DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18155 and acsf3

DIOPT Version :9

Sequence 1:	NP_996360.2	Gene:	CG18155 / 31668	FlyBaseID:	FBgn0029945	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	XP_021329817.1	Gene:	acsf3 / 562292	ZFINID:	ZDB-GENE-121026-3	Length:	579	Species:	Danio rerio

Alignment Length:	572	Identity:	168/572 - (29%)
Similarity:	270/572 - (47%)	Gaps:	90/572 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VVPTFKKAMLYPDEIAVKDINGEYTYFQLYMAAKRLGIQISN--ICGGAAL--SNVTYLCSNNAL 106
            |.|.|.:|..|.|::|:.|.:|.:||..||..:|.|...|:.  .|....|  ..:::||:|:|.
Zfish    52 VAPVFSRAPAYGDKVAIMDHSGSHTYHSLYKNSKILAGHITKALTCQSGDLQGKRISFLCANDAS 116

  Fly   107 WIAIQWSCWISGQVAVPLESGQAIDQLQRQASNCKTKLLIATKEF----ESLAQELSQGVKSATI 167
            :...||:.|:.|.:||||.....:.:|:...|:.::.||:|.:.|    |.|||:|.
Zfish   117 YTVAQWASWMCGGIAVPLYRKHPLSELEYVISDSQSSLLVAGQSFVDTLEPLAQKLG-------- 173

  Fly   168 ILDHSFLPTAESVSSTSMYAKQLVAIQGVIVTENTFPNDF---YSKAPAMLIYTPNAVNSPKPVL 229
                  ||..:..:::|.:.           ...|.|.|.   :::.|||||||......||.||
Zfish   174 ------LPCLKLPATSSQFE-----------DTQTLPEDMISDWAERPAMLIYTSGTTGRPKGVL 221

  Fly   230 LTHRNIEAQMRCLIGTWHLGPTDCMLPILSMNRMHA---ALAAVLSVGGNVVLQQKFDGHNAWSA 291
            .||.:::|.::.|:..|.....|.:|..|.::.:|.   .|...|.||...::...|.....|..
Zfish   222 HTHSSLQAMVQGLVSEWAWHKDDVILHTLPLHHVHGIVNKLMCPLWVGATCIMLPDFSAQKVWEQ 286

  Fly   292 LLGINSPSKQRVTLFLAMPIVYKRLIVEYEKMFAKDSRMVEYIVNHCRQKIRLMATAFALLPDSV 356
            |:...||   .|.:|:|:|.:|.:||..|::.|.: .::.::|...|:::||||.:..|.||..|
Zfish   287 LICSKSP---MVNVFMAVPTIYSKLIEYYDQHFTQ-PQVQDFIRAVCKERIRLMVSGSAALPQPV 347

  Fly   357 FYRWREITGQNIYEYYGMMETGLVLGHPLNKRQRDSPHNGPTAVAMANNTAPNDYRPGTLGSPLK 421
            ..||.|||...:.|.|||.|.|:.|         .:.:.||..             ||.:|.||.
Zfish   348 LERWAEITDHVLLERYGMTEIGMAL---------SNSYKGPRV-------------PGAVGVPLP 390

  Fly   422 GVTARLISNKGDELITCKNELGGSVDSGLIPVEDIGGDASLAGTIIGELQIAGSNLVSNTLANNN 486
            ||..|::.| ...:|......|..|.:||...|             |||.:.||: |.....|..
Zfish   391 GVEVRIMMN-SSIVIAEGTSKGTQVKAGLEGKE-------------GELLVRGSS-VFQKYWNKP 440

  Fly   487 QEMEHKGTTNNEEQENNQDGFFKTGDICAYRNGNFYFLSKSS-DIFTVGGYKVYGSEIKKVLISH 550
            ||.|...|         :|.:|||||...||:|.::.:.::| ||...||||:...::::.|::|
Zfish   441 QETEESFT---------EDRWFKTGDTALYRDGVYWIMGRTSVDIIKSGGYKISALDVERHLLAH 496

  Fly   551 PNINDVAVLGIPNKMWGHRLGVICIVSPDADIDLDAIKTYCYRHLPAHKCPT 602
            |:|.||||:|.|:..||.::..:..:.....:.|..:|.:...|:.::..||
Zfish   497 PDITDVAVIGAPDATWGQKVTAVVQMRKGKTMILSDLKAWAREHMASYSIPT 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18155	NP_996360.2	CaiC	53..604	CDD:223395	165/565 (29%)
CG18155	NP_996360.2	AFD_class_I	58..607	CDD:302604	163/560 (29%)
acsf3	XP_021329817.1	MCS	64..566	CDD:213307	163/560 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594898
Domainoid	1	1.000	183	1.000	Domainoid score	I3365
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3331
OMA	1	1.010	-	-		QHG55233
OrthoDB	1	1.010	-	-		D229996at33208
OrthoFinder	1	1.000	-	-		FOG0002270
OrthoInspector	1	1.000	-	-		otm26394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24096
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R434
SonicParanoid	1	1.000	-	-		X2297
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.990