Protein Alignment unc-119 and UNC119

DIOPT Version :10

• Sequence 1: NP_572389.1
• Gene: unc-119 / 31664
• FlyBaseID: FBgn0025549
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_005139.1
• Gene: UNC119 / 9094
• HGNCID: 12565
• Length: 240
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 138/255 - (54%)
• Similarity: 171/255 - (67%)
• Gaps: 23/255 - (9%)

  Fly    11 VQSSGAGAVTTSSSAAAGSSSSNSGV---EANGGSGGSSGAAAAGAGASGDAKRPAESSSVTPDE 72
            |:..|.||.|.:.||...|..|.:.:   .|...||..|...|......|..:|   ...:.|::
Human     3 VKKGGGGAGTATESAPGPSGQSVAPIPQPPAESESGSESEPDAGPGPRPGPLQR---KQPIGPED 64

  Fly    73 VLHLTKITDDYLCSANANVFEIDFTRFKIRDLESGAVLFEIAKPP-SEQYPEGLSSDETMLAAAE 136
            ||.|.:||.|||||...|:::|||.||||||::||.|||||.||| ||:.|
Human    65 VLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLP-------------- 115

  Fly   137 KLSLDDTADPNAGRYVRYQFTPAFLNLKTVGATVEFTVGSQPLNNFRMIERHFFRDRLLKTFDFE 201
             ::..| .||||||:||||||||||.|:.||||||||||.:|:|||||||||:||::|||:|||.
Human   116 -INRRD-LDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFH 178

  Fly   202 FGFCFPFSKNTVEHIYEFPNLPPDLVAEMISSPFETRSDSFYFVGNRLVMHNKADYAYDG 261
            ||||.|.||||.||||:||.|..:|::|||..|:||:|||||||.:||||||||||:|.|
Human   179 FGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSG 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
unc-119	NP_572389.1	GMP_PDE_delta	89..259	CDD:428436	109/170 (64%)
UNC119	NP_005139.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..61		16/60 (27%)
		Required for midbody localization	1..59		16/58 (28%)
		GMP_PDE_delta	81..236	CDD:428436	109/170 (64%)
		Required for centrosome localization	121..240		87/118 (74%)