Protein Alignment Cph and BCL11B

DIOPT Version :10

• Sequence 1: NP_001356899.1
• Gene: Cph / 31660
• FlyBaseID: FBgn0029939
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_612808.1
• Gene: BCL11B / 64919
• HGNCID: 13222
• Length: 894
• Species: Homo sapiens
• Alignment Length: 1184
• Identity: 319/1184 - (26%)
• Similarity: 429/1184 - (36%)
• Gaps: 470/1184 - (39%)

  Fly    32 DILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNPQMDRDAEEGRPLSLVNRRPSISAP 96
            |:||||.||..|.|.||:.||:||..||. .:.|.|  .:..:|:|:.   |.|..:....:|.|
Human    54 DLLTCGQCQMNFPLGDILVFIEHKRKQCG-GSLGAC--YDKALDKDSP---PPSSRSELRKVSEP 112

  Fly    97 IS-GRKSAP-----------------ASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSPADL 143
            :. |.:..|                 .:.|.....|...|.|..||||....|.|.:|      |
Human   113 VEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPAVAPIAASSHPHSSVITSP------L 171

  Fly   144 LADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQDKQ 208
            .|.||  .|..|                         ..|....|..|||.:     |.:.|.:.
Human   172 RALGA--LPPCL-------------------------PLPCCSARPVSGDGT-----QGEGQTEA 204

  Fly   209 SQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTCSTC 273
            ....|.::..:                                           .|||:|.|:||
Human   205 PFGCQCQLSGK-------------------------------------------DEPSSYICTTC 226

  Fly   274 KTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLASPQP 338
            |..:.|||.|:||.|::||.:||:| ||                           .||...:|:.
Human   227 KQPFNSAWFLLQHAQNTHGFRIYLE-PG---------------------------PASSSLTPRL 263

  Fly   339 AVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQLQLQQQ 403
            .:.|            |||.          .:...:.|:|..|.|
Human   264 TIPP------------PLGP----------EAVAQSPLMNFLGDS-------------------- 286

  Fly   404 QAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMPLP-----PALAQAGNVV 463
                                                   |||.||||..|     |...:..  :
Human   287 ---------------------------------------NPFNLLRMTGPILRDHPGFGEGR--L 310

  Fly   464 PTVAPLFGRPSPADHYRMEQLVSEQFRHHGFNLAAAAAAAQAQFNANGQVVGGVVSGSGEPRPPS 528
            |...|||..|.               |||
Human   311 PGTPPLFSPPP---------------RHH------------------------------------ 324

  Fly   529 SSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQIT 593
                           |.|..||:             ::.|...|..||         ..:..::.
Human   325 ---------------LDPHRLSA-------------EEMGLVAQHPSA---------FDRVMRLN 352

  Fly   594 PGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTT------SPGAGS----TVNSSSPSPRQKQSPHF 648
            |         :.::...||| |:|||:|||.:      |||.|:    .:|...|||:   ||..
Human   353 P---------MAIDSPAMDF-SRRLRELAGNSSTPPPVSPGRGNPMHRLLNPFQPSPK---SPFL 404

  Fly   649 ASPS-PSQQQQQQLATIPRPHSLTPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEP 712
            ::|. |           |.|...|||.:                        ||:|:
Human   405 STPPLP-----------PMPPGGTPPPQ------------------------PPAKS-------- 426

  Fly   713 IAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQ 777
                .||.:|.|.|:|::|||:|:|:|||||||||..||..||...||.:||:.|...|.....:
Human   427 ----KSCEFCGKTFKFQSNLIVHRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGR 487

  Fly   778 DNQDDGSNADSLETNEADNDEDPNPDESE---EELGDGDND---PDGDGDLDGEDEDEDELEECE 836
              .|||.:|.|          .|.|..||   |.|...|.|   .:.|..|..|.|:|||.||.|
Human   488 --SDDGLSAAS----------SPEPGTSELAGEGLKAADGDFRHHESDPSLGHEPEEEDEEEEEE 540

  Fly   837 DMDYKAE-----------DLSVS-NRIDGKSQSPKTTSSGATS----------LVGELMDKFGLS 879
            :.:...|           |..:| ||.:|....|....:|..:          ::|::|:..||.
Human   541 EEELLLENESRPESSFSMDSELSRNRENGGGGVPGVPGAGGGAAKALADEKALVLGKVMENVGLG 605

  Fly   880 NIAQYSE--AYKQAL----------QESGRKEAAAAAAAAAAAADNNNRGGAGAPLSDKLNGL-- 930
            .:.||.|  |.||..          .::|..:.|.....|.|....|.|||..||.::...||
Human   606 ALPQYGELLADKQKRGAFLKRAAGGGDAGDDDDAGGCGDAGAGGAVNGRGGGFAPGTEPFPGLFP 670

  Fly   931 ----PV-------AALRLRDE---------FAKNCNMFQQPQDGGAPSQVPLFNPF-------PN 968
                |:       ||.|::.|         ...:.|::.|...|.|.|:..:.:||       .:
Human   671 RKPAPLPSPGLNSAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQS 735

  Fly   969 PFELSKRMKMDGGDWWGMSQALHRNEALFENLKLKP-LGLGGANSLIQGP----LLKKESRQRND 1028
            ||..|.....:.|   .:..:....:.|...|..:. ...||:...:.||    ...||.| |:|
Human   736 PFATSSEHSSENG---SLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGR-RSD 796

  Fly  1029 TCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDM 1093
            |||:|||||||||||||||||||||:|||||||:|||||||||||||||||:.||:||||..|.|
Human   797 TCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQM 861

  Fly  1094 PFSVPSTLEKHMRK 1107
            ||||.|||||||:|
Human   862 PFSVYSTLEKHMKK 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cph	NP_001356899.1	zf-C2H2	717..739	CDD:395048	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:463886	17/24 (71%)
		C2H2 Zn finger	747..767	CDD:275368	9/19 (47%)
		zf-C2H2	1029..1050	CDD:395048	19/20 (95%)
		C2H2 Zn finger	1030..1050	CDD:275368	18/19 (95%)
		zf-H2C2_2	1042..1067	CDD:463886	22/24 (92%)
		C2H2 Zn finger	1058..1078	CDD:275368	18/19 (95%)
		C2H2 Zn finger	1088..1106	CDD:275368	13/17 (76%)
BCL11B	NP_612808.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..428		23/107 (21%)
		zf-C2H2	428..449	CDD:395048	11/20 (55%)
		C2H2 Zn finger	429..449	CDD:275370	10/19 (53%)
		zf-H2C2_2	441..466	CDD:463886	17/24 (71%)
		C2H2 Zn finger	457..477	CDD:275370	9/19 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..583		35/123 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..680		8/26 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..794		12/60 (20%)
		zf-C2H2	797..818	CDD:395048	19/20 (95%)
		C2H2 Zn finger	798..818	CDD:275368	18/19 (95%)
		zf-H2C2_2	810..835	CDD:463886	22/24 (92%)
		C2H2 Zn finger	826..846	CDD:275368	18/19 (95%)
		C2H2 Zn finger	856..874	CDD:275368	13/17 (76%)