DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14439 and Spns1

DIOPT Version :9

Sequence 1:	NP_001188550.1	Gene:	CG14439 / 31614	FlyBaseID:	FBgn0029898	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001034297.2	Gene:	Spns1 / 361648	RGDID:	1305613	Length:	528	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	117/549 - (21%)
Similarity:	205/549 - (37%)	Gaps:	149/549 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ELDYGD-HACQQNTSMFNRHELPTQCSAVMNETSCYALDFNGTGYCE-WNYNGLGID----YQIL 102
            ||:..| ...|:.|.:...|      |.::....||   .|...|.: :...|:..|    :.|.
  Rat    38 ELEVPDCEGLQRITGLSRGH------STLIVVVLCY---INLLNYMDRFTVAGVLTDIEQFFNIG 93

  Fly   103 AGPT------FILIFTIAGVFMGFAADKYNRVNMLTVCTVIFGIAMILQGTV----KEYWQLVIL 157
            .|.|      ||..:.:.....|:..|:|||..::  |..|...:::..|:.    :.:|.|::.
  Rat    94 DGSTGLIQTVFISSYMVLAPVFGYLGDRYNRKYLM--CGGIAFWSLVTLGSSFIPREHFWLLLLT 156

  Fly   158 RMIMAAGESGCNPLATGIMSDIFPEDKRALVMAIFNWGIYGGYGIAFPVGRYITKL-NFWNLGWR 221
            |.::..||:..:.:|..:::|:|..|:|:.:::||.:.|..|.|:.:..|..:..| ..|:...|
  Rat   157 RGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDLAGDWHWALR 221

  Fly   222 VCYLGAGVLTVIMAALTGTTLREPERKAIGEGDRQTSSG--KPVSLWQVIK----NPAMIMLMIA 280
            |. .|.|||.|::..|   .::||.|.|:   :|.:.|.  .|.|.|..:|    ||:.::..:
  Rat   222 VT-PGLGVLAVLLLFL---VVQEPPRGAV---ERHSGSPPLSPTSWWADLKALARNPSFVLSSL- 278

  Fly   281 ASIRHCGGMTFAYNADLYYNTYFPDVDLGWW------------------------------LFG- 314
                   |.|         ...|....|..|                              :||
  Rat   279 -------GFT---------AVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGL 327

  Fly   315 VTIGIGSVGVVVGGIVS----------DKIVAKMGIRSRAFVLAVSQLIATLPAFGSVYFDPLWA 369
            :|...|.:||.:|..:|          |.:|...|:...:..|.:|...|.    ||:
  Rat   328 ITCLTGVLGVGLGVEISRRLRRFNPRADPLVCAAGLLGSSPFLFLSLACAR----GSI------- 381

  Fly   370 MITLGLSYFFAEMWFGIVFAIVVEI---VPLRVRSSTIGVFLFVMNNIGGNL--PILVD------ 423
             :...:..|..|....:.:|||.:|   |.:..|.||...|..|::::.|:.  |.|:.
  Rat   382 -VATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRL 445

  Fly   424 ----PVAKILGYRG---SIMIFYAGFYG-ISSILFFITCFLLEGKPDEVGQPESPKSHPDAVLNA 480
                |.:.:..:|.   |:|:  ..|.| :....|..|...:|.               |.....
  Rat   446 RRSWPPSFLSEFRALQFSLML--CAFVGALGGAAFLGTAMFIEN---------------DRRRAQ 493

  Fly   481 RHMHG--HDNSVFSVDETLPSNGRPAQLP 507
            .|:.|  |:.........:|..||..::|
  Rat   494 LHVQGLLHETEPSDDQIVVPQRGRSTRVP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14439	NP_001188550.1	MFS_1	94..416	CDD:284993	86/386 (22%)
CG14439	NP_001188550.1	MFS	107..452	CDD:119392	91/415 (22%)
Spns1	NP_001034297.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		117/549 (21%)
		MFS	62..450	CDD:119392	93/428 (22%)
		MFS_1	65..418	CDD:284993	87/393 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810