Protein Alignment CG3842 and Wwox

DIOPT Version :10

• Sequence 1: NP_572316.1
• Gene: CG3842 / 31576
• FlyBaseID: FBgn0029866
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_062519.2
• Gene: Wwox / 80707
• MGIID: 1931237
• Length: 414
• Species: Mus musculus
• Alignment Length: 295
• Identity: 120/295 - (40%)
• Similarity: 164/295 - (55%)
• Gaps: 20/295 - (6%)

  Fly    74 GKVVIVTGCNTGIGKETVLELAKRGARVYMACRDPGRCEAARLDIMDRSRNQQLFNRTLDLGSLQ 138
            ||||:|||.|:|||.||....|..||.|.:|||:..|...|...|::.....::...||||..|:
Mouse   124 GKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVSRILEEWHKAKVEAMTLDLAVLR 188

  Fly   139 SVRNFVERFKAEESRLDILINNAGVMACPRTLTADGFEQQFGVNHLGHFLLTNLLLDRLKHSSPS 203
            ||::|.|.|||:...|.:|:.|||..|.|..||.||.|..|.|||||||.|..||.|.|..|||:
Mouse   189 SVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSSPA 253

  Fly   204 RIVVVSSAAHLFGRINREDLMSEKNYSKF---------FGAYSQSKLANILFTLKLSTILKDTGV 259
            |::||||.:|.|..||  |...:.:.|:.         ..||::|||.||||:.:|...|...||
Mouse   254 RVIVVSSESHRFTDIN--DSSGKLDLSRLSPPRSDYWAMLAYNRSKLCNILFSNELHRRLSPRGV 316

  Fly   260 TVNCCHPG-VVRTEINRHFSGPGWMKTALQKGSLYFFKTPKAGAQTQLRLALDPQLEGSTGGYYS 323
            |.|..||| ::.:.|:|:    .|:...|...:..|.|:.:.||.|.:..|:.|:|||..|.|::
Mouse   317 TSNAVHPGNMMYSAIHRN----SWVYKLLFTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFN 377

  Fly   324 DCMRWPLFPWVRNMQTADWLWRESEKL----LGLP 354
            :|.|.......::.:||..||..||:|    ||.|
Mouse   378 NCCRCLPSEEAQSEETARALWELSERLIQDRLGSP 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3842	NP_572316.1	Rossmann-fold NAD(P)(+)-binding proteins	74..347	CDD:473865	114/282 (40%)
Wwox	NP_062519.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		WW	18..47	CDD:459800
		Nuclear localization signal	50..55
		WW	60..90	CDD:238122
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	117/288 (41%)
		Interaction with MAPT. /evidence=ECO:0000269|PubMed:15126504	125..414		119/294 (40%)
		Mediates targeting to the mitochondria	209..273		36/65 (55%)