DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc7 and RPS6KA6

DIOPT Version :9

Sequence 1:	NP_727103.1	Gene:	Cdc7 / 31598	FlyBaseID:	FBgn0028360	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_016884912.1	Gene:	RPS6KA6 / 27330	HGNCID:	10435	Length:	762	Species:	Homo sapiens

Alignment Length:	740	Identity:	137/740 - (18%)
Similarity:	240/740 - (32%)	Gaps:	261/740 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 VMGLPATPRTTKQARNKSEEAINDLLTRI--PDIGKLFDVHSRIGNGTFSTVLLGTLRRES-HLP 153
            |..:|.| ...|:...|::.|..:||..:  ...||:|.|..:.|........:..|::.| .:.
Human    69 VKEIPIT-HHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVR 132

  Fly   154 DSLRRKFAIKHHIPTSHPDRIMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFMAHDRFQDF 218
            |.:|.|......:..:||                 .:|.:|...:.:.....::.|:   |..|.
Human   133 DRVRTKMERDILVEVNHP-----------------FIVKLHYAFQTEGKLYLILDFL---RGGDV 177

  Fly   219 YTRMD------VPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLYNRRRREFLLVDFGLAQHVN 277
            :||:.      ..:::.|:..|.:||.|:|:..:::||:||.|.|.: ......|.||||
Human   178 FTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHIKLTDFGL----- 236

  Fly   278 PPAARSSGSAAAIAAANNKNNNNNNNNNSKRPRERESK-----GDVQQIALDAGLGGAVKRMRLH 337
                                        ||...::|.|     |.|:.:|.:      |...|.|
Human   237 ----------------------------SKESVDQEKKAYSFCGTVEYMAPE------VVNRRGH 267

  Fly   338 EES------NKMPLKPVNDIAPSDAPEQSVDGSNHV------QPQLVQQEQQQLQPQQQQQQQQQ 390
            .:|      ..:..:.:....|....::: :..|.:      .||.:..|.|.|.....::....
Human   268 SQSADWWSYGVLMFEMLTGTLPFQGKDRN-ETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPAN 331

  Fly   391 QQQSQQQQQPQQQ------------SQQQHPQRQPQLAQMDQ--------TASTPSGS------- 428
            :..|:..::.::.            .::..|..:|...:.|.        ||.||..|
Human   332 RLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASA 396

  Fly   429 ------------------KYN----TNRNVSAAAANNAKCVCF------------ANPSVCLNCL 459
                              :|.    |:.||......|.....|            .:.|||..|
Human   397 NAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRC- 460

  Fly   460 MKKEVHAS-------RAGTPGYRPP----EVLLKY---PDQTTAVDVWAAG-------------- 496
                :||:       :......|.|    |:|::|   |:..|..||:..|
Human   461 ----IHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGE 521

  Fly   497 --------------------------VIFLSIMSTVYPFFKAPN----DFIALAEIVTI--FGDQ 529
                                      |.:|.....|:...|..|    |..|.|:.:.|  ||
Human   522 LLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFG-- 584

  Fly   530 AIRKTALALDRMITLSQRSRPLNLRKLCLRFRYRSVFSDAKLLKSYESVDGSCEVCRNCDQYFFN 594
                          .:::.|..|  .|.|...|.:.|...::|.. :..|.:|::. :....|:.
Human   585 --------------FAKQLRGEN--GLLLTPCYTANFVAPEVLMQ-QGYDAACDIW-SLGVLFYT 631

  Fly   595 CLCEDSDYLTEPLDA-------------------YECFPPSAYDLLDRLLEINPHKRITAEEALK 640
            .|...:.:...|.|.                   ::.....|.|||..:|.::||:|.|||:.||
Human   632 MLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILK 696

  Fly   641 HPFFTAAEEAEQTEQDQLANGTPRK 665
            |.:.        |.:|||.|..|::
Human   697 HSWI--------THRDQLPNDQPKR 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc7	NP_727103.1	STKc_Cdc7	125..644	CDD:270921	122/682 (18%)
		PKc_like	<474..644	CDD:304357	48/241 (20%)
		PKc_like	<616..675	CDD:304357	20/50 (40%)
RPS6KA6	XP_016884912.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910