DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc7 and speg

DIOPT Version :9

Sequence 1:	NP_727103.1	Gene:	Cdc7 / 31598	FlyBaseID:	FBgn0028360	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_031748703.1	Gene:	speg / 100486621	XenbaseID:	XB-GENE-984260	Length:	3808	Species:	Xenopus tropicalis

Alignment Length:	534	Identity:	88/534 - (16%)
Similarity:	157/534 - (29%)	Gaps:	194/534 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 TKQARNKSEE------------------AINDL-LTRIPDIGKLFDVHSRIGNGTFSTVLLGTLR 147
            |..|||.|.|                  ||.:: :.::..:...:::|..||.|.||.|
Frog  1598 TCTARNLSGEISCKAELQVCPDEPGAGSAIQEIDILKVRRLTDFYNIHKEIGRGAFSYV------ 1656

  Fly   148 RESHLPDSLRRKFAIKHHIPTSHPDR--IMKELQCMTKMGGKENVVGIHCCMRYDASAAFVMPFM 210
              .|:.:....:......||.....|  ..:|...::|: ..:.::..:......::...||...
Frog  1657 --RHVVEKSNGRDLAAKFIPFRGATRESARRERDILSKL-RHDRIIFFYDAFEKRSALIIVMELC 1718

  Fly   211 AHDRFQDFYTR---MDVPEIRQYMRNLLVALRHVHKFDVIHRDVKPSNFLY-NRRRREFLLVDFG 271
            :.:...:..||   :...|||.::|.:|..|.::|..:::|.|:||.|.|. :....:..:.|||
Frog  1719 SQEELLERLTRKPTVSESEIRSFIRQILEGLDYLHHKNILHLDIKPENILMADTTSEQIRICDFG 1783

  Fly   272 LAQHVNP--PAARSSGSAAAIA--------------------------------AANNKNNNNNN 302
            .||.:.|  |.....|:...:|                                ...|......|
Frog  1784 NAQELTPGDPQYCKYGTPEFVAPEIVNQMPISTVTDIWPVGVLAYLCLTGVSPFVGENDYTTLMN 1848

  Fly   303 ----------------------------NNNSKRPRERESKGDVQQIALDAGLGGAVKRMRLHEE 339
                                        .|...||...||........|..|...:...::|.:.
Frog  1849 IRGYTVAFEEKMFVGLTREARGFLIKVLGNEKLRPNAEESLEHPWFKTLAKGKSISTDHLKLFQS 1913

  Fly   340 SNKMPLKPV---NDIAPSDAPEQSVDGSNHV------------------------------QPQL 371
            ..|.....:   :::.....||...|.|||:                              .|..
Frog  1914 RRKWQRSLISYKSNMVMRTIPELLQDTSNHLSIAVPKNSKEASGLSSSSDSDDLEELPFVPMPLQ 1978

  Fly   372 VQ-------------QEQQQLQPQQQ--------------------QQQQQQQQQSQQQQQP--- 400
            ||             .|:|..|||..                    ::|..||:::..|..|
Frog  1979 VQFSGSRMSLNEIPTDEEQLSQPQDNGSCREDEEEGSQAVEISSTFKEQAVQQKEATVQASPLSK 2043

  Fly   401 ----------------------QQQSQQQHPQRQPQLAQMDQTASTPSGSKYNTNRNVSAAAANN 443
                                  .:..:::||:|..:.....::|..|.|       .:.||....
Frog  2044 HAKGTLTRNRSAEVGSSSDEETSETEKREHPRRPLKKGSSLESADVPDG-------EIKAARRGE 2101

  Fly   444 AKCVCFANPSVCLN 457
            .:....|:.::.||
Frog  2102 LRRGSSADSALLLN 2115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc7	NP_727103.1	STKc_Cdc7	125..644	CDD:270921	80/492 (16%)
		PKc_like	<474..644	CDD:304357
		PKc_like	<616..675	CDD:304357
speg	XP_031748703.1	Ig strand A	910..912	CDD:409353
		Ig strand A'	915..920	CDD:409353
		Ig strand B	925..934	CDD:409353
		Ig strand C	940..945	CDD:409353
		Ig strand C'	948..950	CDD:409353
		Ig strand D	956..961	CDD:409353
		Ig strand E	965..971	CDD:409353
		Ig strand F	979..987	CDD:409353
		Ig strand G	990..1000	CDD:409353
		Ig	1014..1099	CDD:416386
		Ig strand A'	1017..1020	CDD:409353
		Ig strand B	1024..1033	CDD:409353
		Ig strand C	1038..1047	CDD:409353
		Ig strand C'	1050..1052	CDD:409353
		Ig strand D	1058..1063	CDD:409353
		Ig strand F	1079..1086	CDD:409353
		Ig strand G	1089..1099	CDD:409353
		Ig	1105..1194	CDD:416386
		Ig strand A	1105..1108	CDD:409353
		Ig strand A'	1111..1116	CDD:409353
		Ig strand B	1121..1128	CDD:409353
		Ig strand C	1135..1141	CDD:409353
		Ig strand C'	1142..1145	CDD:409353
		Ig strand D	1150..1156	CDD:409353
		Ig strand E	1159..1169	CDD:409353
		Ig strand F	1173..1181	CDD:409353
		Ig strand G	1183..1194	CDD:409353
		I-set	1231..1320	CDD:400151
		Ig strand A	1231..1234	CDD:409353
		Ig strand A'	1237..1242	CDD:409353
		Ig strand B	1247..1254	CDD:409353
		Ig strand C	1261..1267	CDD:409353
		Ig strand C'	1268..1271	CDD:409353
		Ig strand D	1276..1282	CDD:409353
		Ig strand E	1285..1295	CDD:409353
		Ig strand F	1299..1307	CDD:409353
		Ig strand G	1309..1320	CDD:409353
		I-set	1527..1616	CDD:400151	6/17 (35%)
		Ig strand A'	1535..1538	CDD:409353
		Ig strand B	1542..1551	CDD:409353
		Ig strand C	1556..1562	CDD:409353
		Ig strand C'	1565..1567	CDD:409353
		Ig strand D	1573..1578	CDD:409353
		Ig strand E	1580..1588	CDD:409353
		Ig strand F	1596..1603	CDD:409353	2/4 (50%)
		Ig strand G	1606..1616	CDD:409353	1/9 (11%)
		PKc_like	1639..1894	CDD:419665	46/263 (17%)
		I-set	2923..3013	CDD:400151
		Ig strand A	2923..2926	CDD:409353
		Ig strand A'	2929..2934	CDD:409353
		Ig strand B	2939..2946	CDD:409353
		Ig strand C	2953..2959	CDD:409353
		Ig strand C'	2960..2963	CDD:409353
		Ig strand D	2969..2975	CDD:409353
		Ig strand E	2978..2988	CDD:409353
		Ig strand F	2992..3000	CDD:409353
		PHA03247	<3106..3499	CDD:223021
		PKc_like	3496..3752	CDD:419665
		I-set	50..132	CDD:400151
		Ig strand A	50..52	CDD:409353
		Ig strand A'	54..60	CDD:409353
		Ig strand B	67..74	CDD:409353
		Ig strand C	80..85	CDD:409353
		Ig strand C'	87..90	CDD:409353
Ig strand F	111..119	CDD:409353
Ig strand A	764..767	CDD:409353
I-set	765..854	CDD:400151
Ig strand A'	770..774	CDD:409353
Ig strand B	782..790	CDD:409353
Ig strand C	795..800	CDD:409353
Ig strand C'	803..805	CDD:409353
Ig strand D	811..816	CDD:409353
Ig strand E	819..824	CDD:409353
Ig strand F	833..841	CDD:409353
Ig strand G	844..854	CDD:409353
Ig	910..1000	CDD:416386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910