Protein Alignment Ir7c and Grin3b

DIOPT Version :10

• Sequence 1: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_579842.2
• Gene: Grin3b / 170796
• RGDID: 621705
• Length: 1002
• Species: Rattus norvegicus
• Alignment Length: 738
• Identity: 145/738 - (19%)
• Similarity: 257/738 - (34%)
• Gaps: 228/738 - (30%)

  Fly    14 ALVWAIDNYYGMATSTPLAVVQFPTSRESRRLHNDLIDAALGRSSGTGRIQFLLEDDRVEMTETD 78
            ||:.|::   |..|..|.||:                   ||.|  |.|...:||
  Rat   220 ALLGALE---GGGTPVPAAVL-------------------LGCS--TARAHEVLE---------- 250

  Fly    79 TDPPPPSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLE--DQPMESLKIM 141
            ..||.|..|.|.|:....|.:.    .|...:..||.. :::....|::..:|  .|.:.|:.::
  Rat   251 AAPPGPQWLLGTPLPAEALPTT----GLPPGVLALGET-EQHSLEAVVHDMVELVAQALSSMALV 310

  Fly   142 F-RRLLNMYVLNVN-----------------------------VFLQRDGTVHLYTYY------- 169
            . .|.|...|:|.:                             |::.....||:..::
  Rat   311 HPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVWVTGSSQVHVSRHFKVWSLRR 375

  Fly   170 -PYGPHHCQSSLPVYYT--AFQD-----------LAAPANGFGLTKPLFPRKLTNMHGCEMVVAT 220
             |.|       .|.:.|  ::||           |..|:......:|    ||       .||..
  Rat   376 DPLG-------APAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARP----KL-------RVVTL 422

  Fly   221 FEHRPYVII---EDDPKTPGG-------------------------------RSIHGIEGLIFRS 251
            .|| |:|..   ::|.:.|.|                               |..:|....:...
  Rat   423 VEH-PFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLER 486

  Fly   252 LAERMNFTIKLVEQKDKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTS 316
            |||.:.|..:|....|...| .|.||.:||::..::.|..::....|..:.|||.::..::.:.|
  Rat   487 LAEDLAFDFELYIVGDGKYG-ALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFS 550

  Fly   317 FPIVLVVPSGGSISPMGRLTRPFRYIIWSCILVSLIFGFVLICLLKITALPGL------RNLVLG 375
            ..:.::|.:..:.||:|....|..:.:|..:..:|....:.:.|.:..:..||      |..|..
  Rat   551 TSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFS 615

  Fly   376 RRNRLPFMGMWASLLG-GLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLL----------- 428
            ..:.|..  .:|.|.| .::...|:....|:::.:|.:..|::.::||..|..:
  Rat   616 YSSALNL--CYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELS 678

  Fly   429 -LQDVEMRSPIK-----SLSEVLAKDYEFRILPALRT-IFKDSMPTTNFHAVLSLEESLYRLRDE 486
             :.|.::..|.:     ::.|..|:.|.....|.:.. :.:.|.|||. |.|..|        ..
  Rat   679 GIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTP-HGVAML--------TS 734

  Fly   487 DDPGITVALLQPTVNQFDFRSGPNKRHLTV------------LPDPLMTAPLTFYMRPHSYFKRR 539
            |.|.:...::..::..::.....:.:.|||            ||   ..:|||          ..
  Rat   735 DPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLP---QNSPLT----------SN 786

  Fly   540 IDRLIMAMMSSGIV----ARYRKMYM--DRIKRVSKRRNLEPKPLSIWRLSGIFV-CCAGLYLVA 597
            :...|....|||.:    .::.||..  .|:..|:     |...:.::..||:|| .|.||....
  Rat   787 LSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVT-----ETLQMGVYHFSGLFVLLCLGLGSAL 846

  Fly   598 LI-----VFILEILTTNHRRLRR 615
            |.     ||...:|.    |:||
  Rat   847 LTSLGEHVFYRLVLP----RIRR 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	19/95 (20%)
		Lig_chan	343..592	CDD:459656	55/292 (19%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	19..401	CDD:380600	42/226 (19%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	82/430 (19%)
		Lig_chan	574..841	CDD:459656	55/295 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250|UniProtKB:Q91ZU9	951..984