Protein Alignment Cph and Bcl11a

DIOPT Version :10

• Sequence 1: NP_001356899.1
• Gene: Cph / 31660
• FlyBaseID: FBgn0029939
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001178612.1
• Gene: Bcl11a / 305589
• RGDID: 1309923
• Length: 835
• Species: Rattus norvegicus
• Alignment Length: 1199
• Identity: 310/1199 - (25%)
• Similarity: 424/1199 - (35%)
• Gaps: 511/1199 - (42%)

  Fly    11 DHGFRSLSHSDSTENDAVATQDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNPQMD 75
            |||.......|         .|:||||.||..|.|.||:.||:||..|||    |...
  Rat    32 DHGPLGAPEGD---------HDLLTCGQCQMNFPLGDILIFIEHKRKQCN----GSLC------- 76

  Fly    76 RDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSP 140
              .|:|     |::.||                                             |||
  Rat    77 --LEKG-----VDKPPS---------------------------------------------PSP 89

  Fly   141 ADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQ 205
            .::   ..:|.|   |:.....||:|.:..:|                  |....|
  Rat    90 IEM---KKASNP---VEVGIQVTPEDDDCLST------------------SSRGIC--------- 121

  Fly   206 DKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTC 270
                 |||..:..:.....|::..::         ...:|...|.|....|.......|||:|||
  Rat   122 -----PKQEHIADKLLHWRGLSSPRS---------AHGALIPTPGMSAEYAPQGICKDEPSSYTC 172

  Fly   271 STCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLAS 335
            :|||..:||||.|:||.|::||::||:||..|
  Rat   173 TTCKQPFTSAWFLLQHAQNTHGLRIYLESEHG--------------------------------- 204

  Fly   336 PQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQLQL 400
                              |||                              |..:|.|
  Rat   205 ------------------SPL------------------------------TPRVGIP------- 214

  Fly   401 QQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHANPFQLLRMP---LPPALAQAGNV 462
                                 |.:.|.....|.|........|||.|||:|   ...|...|...
  Rat   215 ---------------------SGLGAECPSQPSLHGIPIADNNPFNLLRIPGSVSREASGLAEGR 258

  Fly   463 VPTVAPLFGRPSPADH---YRMEQLVSEQF---RHHGFNLAAAAAAAQAQFNANGQVVGGVVSGS 521
            .|...|||. |.|..|   :|:|:|.:|:.   .||
  Rat   259 FPPTPPLFS-PPPRHHLDPHRIERLGAEEMALATHH----------------------------- 293

  Fly   522 GEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQQQS 586
                               |:|.
  Rat   294 -------------------PSAF------------------------------------------ 297

  Fly   587 QQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSP--SPRQKQSPHFA 649
            .:..::.|         :.:||..||| |:|||:|||          |:|||  ||        .
  Rat   298 DRVLRLNP---------MAMEPPAMDF-SRRLRELAG----------NTSSPPLSP--------G 334

  Fly   650 SPSPSQQQQQQLATIPRPHSL-TPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQEPI 713
            .|||.|:..|......:|..| |||                  ..|..::.|||        :|.
  Rat   335 RPSPMQRLLQPFQPGSKPPFLATPP------------------LPPLQSAPPPS--------QPP 373

  Fly   714 AHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQDNQD 778
            ....||.:|.|.|:|::||::|:|:|||||||||..||..|:...||.:||:.|...:.....:
  Rat   374 VKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVK- 437

  Fly   779 NQDDG-SNADSLETNEAD-----------------NDEDPN--PDESEEELGDGDNDPDGDGDLD 823
             .||| |.|.|.|...:|                 ::.|||  |     |.||.:.:.|.:.:.:
  Rat   438 -SDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIP-----ENGDEEEEEDDEEEEE 496

  Fly   824 GEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVG-------ELMDKFGLSNI 881
            .|:|:|:||.|.|.:|| ...||:.     .::..:.:|.||...||       ::|....||::
  Rat   497 EEEEEEEELTESERVDY-GFGLSLE-----AARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSM 555

  Fly   882 AQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSD-KLNGLPVAALRLRDEFAKNC 945
            ..:|||:.|.|.|..::...|.|.......|.::..|....:.| .:||             :.|
  Rat   556 QHFSEAFHQVLGEKHKRSHLAEAEGHRDTCDEDSVAGESDRIDDGTVNG-------------RGC 607

  Fly   946 NMFQQPQDG-------GAPSQVPLFNPFPNPFELSKRMKMDG----------------GDW---W 984
            :..:....|       |:||.:       :||  |||:|::.                ..|   :
  Rat   608 SPGESASGGLSKKLLLGSPSSL-------SPF--SKRIKLEKEFDLPPAAMPNTENVYSQWLAGY 663

  Fly   985 GMSQALHRNEALFENLKLKPL--------------------------------GLGGANSLIQGP 1017
            ..|:.|......|.:.:..|.                                |.||:...|.||
  Rat   664 AASRQLKDPFLTFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGP 728

  Fly  1018 ----LLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHMKTH 1078
                ...||.| |:||||:|||||||||||||||||||||:|||||||:||||||||||||||||
  Rat   729 GPGRPSSKEGR-RSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTH 792

  Fly  1079 GRTGKDVYRCRFCDMPFSVPSTLEKHMRK 1107
            |:.|||||:|..|.|||||.|||||||:|
  Rat   793 GQVGKDVYKCEICKMPFSVYSTLEKHMKK 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cph	NP_001356899.1	zf-C2H2	717..739	CDD:395048	10/21 (48%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		zf-H2C2_2	731..756	CDD:463886	16/24 (67%)
		C2H2 Zn finger	747..767	CDD:275368	8/19 (42%)
		zf-C2H2	1029..1050	CDD:395048	19/20 (95%)
		C2H2 Zn finger	1030..1050	CDD:275368	18/19 (95%)
		zf-H2C2_2	1042..1067	CDD:463886	22/24 (92%)
		C2H2 Zn finger	1058..1078	CDD:275368	18/19 (95%)
		C2H2 Zn finger	1088..1106	CDD:275368	13/17 (76%)
Bcl11a	NP_001178612.1	zf-C2H2	378..399	CDD:395048	10/20 (50%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
		zf-H2C2_2	391..416	CDD:463886	16/24 (67%)
		C2H2 Zn finger	407..427	CDD:275368	8/19 (42%)
		zf-C2H2	743..764	CDD:395048	19/20 (95%)
		C2H2 Zn finger	744..764	CDD:275368	18/19 (95%)
		zf-H2C2_2	756..781	CDD:463886	22/24 (92%)
		C2H2 Zn finger	772..792	CDD:275368	18/19 (95%)
		C2H2 Zn finger	802..820	CDD:275368	13/17 (76%)