DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hira and hip1

DIOPT Version :9

Sequence 1:	NP_572401.2	Gene:	Hira / 31680	FlyBaseID:	FBgn0022786	Length:	1047	Species:	Drosophila melanogaster
Sequence 2:	NP_596575.1	Gene:	hip1 / 2540219	PomBaseID:	SPBC31F10.13c	Length:	932	Species:	Schizosaccharomyces pombe

Alignment Length:	982	Identity:	262/982 - (26%)
Similarity:	440/982 - (44%)	Gaps:	169/982 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLKPAWV-HHDDK----QIFSVDIHKDCTKFATGGQGSDCGRVVIWNLLPV--LSDKAEFDAD 58
            |::.|..|: |.||:    .|||:.||.|.::.||||..   |.:.||:...:  .::....:.|
pombe     1 MKIKKIPWLGHFDDRGHRLSIFSIHIHPDGSRIATGGLD---GTIRIWSTEAINRENENENENED 62

  Fly    59 VPKMLCQMDQHLACVNCVRWSQNGQNLASGSDDKLIMIWRKS---AGSSGVFGTGGMQKNHESWK 120
            :||.||.|..|...|..||:|.|||.|||||||::::||.|.   .|....||:|  :|:.|:|:
pombe    63 LPKQLCCMSTHTGTVTSVRFSPNGQYLASGSDDRVVIIWHKEEAIPGLGSTFGSG--EKHTENWR 125

  Fly   121 CFYTLRGHDGDVLDLAWSPNDVYLASCSIDNTVIIWDAQAFPHSVATLKGHTGLVKGVSWDPLGR 185
            .:..|.|||.|:.||.||.:...:.|..:|:::|:|:...| ..:..::.|...|||:::||.|:
pombe   126 SYRRLLGHDNDIQDLCWSYDSQLVVSVGLDSSIIVWNGTTF-ERLKRIEAHQSHVKGITFDPAGK 189

  Fly   186 FLASQSDDRSIKIWNTMNWSLSHTITEPFEECGGTTHILRLSWSPDGQYLVSAHAMNGGGPTAQI 250
            :.|::||||:||:|...::|:..|||.||.....:|:..|.||||||:::.:.:||||......|
pombe   190 YFATESDDRTIKVWRVSDFSIEKTITGPFNNSPLSTYFRRPSWSPDGKHIAAPNAMNGPVSCVSI 254

  Fly   251 IEREGWKCDKDFVGHRKAVTCVRFHNSILSRQENDGSPSKPLQYCCLAVGSRDRSLSVWMTALQR 315
            |||..|..:.:.:||...|....| |..|.|.:||      ...|.||.|.:|||||:|.:||.|
pombe   255 IERGTWTSEINLIGHEGPVEVTAF-NPKLFRDKND------KLVCILACGGQDRSLSIWSSALPR 312

  Fly   316 PMVVIHELFNASILDLTWGPQECLLMACSVDGSIACLKFTEEELGKAISEEE-QNAIIRKMYGKN 379
            |::....:|..||.|:.|.|....|..||.||::....|.:||.|..:|:|| ..|:.:..:|::
pombe   313 PLLSCQNVFQKSIGDVCWSPDGLSLFLCSYDGNVLVCTFEKEEFGDMVSDEEISKALAKYGHGRH 377

  Fly   380 YVNGLGKSA----------PVLEHPQRL------LLPQGDK--------PTKFPL---------- 410
            .: .|.:||          .:|:.|..|      |:||...        |.|.|.
pombe   378 GI-VLPESAKQLELEETAYAILKKPSSLSTTDPTLVPQSSSTPKSAQKTPQKLPAFLPNRLTAET 441

  Fly   411 --SNNNEANQRPISK------------------QTETRTKDGKRRITPMFIPLHEDGPTS--LSM 453
              :|...|::..|:.                  |..|.||:||:|:.|..:......|::  |:.
pombe   442 VDTNKLTASKEQIASPKRPGPSDNGNEIPTKFVQKVTITKEGKKRVAPQLLTTLSATPSTSRLAS 506

  Fly   454 NIVSSSGSSTTALTSCSAAIGTLPAAAPTESAATPLMPLEPLVSKIDLGRLDSRLKTQPASQRRQ 518
            ..:..:|||.......|..|.:||      ....|::    :|..          ||:...:..:
pombe   507 TQLQHTGSSQLPPQQFSQPINSLP------KGGVPIL----IVGN----------KTKVNHENDE 551

  Fly   519 SLPFDPGQSNELLRTPRLEEHQS----STCSPSNLNVTATGKSEFVKAALD----YRLHVSNGHL 575
            |   |.....|.:....|:.:.|    |:.|.||:|..|......:..:|:    |.|.|.||
pombe   552 S---DQALQEEKIEEGLLKNYYSSLIDSSTSISNINFEAPRYKTNIVHSLNNEQKYVLEVKNG-- 611

  Fly   576 KTQHGMLAKVTASDSKEMLWEFYVGSPLVNLNLCEKYAMLCSLDGSMRLISMETGCPVFPAISLT 640
             |......::.|.::....|..|:..|::.:.....:..:...|||:.|.|: ||..:.|.|.:.
pombe   612 -TSEKNPTRIVALENGNTKWMDYLPRPVILVTGSIHFWSIACDDGSLHLYSL-TGSRLLPPIMIE 674

  Fly   641 SSA--VHCAFSPDNSLVGVLTECGLLRIWDIAKKVVSLAAGCL-ELLNK---------------H 687
            |.|  :||    :|:.:..::..|::..|::..|.....|..| .:|::               |
pombe   675 SKASFLHC----NNAYLLCISSSGMVYAWNVVNKTALFTANSLAPILSRVSNNVTIENNSTDIPH 735

  Fly   688 GTAAQFSVTNQGMPLIGFPSGNSYSYSTSL-------QSWLVLATKDAIMYHGIRGTLPRDMDQM 745
            ...|  |::.:|:|.:...:|.:|.||:::       :.|..:.:::    ....|.|..:....
pombe   736 VVIA--SISKEGVPSVTLSTGETYVYSSTMLCWQRITEPWWAIGSRE----WDSSGLLQSNTQTE 794

  Fly   746 QQKFPLLSMQASSQNYFSFTGSMELRHS-----------ESWQQCAKIRFIENQIKLCEALQSLD 799
            .|  ||...:..:.|....:|..:|...           :.::....|..:||:|.....|:..|
pombe   795 SQ--PLKIYEHRTNNVLMDSGRGKLLQKMVADAITEEGYDDFETIVTINHLENKIASARLLKLDD 857

  Fly   800 ELQHWHKMLTFQLATHGSEKRMRVFLDDLLSMPEPGIS----QFVPK-LELMQCVLDTLKPHSEW 859
            |.....::....|..||..:::..||.:|.:..:..|.    :.|.| |.:::..:.|.......
pombe   858 EFLVTSEVYVRLLMHHGLWQKLEEFLGELRTQTKCSIKLSGREVVAKMLVVLRQAVQTDNEFDRA 922

  Fly   860 NRLHSEY 866
            |:|..:|
pombe   923 NKLIEKY 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hira	NP_572401.2	WD40	<12..370	CDD:225201	139/367 (38%)
		WD40	14..349	CDD:238121	130/343 (38%)
		WD40 repeat	16..68	CDD:293791	19/53 (36%)
		WD40 repeat	74..127	CDD:293791	24/55 (44%)
		WD40 repeat	132..169	CDD:293791	9/36 (25%)
		WD40 repeat	176..211	CDD:293791	15/34 (44%)
		WD40 repeat	223..263	CDD:293791	16/39 (41%)
		WD40 repeat	275..322	CDD:293791	19/46 (41%)
		WD40 repeat	328..350	CDD:293791	9/21 (43%)
		HIRA_B	423..442	CDD:286531	8/36 (22%)
		Hira	629..820	CDD:284895	43/226 (19%)
hip1	NP_596575.1	WD40	15..348	CDD:238121	130/345 (38%)
		WD40	<15..348	CDD:225201	130/345 (38%)
		WD40 repeat	21..69	CDD:293791	17/50 (34%)
		WD40 repeat	78..132	CDD:293791	24/55 (44%)
		WD40 repeat	137..173	CDD:293791	9/36 (25%)
		WD40 repeat	180..215	CDD:293791	15/34 (44%)
		WD40 repeat	222..267	CDD:293791	17/44 (39%)
		WD40 repeat	275..322	CDD:293791	20/53 (38%)
		WD40 repeat	325..347	CDD:293791	9/21 (43%)
		HIRA_B	475..495	CDD:286531	8/19 (42%)
		Hira	663..878	CDD:284895	43/226 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0973
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I606
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003162
OrthoInspector	1	1.000	-	-		oto100531
orthoMCL	1	0.900	-	-		OOG6_103167
Panther	1	1.100	-	-	LDO	PTHR13831
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R561
SonicParanoid	1	1.000	-	-		X3052
TreeFam	1	0.960	-	-
	11	10.850