Protein Alignment CG14443 and DDX3X

DIOPT Version :10

• Sequence 1: NP_572330.2
• Gene: CG14443 / 31595
• FlyBaseID: FBgn0029880
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_001347.3
• Gene: DDX3X / 1654
• HGNCID: 2745
• Length: 662
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 167/646 - (25%)
• Similarity: 278/646 - (43%)
• Gaps: 112/646 - (17%)

  Fly   132 SGSESSSSDSNSGSSSDSDSTTGSSSHGSDTGERPRMRSAVFRIHET----WQSPNSFKAVKTSR 192
            :|.:.:|||:.||.|        ::|.|.......|.|.|....::.    |.|.....|..:..
Human    17 AGLDLNSSDNQSGGS--------TASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFG 73

  Fly   193 ENKESRSRSSSLPQKRFCPSKTQNDLTYGSPEPKSPSNRGRNSW-RVGMRTPWKKSQSRSMSCSS 256
            ...:||.:||....:             ||.......:|||:.: .:|.|      ..||
Human    74 SRSDSRGKSSFFSDR-------------GSGSRGRFDDRGRSDYDGIGSR------GDRS----- 114

  Fly   257 IQKILVSRSFTRSRSPHRNTLCYQDQSKNPSRPSNYNTWKQPM-------DEVY---NNAANYRK 311
                    .|.:......:..|.:         |:.:.|.:|:       .|::   |...|:.|
Human   115 --------GFGKFERGGNSRWCDK---------SDEDDWSKPLPPSERLEQELFSGGNTGINFEK 162

  Fly   312 RHNITLTSWNMRNLPEPVLSFERSGFNATILQQLEDQGYDGPTPIQAQTWSIAKEGKNIVMISGK 376
            ..:|.:.:.. .|.|..:.||........|:..:|...|..|||:|.....|.||.::::..:..
Human   163 YDDIPVEATG-NNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQT 226

  Fly   377 GTGKTLGYLLPGI--------------MKMHNQRGLMQHKKGPIVLILVDCREAAVMVQREVLYY 427
            |:|||..:|||.:              ||.:.:.|  :.|:.||.|:|...||.||.:..|...:
Human   227 GSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYG--RRKQYPISLVLAPTRELAVQIYEEARKF 289

  Fly   428 TNPLELRTHCLLGNSQWQGHAE-----CDLLVASAGRLLQMIDNKKHVVELERCTYLVLDNIDRM 487
            :....:|...:.|.:.......     |.||||:.|||:.|::..|  :.|:.|.|||||..|||
Human   290 SYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGK--IGLDFCKYLVLDEADRM 352

  Fly   488 IDVGLEGNICRLLCR--LRP----HAQLIVSSTSWSSNLKRMANKFLGQYTAIRVGEINNIGVRL 546
            :|:|.|..|.|::.:  :.|    |..:.  |.::...::.:|..||.:|..:.||   .:|...
Human   353 LDMGFEPQIRRIVEQDTMPPKGVRHTMMF--SATFPKEIQMLARDFLDEYIFLAVG---RVGSTS 412

  Fly   547 QNIRQRVEVVNGLSKVERLMKELTAIYDTSDIPGK---VVIYVKRQKVVEELVD-LIRNCVPCEG 607
            :||.|:|..|....|...|:..|.|       .||   .:::|:.:|..:.|.| |......|..
Human   413 ENITQKVVWVEESDKRSFLLDLLNA-------TGKDSLTLVFVETKKGADSLEDFLYHEGYACTS 470

  Fly   608 IHGGRTAQENQGIIHDFGTGAYNIIVATQMTSNCLDVPGIRYVINYDFPDNIDKYVQRMSRTGCL 672
            |||.|:.::.:..:|.|.:|...|:|||.:.:..||:..:::|||:|.|.:|::||.|:.|||.:
Human   471 IHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRV 535

  Fly   673 SYNRNCEVISFFTMANYKLVTEVVDFLKICKQEIGPHLLQLAEEKMFGPRQRRRHRPQRYN 733
            . |... ..|||...|..:..:::|.|...|||:...|..:|.|..:....|.|.:..|::
Human   536 G-NLGL-ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFS 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14443	NP_572330.2	DEAD-like_helicase_N	<310..720	CDD:475120	128/438 (29%)
DDX3X	NP_001347.3	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000269|PubMed:18636090	2..139		32/170 (19%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:30131165, ECO:0000269|PubMed:31575075	12..21		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144		32/173 (18%)
		Interaction with EIF4E. /evidence=ECO:0000269|PubMed:17667941	38..44		0/5 (0%)
		Interaction with VACV protein K7. /evidence=ECO:0000269|PubMed:19913487	81..90		2/21 (10%)
		Involved in binding to RNA G-quadruplex. /evidence=ECO:0000269|PubMed:30256975	88..123		10/66 (15%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:18846110	100..662		145/542 (27%)
		Interaction with IKBKE	100..110		3/9 (33%)
		Interaction with CHUK. /evidence=ECO:0000269|PubMed:17667941	139..172		6/32 (19%)
		DEADc_DDX3	160..410	CDD:350809	72/259 (28%)
		Q motif	180..208		8/27 (30%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding and HIV-1 replication	250..259		2/8 (25%)
		DEAD box	347..350		1/2 (50%)
		Interaction with HCV core protein. /evidence=ECO:0000269|PubMed:10329544	409..662		59/195 (30%)
		SF2_C_DEAD	415..545	CDD:350174	43/138 (31%)
		Interaction with NXF1. /evidence=ECO:0000269|PubMed:18596238	536..661		16/61 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..634