DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment xit and Alg8

DIOPT Version :9

Sequence 1:	NP_572355.1	Gene:	xit / 31623	FlyBaseID:	FBgn0029906	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001029299.1	Gene:	Alg8 / 293129	RGDID:	1305468	Length:	526	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	259/540 - (47%)
Similarity:	331/540 - (61%)	Gaps:	60/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GIATG--------------LKILLIPAYHSTDFEVHRNWLAITHSLPLNQWYVDATSEWTLDYPP 60
            |:|.|              ||.||||.|||||||||||||||||:||::|||.:|||||||||||
  Rat     5 GLAAGSGHWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHNLPISQWYYEATSEWTLDYPP 69

  Fly    61 FFAYFEWLLSQVAKYVDPRMLVVDNLNYESKATVYFQRLSVIVTDLVYVLGVR---SCLGSLGLG 122
            |||:||:.||.:|||.|..||.:.||||.|..|:.|||.|||:||.::|..|.   .|:.....|
  Rat    70 FFAWFEYALSHIAKYFDQEMLDIHNLNYYSSRTLLFQRFSVILTDALFVYAVHECCKCIDGKRTG 134

  Fly   123 RDTQQ--FFAASMLLLLNVGLIFVDHIHFQYNGLLFGILLLSIGSLIRQRFLWSAFAFAVLLNFK 185
            :|..:  .|..|:|||.|.||:.||||||||||||.|:|||||..|.::|.:..||.|||||:||
  Rat   135 KDPTEKPKFVLSVLLLWNFGLLIVDHIHFQYNGLLSGLLLLSIARLFQKRHIEGAFLFAVLLHFK 199

  Fly   186 HIFLYMAPAFGVYLLRFYCLEQASVVSAVG----AVVKLLVVGLTPF---AVSFGPF--WQQLPQ 241
            ||:||:|||:|:||||.||...:....:|.    ::|::..:.|..|   |:|.|||  ..||||
  Rat   200 HIYLYVAPAYGIYLLRSYCFTASKPDGSVRWDSFSIVRVTALALIVFLVSALSLGPFLALNQLPQ 264

  Fly   242 VLSRLFPFKRGLTHAYWAPNFWALYNAADK--LAAGV-LKVQDGG----ASTTSGLVQEVRHSVL 299
            |.||||||||||.||||||||||||:|.||  ...|: ||:.|..    ||.||||||:.:|:||
  Rat   265 VFSRLFPFKRGLCHAYWAPNFWALYSALDKALCVTGLELKLLDPSQIPRASMTSGLVQQSQHTVL 329

  Fly   300 PAITPPVTFALTALFMLPILVKLFRSAKKQSPLVFLRAVVLCGCSSFVFGWHVHEKAILMVLLPL 364
            |:::|..|...|.:.:||.:..|:  .|.|.|..|||.:|||..|||:|||||||||||:.:||:
  Rat   330 PSVSPSATLICTLIAILPSVFCLW--FKPQGPRGFLRCLVLCALSSFMFGWHVHEKAILLAILPM 392

  Fly   365 CLLTLVNREDARYAYVLGIAGYFSLFPLLFDA---DLYIPRYSLYMSYVAMMYGQLYRIFPGFRG 426
            .||.:....||....:|...|::|||||||.|   .:.|...||:..|.......|:|.....
  Rat   393 SLLAVEKAGDATIFLILTTTGHYSLFPLLFTAPELPIKILLMSLFTVYSISSLRTLFRKEKPL-- 455

  Fly   427 FHTLEWLYMLGFMAIPLYEHLLSFLLHLDQ---RLPFLPLLLTSVYSALGVLYFFGAYYLYALGI 488
            |:.:|.||:||..  || |....||.....   :.||:||||||||.|:|:.|
  Rat   456 FNWMETLYLLGLG--PL-EVCCEFLFPFTSWKLKYPFIPLLLTSVYCAVGITY------------ 505

  Fly   489 SWGKVPIASSTSAAAVKRKR 508
            :|.::..:..|.....|.|:
  Rat   506 AWIRLYASVLTGCLVSKTKK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xit	NP_572355.1	Alg6_Alg8	12..478	CDD:281190	254/506 (50%)
Alg8	NP_001029299.1	Alg6_Alg8	22..507	CDD:397324	252/503 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341424
Domainoid	1	1.000	439	1.000	Domainoid score	I536
eggNOG	1	0.900	-	-		E1_KOG2576
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6931
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1621
OMA	1	1.010	-	-		QHG55587
OrthoDB	1	1.010	-	-		D379099at33208
OrthoFinder	1	1.000	-	-		FOG0004662
OrthoInspector	1	1.000	-	-		oto98396
orthoMCL	1	0.900	-	-		OOG6_103222
Panther	1	1.100	-	-	LDO	PTHR12413
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810