Protein Alignment xit and ALG8

DIOPT Version :10

• Sequence 1: NP_572355.1
• Gene: xit / 31623
• FlyBaseID: FBgn0029906
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001412153.1
• Gene: ALG8 / 79053
• HGNCID: 23161
• Length: 557
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 259/569 - (45%)
• Similarity: 335/569 - (58%)
• Gaps: 87/569 - (15%)

  Fly    11 IATG--------------LKILLIPAYHSTDFEVHRNWLAITHSLPLNQWYVDATSEWTLDYPPF 61
            ||||              ||.||||.||||||||||||||||||||::|||.:||||||||||||
Human     6 IATGTGNWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHSLPISQWYYEATSEWTLDYPPF 70

  Fly    62 FAYFEWLLSQVAKYVDPRMLVVDNLNYESKATVYFQRLSVIVTDLVYVLGVR---SCLGSLGLGR 123
            ||:||::||.||||.|..||.|.||||.|..|:.|||.|||..|:::|..||   .|:....:|:
Human    71 FAWFEYILSHVAKYFDQEMLNVHNLNYSSSRTLLFQRFSVIFMDVLFVYAVRECCKCIDGKKVGK 135

  Fly   124 DTQQ--FFAASMLLLLNVGLIFVDHIHFQYNGLLFGILLLSIGSL-------------------- 166
            :..:  .|..|:|||.|.||:.||||||||||.|||::||||..|
Human   136 ELTEKPKFILSVLLLWNFGLLIVDHIHFQYNGFLFGLMLLSIARLFQRQGLPILSRLVLNSWGQA 200

  Fly   167 -----------IRQRFLWSAFAFAVLLNFKHIFLYMAPAFGVYLLRFYCL----EQASVVSAVGA 216
                       :::|.:..||.|||||:||||:||:|||:||||||.||.    ...|:.....:
Human   201 ILPRRLTKVLGLQKRHMEGAFLFAVLLHFKHIYLYVAPAYGVYLLRSYCFTANKPDGSIRWKSFS 265

  Fly   217 VVKLLVVGLTPF---AVSFGPF--WQQLPQVLSRLFPFKRGLTHAYWAPNFWALYNAADKLAAGV 276
            .|:::.:||..|   |:|.|||  ..|||||.||||||||||.||||||||||||||.||:.:.:
Human   266 FVRVISLGLVVFLVSALSLGPFLALNQLPQVFSRLFPFKRGLCHAYWAPNFWALYNALDKVLSVI 330

  Fly   277 ---LKVQDGG----ASTTSGLVQEVRHSVLPAITPPVTFALTALFMLPILVKLFRSAKKQSPLVF 334
               ||..|..    ||.||||||:.:|:|||::||..|...|.:.:||.:..|:  .|.|.|..|
Human   331 GLKLKFLDPNNIPKASMTSGLVQQFQHTVLPSVTPLATLICTLIAILPSIFCLW--FKPQGPRGF 393

  Fly   335 LRAVVLCGCSSFVFGWHVHEKAILMVLLPLCLLTLVNREDARYAYVLGIAGYFSLFPLLFDADLY 399
            ||.:.||..|||:|||||||||||:.:||:.||::....||....:|...|::|||||||.|...
Human   394 LRCLTLCALSSFMFGWHVHEKAILLAILPMSLLSVGKAGDASIFLILTTTGHYSLFPLLFTAPEL 458

  Fly   400 IPRYSLYMSYVAMMYGQLYRIFPGFRG-FHTLEWLYMLGFMAIPLYEHLLSFLLHLDQ---RLPF 460
            ..:..|.:.:.......|..:|...:. |:.:|..|:||..  || |....|:.....   :.||
Human   459 PIKILLMLLFTIYSISSLKTLFRKEKPLFNWMETFYLLGLG--PL-EVCCEFVFPFTSWKVKYPF 520

  Fly   461 LPLLLTSVYSALGVLYFFGAYYLYALGISWGKVPIASSTSAAAVKRKRK 509
            :||||||||.|:|:.|            :|.|:.::....:|..|.|::
Human   521 IPLLLTSVYCAVGITY------------AWFKLYVSVLIDSAIGKTKKQ 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
xit	NP_572355.1	Alg6_Alg8	12..481	CDD:460831	253/538 (47%)
ALG8	NP_001412153.1	Alg6_Alg8	21..541	CDD:460831	251/536 (47%)