Protein Alignment Ir7c and grin2b

DIOPT Version :10

• Sequence 1: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 636
• Identity: 120/636 - (18%)
• Similarity: 229/636 - (36%)
• Gaps: 162/636 - (25%)

  Fly    76 ETDTDPPP-PSGLTGRPIAIWFLD---------SLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGL 130
            :|||.|.. |:||.......|..|         ::.:.....|.......|..::..:.:
 Frog   260 DTDTVPAEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKSSCYNI----- 319

  Fly   131 EDQPMESLKIMFRRLLNMYVLNV-----NVFLQRDGTVHLYTYYP---------------YGPHH 175
                 :..::....:|..|::||     |:....||    |..:|               .|.:.
 Frog   320 -----QESRVYEAHMLKRYLINVTFEGRNLSFSEDG----YQMHPKLVIILLNQQRKWERVGKYK 375

  Fly   176 CQSSLPVYYT--AFQDLAAPANGFGLTKPLFPRKLTNMHGCE-MVVATFEHRPYVIIED-DPKT- 235
            .:|....||.  .|:              |:|.  :..|..| :.:.|.|..|:||:|| ||.:
 Frog   376 DRSLKMKYYVWPVFE--------------LYPN--SEEHKDEHLSIVTLEEAPFVIVEDVDPLSG 424

  Fly   236 --------------------PGG----RSIHGIEGLIFRSLAERMNFTIKLVEQKDKNRGEILPD 276
                                .||    |...|....|.:.:|:.:.||..|....:...|:.: :
 Frog   425 TCMRNTVPCRKQIRTENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKI-N 488

  Fly   277 GNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVVPSGGSISPMGRLTRPFR 340
            |.:.|::..:|.....:.......::.||:::..|..:....| |:|..|.|::||...| .||.
 Frog   489 GTWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFL-EPFS 552

  Fly   341 YIIWSCILVSLIFGFVLICLLKITAL--------------------PGLRNLVLGRRNRLPFMGM 385
            ..:|       :..||::.::...|:                    ||..:..:|:       .:
 Frog   553 ADVW-------VMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGK-------AI 603

  Fly   386 WASLLGGLA------LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEV 444
            |  ||.||.      :.||:...::.::.:|....:|..|:||..|...:...|....:..||
 Frog   604 W--LLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLS-- 664

  Fly   445 LAKDYEFR----ILPALR--TIFKDSMPTTNFHAVLSLEESLYRLRDEDDPGITVALLQPTVNQF 503
               |.:|:    ..||.|  |:...|......:..|.:...:.:....   .:..|||.....:.
 Frog   665 ---DKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQR---SVQDALLSLKTGKL 723

  Fly   504 D----------FRSGPNK--RHLTVLPDPLM-TAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVAR 555
            |          :.:|.::  :.:|:....:. |......::..|.:||::|..|:.:...|.:..
 Frog   724 DAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEE 788

  Fly   556 YRKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEIL 606
            ...:::..|.. :::..:....|.|..::|:|...|....::||.||:|.|
 Frog   789 LEALWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHL 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	19/87 (22%)
		Lig_chan	343..592	CDD:459656	49/293 (17%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	22/136 (16%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	81/426 (19%)
		NMDAR2_C	837..1449	CDD:463148	1/2 (50%)