Protein Alignment Ir7c and Grin2a

DIOPT Version :10

• Sequence 1: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 704
• Identity: 140/704 - (19%)
• Similarity: 265/704 - (37%)
• Gaps: 155/704 - (22%)

  Fly    17 WAIDNYYGMATSTPLAVVQFPTSRESRRLHNDLIDAALGRSSGTGRIQFLLEDDRV-EMTETDTD 80
            |.:.|...:.||...|..|.    :.:::|:.:|            :.:..:|:.| .::|..:
Mouse   198 WDMQNVITLDTSFEDAKTQV----QLKKIHSSVI------------LLYCSKDEAVLILSEARS- 245

  Fly    81 PPPPSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLEDQPMESLKIMFRRL 145
                .||||... .|.:.||.| ...|:...:..|     |...|.|    |....||:...|..
Mouse   246 ----LGLTGYDF-FWIVPSLVS-GNTELIPKEFPS-----GLISVSY----DDWDYSLEARVRDG 295

  Fly   146 LNMYVLNVNVFLQRDGTVHLYTYYP------YG-------PHHCQSSLPVYYT-AFQDLAAPANG 196
            |.:.....:..|::      ::|.|      ||       |.|......|..| ..:||:....|
Mouse   296 LGILTTAASSMLEK------FSYIPEAKASCYGQTEKPETPLHTLHQFMVNVTWDGKDLSFTEEG 354

  Fly   197 F----------------------------GLTKPLFPRKLTNMHGCE-----MVVATFEHRPYVI 228
            :                            .|...::|| ..:...||     :.:.|.|..|:||
Mouse   355 YQVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPR-YKSFSDCEPDDNHLSIVTLEEAPFVI 418

  Fly   229 IED-DPKT--------PGGRSI----HGIEGL------------IFRSLAERMNFTIKLVEQKDK 268
            :|| ||.|        |..:.:    ...||:            |.:.|:..:.||..|....:.
Mouse   419 VEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG 483

  Fly   269 NRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVVPSGGSISPM 332
            ..|:.: :..:.|::..:|.....:.......::.||:::..|..:....| |:|..|.|::||.
Mouse   484 KHGKKV-NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 547

  Fly   333 GRLTRPFRYIIWSCILVS-LIFGFVLICLLKITALPGL-RNLVLGRRNRLPFM----GMWASLLG 391
            ..| .||...:|..:.|. ||...:.:.:.:..:..|. |||..|:....|..    .:|  ||.
Mouse   548 AFL-EPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIW--LLW 609

  Fly   392 GLA------LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEV------ 444
            ||.      :.||:...::.::.:|....:|..|:||..|...:...|....:..||:.
Mouse   610 GLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPH 674

  Fly   445 -LAKDYEFRILP--ALRTIFKDSMP-----TTNFHAVLSLEESLYRLRDEDDPGITVALLQPTVN 501
             .:..:.|..:|  :.....:::.|     .|.|:. ..:|::|..|:    .|...|.:....
Mouse   675 DYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQ-RGVEDALVSLK----TGKLDAFIYDAA- 733

  Fly   502 QFDFRSGPNK--RHLTVLPDPLM-TAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDR 563
            ..::::|.::  :.:|:....:. |......::..|.:||:||..::..:..|.:.....:::..
Mouse   734 VLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTG 798

  Fly   564 IKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEILTTNHRRLRRAF 617
            |.. :::..:....|.|..::|:|...|....::||.||.|.|.  :.:||..|
Mouse   799 ICH-NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF--YWKLRFCF 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/86 (21%)
		Lig_chan	343..592	CDD:459656	50/277 (18%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	42/226 (19%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	80/409 (20%)
		NMDAR2_C	839..1464	CDD:463148	4/13 (31%)