPKEFPS-----GLISVSY----DDWDYSLEARVRDG 295

  Fly   146 LNMYVLNVNVFLQRDGTVHLYTYYP------YG-------PHHCQSSLPVYYT-AFQDLAAPANG 196
            |.:.....:..|::      ::|.|      ||       |.|......|..| ..:||:....|
  Rat   296 LGILTTAASSMLEK------FSYIPEAKASCYGQAEKPETPLHTLHQFMVNVTWDGKDLSFTEEG 354

  Fly   197 F----------------------------GLTKPLFPRKLTNMHGCE-----MVVATFEHRPYVI 228
            :                            .|...::|| ..:...||     :.:.|.|..|:||
  Rat   355 YQVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPR-YKSFSDCEPDDNHLSIVTLEEAPFVI 418

  Fly   229 IED-DPKT--------PGGRSI----HGIEGL------------IFRSLAERMNFTIKLVEQKDK 268
            :|| ||.|        |..:.:    ...||:            |.:.|:..:.||..|....:.
  Rat   419 VEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG 483

  Fly   269 NRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVVPSGGSISPM 332
            ..|:.: :..:.|::..:|.....:.......::.||:::..|..:....| |:|..|.|::||.
  Rat   484 KHGKKV-NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 547

  Fly   333 GRLTRPFRYIIWSCILVS-LIFGFVLICLLKITALPGL-RNLVLGRRNRLPFM----GMWASLLG 391
            ..| .||...:|..:.|. ||...:.:.:.:..:..|. |||..|:....|..    .:|  ||.
  Rat   548 AFL-EPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIW--LLW 609

  Fly   392 GLA------LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVLAKDYE 450
            ||.      :.||:...::.::.:|....:|..|:||..|...:...|....:..||     |.:
  Rat   610 GLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLS-----DKK 669

  Fly   451 FRILPALRTIFKDSMPTTNFHAVL--SLEESL---------YRLRDEDDPGITVALLQPTVNQFD 504
            |: .|      .|..|...|..|.  |.|.::         |..| .:..|:..||:.....:.|
  Rat   670 FQ-RP------HDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTR-FNQRGVEDALVSLKTGKLD 726

  Fly   505 ----------FRSGPNK--RHLTVLPDPLM-TAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARY 556
                      :::|.::  :.:|:....:. |......::..|.:||:||..::..:..|.:...
  Rat   727 AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL 791

  Fly   557 RKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEILTTNHRRLRRAF 617
            ..:::..|.. :::..:....|.|..::|:|...|....::||.||.|.|.  :.:||..|
  Rat   792 ETLWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF--YWKLRFCF 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/86 (21%)
		Lig_chan	343..592	CDD:459656	55/284 (19%)
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	42/226 (19%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	85/416 (20%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1	599..620		5/22 (23%)
		NMDAR2_C	839..1464	CDD:463148	4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464