Protein Alignment Cph and Cph

DIOPT Version :10

• Sequence 1: NP_001356899.1
• Gene: Cph / 31660
• FlyBaseID: FBgn0029939
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: XP_061499017.1
• Gene: Cph / 1273357
• VectorBaseID: AGAMI1_000791
• Length: 1245
• Species: Anopheles gambiae
• Alignment Length: 1354
• Identity: 590/1354 - (43%)
• Similarity: 718/1354 - (53%)
• Gaps: 304/1354 - (22%)

  Fly     5 MLSISEDHGFRS--LSHSDSTENDAVATQDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQC 67
            |||.|||.||.|  ..||::.|:|. .||||||||:|||.|||||||:||||||.||||||||||
Mosquito     1 MLSTSEDAGFYSHNRDHSEAGESDG-TTQDILTCGSCQKTFALSDIVRFIQHKVFQCNKENYGQC 64

  Fly    68 ATQ-NPQMDRDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGS 131
            .|| ....|||:::||.|.|.....||:   :.|.|.|.      .:..|.......||:|.. .
Mosquito    65 FTQAGGGTDRDSDDGRRLLLTGNTSSIA---TRRASMPN------VSCRAGKQTITTASATYD-D 119

  Fly   132 RIHTPPP-SPADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSS 195
            |:||||| |||:||.||||||||...||.:|.:......||:.|                    .
Mosquito   120 RVHTPPPTSPAELLRDGASSTPKHPGDEPENASTHCPSRGASPL--------------------G 164

  Fly   196 CEMEEQQDRQDKQSQPKQAKVKQEPYD--------EEGVNHHQNQDDDDDEEMEERSLAKRPKME 252
            |.:::  |.:|::...:..::|||..|        ||.|:..:.|         .:::|...:..
Mosquito   165 CTLDD--DHRDQKPSVRAIEIKQERMDIDPASCGEEEFVSVRKQQ---------PQTVATAHRNG 218

  Fly   253 LVDAEANTVHTEPSNYTCSTCKTRYTSAWRLIQHVQHSHGVKIYVES-------PGGGATLT--- 307
            ..||..:..|||||||.||||||:|.|||||:|||||:|||||||||       .|.||..|
Mosquito   219 SHDASESPNHTEPSNYVCSTCKTKYHSAWRLVQHVQHAHGVKIYVESLASTGSQDGDGAAPTEES 283

  Fly   308 -------------------VATPAALNNSALALAAAAAAASASGLASP--------QPAVSPNPA 345
                               .|.|||...:....|.|....|.|...||        ||..||.|.
Mosquito   284 DAPESAAASEAANNGPSTGEAVPAAQKRTDEQPARARTPRSRSASRSPKAVSIEREQPIRSPAPK 348

  Fly   346 VTS-----SAKRSSPLGAAGST----------ILSTSVSSTCSNSLVN---------TSGGSISN 386
            ..|     ::|.:|..|.:|.:          ...||.||..|::.||         ||...::.
Mosquito   349 DRSNGLEVASKAASENGRSGESDDELEVRTKRPKLTSSSSNGSHATVNHTEEVALALTSPQPLTQ 413

  Fly   387 TSSIGSPQQQQ------LQLQQQQAQQQQQRVQQQQRENLASAMAAGMR--------------HH 431
            |::..:.||:|      |.:...|:..:.|.......|.:|:...|..|              ||
Mosquito   414 TAATTTTQQRQSSTPQPLTVSSVQSPSRPQHSPPAGSETIAAPSLAPARSESTQSLPPPSLRPHH 478

  Fly   432 PLLPPPEAMHANPFQLLRMPLPPALAQAGNVVP--TVAPLFGRPSPADH-YRMEQLVSEQFRHHG 493
            .|||||| :|.|||.|||||            |  ..:|||||   ..| :|||.|:|||||.||
Mosquito   479 SLLPPPE-LHQNPFGLLRMP------------PHHPHSPLFGR---THHDFRMEHLMSEQFRSHG 527

  Fly   494 FNLAAAAAAAQAQFNANGQVVGGVVSGSGEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQ 558
            .||||||.||..|..::||........:...||||:.::.|        ||
Mosquito   528 LNLAAAAVAAANQLKSHGQQFNPATGATASERPPSAGAATS--------AL-------------- 570

  Fly   559 QAVQQQQQQGAQQQLQSAQQQQQSQQQSQQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAG 623
                                            .:||| .||||....||| .||:||||||||||
Mosquito   571 --------------------------------TLTPG-GGGAGVVGGLEP-HMDYYSQRLRQLAG 601

  Fly   624 TTSPGAGST-VNSSSPSPR-QKQSP-HFASPSPSQQ-QQQQLATIPRPHSLTPPEK-----LG-D 678
            ||||||..| .:|:||||| |..|| ||||||||.| ....|....||.|||||||     || |
Mosquito   602 TTSPGANLTSASSNSPSPRKQPHSPSHFASPSPSHQLPPTPLTNNSRPQSLTPPEKHTEQLLGLD 666

  Fly   679 ASSENGSLGLILASTPRSASTPPSKTGDVSLQEPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEK 743
            |.|        :::|||||||||:|....|..:  :..|||.||.|||||::||::|:||||.|.
Mosquito   667 AGS--------ISNTPRSASTPPNKQSGQSASD--SALYSCEYCGKKFRFQSNLLVHRRTHTAEL 721

  Fly   744 PYKCTACDFECSHIQKLMKHMR-VHRSPADDQDNQDNQDDG-SNADSLETNEADNDEDPNPDESE 806
            ||||.:|:|.|....||.:||: ||.............|.| ||.||:|:         :||:::
Mosquito   722 PYKCASCEFACGQAAKLKQHMKLVHGRRRTSVAAMSEPDSGTSNVDSIES---------DPDDTD 777

  Fly   807 EELGDGDN-DPDGDGD----------LDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKT 860
            .||.|.|. |.||:.|          .||||::|||.|:.::.|.:|||||:|:.   :|||.|.
Mosquito   778 HELMDADELDADGEADRRTAHGDDEHADGEDDEEDEDEDEDEEDDEAEDLSMSST---QSQSKKD 839

  Fly   861 TSSG----ATSLVGELMDKFGLSNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGA 921
            .|.|    :|||||||||||||||||||||||||||||||.   |......:...||||...|..
Mosquito   840 GSGGSMSMSTSLVGELMDKFGLSNIAQYSEAYKQALQESGN---ALKLQLTSKDRDNNNSAMAIP 901

  Fly   922 PLSDKLNGLPVAALRLRDEFAKNCNMFQQPQDGGAPSQVPLFNPFPNPFELSKRMKMDGGD-WWG 985
            .|::|||||| ||||:::|.|||   ..|..:...| ||||||||.||||.|||||::|.| |||
Mosquito   902 GLAEKLNGLP-AALRIKEELAKN---MLQHHNAQLP-QVPLFNPFENPFEASKRMKLEGSDSWWG 961

  Fly   986 MSQALHRNEALFENLKL-KPLGLGGANSLIQGPLLKKESRQRNDTCEFCGKVFKNCSNLTVHRRS 1049
            : ..:||.:|||||||. :..|.|.|..|:| |::||||:.||||||||||||||||||||||||
Mosquito   962 L-PGMHRGDALFENLKPGRDGGRGPAAGLLQ-PMMKKESKLRNDTCEFCGKVFKNCSNLTVHRRS 1024

  Fly  1050 HTGEKPYKCELCSYACAQSSKLTRHMKTHGRTGKDVYRCRFCDMPFSVPSTLEKHMRKCVVNQGK 1114
            |||||||||||||||||||||||||||||||.||||||||||:||||||||||||||||||||||
Mosquito  1025 HTGEKPYKCELCSYACAQSSKLTRHMKTHGRLGKDVYRCRFCEMPFSVPSTLEKHMRKCVVNQGK 1089

  Fly  1115 AAAAANAVAAAQAAQAAAQHIQAAAQQAQAVQAQAVQAQAAQQSQQQQQQLSPMGVVGYPPQFVS 1179
                            ..|..|...||.|..:.|..|..|||| |||||||:...:.      ::
Mosquito  1090 ----------------LQQQQQRELQQLQQRELQHHQQLAAQQ-QQQQQQLAAQQMA------LA 1131

  Fly  1180 GHNLSLPGSVSGDNDSNASSSMT--GVHPISLKEEAXLFSGFPVPLAP--PPPL 1229
            .|.      ..||:....|....  ..|..:.:..| ..:..|||.||  ||.|
Mosquito  1132 AHR------DRGDHHRERSRERDHHHHHHHAAQTLAAAAAASPVPGAPQLPPGL 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cph	NP_001356899.1	zf-C2H2	717..739	CDD:395048	14/21 (67%)
		C2H2 Zn finger	719..739	CDD:275368	12/19 (63%)
		zf-H2C2_2	731..756	CDD:463886	15/24 (63%)
		C2H2 Zn finger	747..767	CDD:275368	8/20 (40%)
		zf-C2H2	1029..1050	CDD:395048	20/20 (100%)
		C2H2 Zn finger	1030..1050	CDD:275368	19/19 (100%)
		zf-H2C2_2	1042..1067	CDD:463886	24/24 (100%)
		C2H2 Zn finger	1058..1078	CDD:275368	19/19 (100%)
		C2H2 Zn finger	1088..1106	CDD:275368	16/17 (94%)
Cph	XP_061499017.1	None