DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pat1 and Nphp3

DIOPT Version :9

Sequence 1:	NP_001259286.1	Gene:	Pat1 / 31593	FlyBaseID:	FBgn0029878	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_082997.3	Gene:	Nphp3 / 74025	MGIID:	1921275	Length:	1325	Species:	Mus musculus

Alignment Length:	589	Identity:	127/589 - (21%)
Similarity:	215/589 - (36%)	Gaps:	138/589 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 ENYVSRYEVVAGHEEEELESSMDTVEDRSTEFSSLYTYDSESTNADSISDFNDEFS-ADIGSIVG 177
            ::.||.|::|..|..|.:.|..|  ::..|:...|........:...:.:...|.| ..:.|||.
Mouse   738 QDTVSLYKLVLHHVRESMPSDRD--KEWMTQILCLINVSHNGVSESELMELYPEMSWLSLTSIVH 800

  Fly   178 LPHR-RATQEELDAINDSGLEELSAVELQVIDLGLRLGS--------FLSEAGWMQESITVLACL 233
            ..|: .........:....|:....|.||.::....:.|        |.|:..  |:.:|..:.
Mouse   801 SLHKMHLLTYSCGLLRFQHLQAWETVRLQYLEDPALVSSYREKLISYFASQLS--QDRVTWRSA- 862

  Fly   234 NVRLKDLPTHKHWL-------QFRLDCLQRLLYAESAHCNFKEAEKTYAELMGLNKWLNKSVPNQ 291
                .:||    ||       |....||..||.|::.   :|...  :|||  |:.|       |
Mouse   863 ----DELP----WLFQQQGSKQKLHSCLLNLLVAQNL---YKRGH--FAEL--LSYW-------Q 905

  Fly   292 LVAITYSQISAMYF-ARNEYKNSHLWSGLAMRFLKGYANPRTIIDVLRQAAKACVVKRDFARANL 355
            .|......::..|| :..:|:||           :|..|...:.|:.....:       |.:...
Mouse   906 FVGKDKGAMATEYFESLKQYENS-----------EGEENMLCLADLYETLGR-------FLKDLG 952

  Fly   356 LICQAV---RRAREY----FGPTHQKYGDALLDYGFFLLNVDSVFQSVNIYKEALAVRRGIFGNM 413
            |:.|||   :|:.|.    ..|.|.:...:|.......:.......:..:||:||.:....:|..
Mouse   953 LLSQAVVPLQRSLEIRETALDPDHPRVAQSLHQLAGVYVQWKKFGDAEQLYKQALEISENAYGAD 1017

  Fly   414 NFHVAIAHEDLSYAYYVHEYSTGDFSCAQDHVDKAVNIMQHLVPSNHLMLASAKRVKALLLEEIA 478
            :.|.|...|.|:..|:           .|:..::|    :|....:.::...|.|.|..|.....
Mouse  1018 HPHAARELEALATLYH-----------KQNKYEQA----EHFRKKSVIIRQQATRRKGSLYGFAL 1067

  Fly   479 LDKMADGIDEEDLLLQSEELHNFALLLSLQVFGEVNVQTAKHYGNLGRLYQTMNRFEEAERMHKK 543
            |.:.|         ||.|||          ..|:...:.|:....||.||...|..|.||:..|:
Mouse  1068 LRRRA---------LQLEEL----------TLGKDKPENARTLNELGVLYFLQNNLETAEQFLKR 1113

  Fly   544 AIKIKSELLGHFDYEVGLSIGHLASLYNYQMKKYRDAEQLYMRSIDISLRLFGNSYSGLEYDYLG 608
            :::::..:||....:...|:.:||:|.| :.|:|..||:||.|::||..|.....:..|.|....
Mouse  1114 SLEMRERVLGPDHPDCAQSLNNLAALCN-EKKQYEKAEELYERALDIRRRALAPDHPSLAYTVKH 1177

  Fly   609 LCHVYETLHNFEKYLKYAHKLENWQMLRGQNLTQNKSSYPAIEVDYSIEEVKAKYFSMCASKKSA 673
            |..:|:.....:|                        :.|..|:   ..|::.|.|.      ..
Mouse  1178 LAILYKKTGKVDK------------------------AVPLYEL---AVEIRQKSFG------PK 1209

  Fly   674 HPSV 677
            ||||
Mouse  1210 HPSV 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pat1	NP_001259286.1	DnaQ_like_exo	<53..110	CDD:299142
		TPR_12	478..547	CDD:290160	18/68 (26%)
		TPR_12	516..590	CDD:290160	24/73 (33%)
		TPR_10	517..553	CDD:290111	10/35 (29%)
		TPR repeat	518..546	CDD:276809	10/27 (37%)
		TPR repeat	559..590	CDD:276809	12/30 (40%)
		TPR repeat	603..628	CDD:276809	4/24 (17%)
Nphp3	NP_082997.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Kinesin-relat_1	76..145	CDD:289481
		Uso1_p115_C	113..199	CDD:282695
		OmpH	<120..>202	CDD:281871
		TPR 1	467..500
		P-loop_NTPase	502..>570	CDD:304359
		TPR 2	881..914		13/46 (28%)
		TPR 3	916..937		7/31 (23%)
		TPR_12	937..1012	CDD:290160	15/81 (19%)
		TPR_10	937..978	CDD:290111	10/47 (21%)
		TPR 4	938..971		8/39 (21%)
		TPR repeat	938..966	CDD:276809	7/34 (21%)
		TPR_12	976..1054	CDD:290160	15/92 (16%)
		TPR repeat	976..1009	CDD:276809	6/32 (19%)
		TPR_10	979..1020	CDD:290111	6/40 (15%)
		TPR 5	980..1013		5/32 (16%)
		TPR repeat	1022..1074	CDD:276809	13/75 (17%)
		TPR 6	1022..1055		7/47 (15%)
		TPR_12	1085..1162	CDD:290160	26/77 (34%)
		TPR_10	1088..1128	CDD:290111	12/39 (31%)
		TPR 7	1088..1121		10/32 (31%)
		TPR repeat	1088..1116	CDD:276809	10/27 (37%)
		TPR_12	1126..1204	CDD:290160	23/105 (22%)
		TPR_10	1130..1169	CDD:290111	15/39 (38%)
		TPR 8	1130..1163		14/33 (42%)
		TPR repeat	1130..1158	CDD:276809	12/28 (43%)
		TPR_12	1168..1246	CDD:290160	14/79 (18%)
		TPR repeat	1168..1201	CDD:276809	7/59 (12%)
		TPR 9	1172..1205		7/59 (12%)
		TPR_10	1177..1211	CDD:290111	8/66 (12%)
		TPR_12	1210..1288	CDD:290160	4/4 (100%)
		TPR_10	1213..1254	CDD:290111	1/1 (100%)
		TPR 10	1214..1247		127/589 (22%)
		TPR repeat	1214..1242	CDD:276809	127/589 (22%)
		TPR 11	1256..1289
		TPR repeat	1256..1284	CDD:276809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1293..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810